The Journal of Thoracic and Cardiovascular Surgery
Volume 117, Issue 4 , Pages 751-758 , April 1999

Experimental and clinical evaluation of a new synthetic, absorbable sealant to reduce air leaks in thoracic operations

  • Paolo Macchiarini, MD, PhD

      Affiliations

    • Departments of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Marie-Lannelongue Hôpital, Paris-Sud University, Le Plessis Robinson, France
    • ,
  • John Wain, MD

      Affiliations

    • Thoracic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Mass
    • ,
  • Susan Almy, MS

      Affiliations

    • Statistics Unlimited, Inc, Westford, Mass.
    • ,
  • Philippe Dartevelle, MD

      Affiliations

    • Departments of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Marie-Lannelongue Hôpital, Paris-Sud University, Le Plessis Robinson, France

Received 24 July 1998 ,Revised 23 November 1998 ,Accepted 23 November 1998.

References 

  1. Kirsh MM, Rotman H, Behrendt DM, Orringer MB, Sloan H. Complications of pulmonary resection. Ann Thorac Surg. 1975;20:215–236
  2. Rice TW, Kirby TJ. Prolonged air leak. Chest Surg Clin North Am. 1992;2:803–811
  3. Keagy BA, Lores ME, Starek PJK, Murray GF, Lucas CL, Wilcox BR. Elective pulmonary lobectomy: factors associated with morbidity and operative mortality. Ann Thorac Surg. 1985;40:349–352
  4. Duque JL, Ramos G, Castrodeza J, et al.  Early complications in surgical treatment of lung cancer: a prospective, multicenter study. Ann Thorac Surg. 1997;63:944–950
  5. Cooper JD. Technique to reduce air leaks after resection of emphysematous lung. Ann Thorac Surg. 1994;57:1038–1039
  6. Alleyene CH, Cawley CM, Barrow DL, et al.  Efficacy and biocompatibility of a photopolymerized, synthetic, absorbable hydrogel as a dural sealant in a canine craniotomy model. J Neurosurg. 1998;2:308–313
  7. Ranger WR, Halpin D, Sawhney AS, Lyman M, LoCicero J. Pneumostasis of experimental air leaks with a new photopolymerized synthetic tissue sealant. Am Surg. 1997;63:788–795
  8. Woolson RF. Statistical methods for the analysis of biomedical data. New York: John Wiley & Sons; 1987;
  9. Lawless JE. Statistical models and methods for lifetime data. New York: John Wiley & Sons; 1982;
  10. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–748
  11. Sawhney AS, Lyman MD, Yao F, Lavine MA, Jarrett PK. A novel in situ formed hydrogel for use as a surgical sealant or barrier. Proceedings of the International Symposium on the Control of Relative Bioactivity Material. Controlled Release Society, Inc. 1996;23:236–237
  12. Wain J. Management of late postpneumonectomy empyema and bronchopleural fistula: empyema, spaces, and fistula. Chest Surg Clin N Am. 1996;6:529–541

☆ Address for reprints: Paolo Macchiarini, MD, PhD, Department of Thoracic and Vascular Surgery, Heidehaus Hospital (Hannover Medical School), 70, Leineufer, D-30419, Hannover, Germany.

☆☆ 12/1/96206

PII: S0022-5223(99)70296-5

The Journal of Thoracic and Cardiovascular Surgery
Volume 117, Issue 4 , Pages 751-758 , April 1999

Article Tools

* Image Usage & Resolution