The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 5 , Pages 1143-1152 , November 2010

Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium

Read at the 90th Annual Meeting of The American Association for Thoracic Surgery, Toronto, Ontario, Canada, May 1–5, 2010.

  • Michael P. Robich, MD, MSPH

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI
    • Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • ,
  • Louis M. Chu, MD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI
    • ,
  • Jun Feng, MD, PhD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI
    • ,
  • Thomas A. Burgess, MA

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI
    • ,
  • Roger J. Laham, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • ,
  • Cesario Bianchi, MD, PhD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI
    • ,
  • Frank W. Sellke, MD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI
    • Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • Department of Surgery, Division of Cardiothoracic Surgery, Rhode Island Hospital, Providence, RI
    • Corresponding Author InformationAddress for reprints: Frank W. Sellke, MD, Division of Cardiothoracic Surgery, Cardiovascular Research Center, Alpert Medical School, Brown University, 593 Eddy St, APC 424, Providence, RI 02903.

Received 22 April 2010 ,Revised 28 May 2010 ,Accepted 28 June 2010.

References 

  1. Coon KD, Inge LJ, Swetel K, Felton V, Stafford P, Bremner RM. Genomic characterization of the inflammatory response initiated by surgical intervention and the effect of perioperative cyclooxygenase 2 blockade. J Thorac Cardiovasc Surg. 2010;139:1253–12601260.e1-2
  2. Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med. 2000;343:1520–15282 p following 1528
  3. Farkouh ME, Greenberg BP. An evidence-based review of the cardiovascular risks of nonsteroidal anti-inflammatory drugs. Am J Cardiol. 2009;103:1227–1237
  4. Ott E, Nussmeier NA, Duke PC, Feneck RO, Alston RP, Snabes MC, et al. Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2003;125:1481–1492
  5. Cheng Y, Wang M, Yu Y, Lawson J, Funk CD, Fitzgerald GA. Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest. 2006;116:1391–1399
  6. Wu G, Luo J, Rana JS, Laham R, Sellke FW, Li J. Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Cardiovasc Res. 2006;69:512–519
  7. Meier P, Gloekler S, Zbinden R, Beckh S, de Marchi SF, Zbinden S, et al. Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements. Circulation. 2007;116:975–983
  8. Tofukuji M, Metais C, Li J, Franklin A, Simons M, Sellke FW. Myocardial VEGF expression after cardiopulmonary bypass and cardioplegia. Circulation. 1998;98(19 Suppl):II242–II248
  9. Boodhwani M, Mieno S, Feng J, Sodha NR, Clements RT, Xu SH, et al. Atorvastatin impairs the myocardial angiogenic response to chronic ischemia in normocholesterolemic swine. J Thorac Cardiovasc Surg. 2008;135:117–122
  10. Altman JD, Klassen CL, Bache RJ. Cyclooxygenase blockade limits blood flow to collateral-dependent myocardium during exercise. Cardiovasc Res. 1995;30:697–704
  11. Rossoni G, Muscara MN, Cirino G, Wallace JL. Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit. Br J Pharmacol. 2002;135:1540–1546
  12. Dai XZ, Bache RJ. Effect of indomethacin on coronary blood flow during graded treadmill exercise in the dog. Am J Physiol. 1984;247(3 Pt 2):H452–H458
  13. Sorensen DR, Read TA, Porwol T, Olsen BR, Timpl R, Sasaki T, et al. Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma. Neuro Oncol. 2002;4:1–8
  14. Johnson AG, Nguyen TV, Day RO. Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis. Ann Intern Med. 1994;121:289–300
  15. Zhang J, Ding EL, Song Y. Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. JAMA. 2006;296:1619–1632
  16. Funk CD, FitzGerald GA. COX-2 inhibitors and cardiovascular risk. J Cardiovasc Pharmacol. 2007;50:470–479
  17. Johnson AG, Nguyen TV, Owe-Young R, Williamson DJ, Day RO. Potential mechanisms by which nonsteroidal anti-inflammatory drugs elevate blood pressure: the role of endothelin-1. J Hum Hypertens. 1996;10:257–261
  18. Wu G, Mannam AP, Wu J, Kirbis S, Shie JL, Chen C, et al. Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF. Am J Physiol Heart Circ Physiol. 2003;285:H2420–H2429
  19. Lee JH, Koh H, Kim M, Park J, Lee SY, Lee S, et al. JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila. Cell Death Differ. 2006;13:1110–1122
  20. Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proc Natl Acad Sci U S A. 1996;93:12908–12913
  21. Ryan EP, Bushnell TP, Friedman AE, Rahman I, Phipps RP. Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. Cancer Immunol Immunother. 2008;57:347–358
  22. Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T, et al. Oxidative stress mediates tumor necrosis factor-α–induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation. 2003;107:1418–1423
  23. McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci U S A. 1999;96:272–277
  24. Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, et al. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med. 2005;352:1071–1080
  25. Solomon SD, Wittes J, Finn PV, Fowler R, Viner J, Bertagnolli MM, et al. Cardiovascular risk of celecoxib in 6 randomized placebo-controlled trials: the cross trial safety analysis. Circulation. 2008;117:2104–2113

 Supported by the National Heart, Lung and Blood Institute (F.S.W.) grants RO1HL46716, RO1HL69024, and RO1HL85647; by the National Institutes of Health (M.P.R.) grant 5T32-HL0074; and by the Irving Bard Memorial Fellowship (M.P.R., L.M.C.).

 Disclosures: F.W.S. has research support from Ikaria (Clinton, NJ) and Orthologic (Tempe, Ariz) and is a consultant for Novo Nordisk (Princeton, NJ) and Cubist Pharmaceuticals (Lexington, Mass). F.W.S. is a consultant for the law firms representing Pfizer (Princeton, NJ) in the Bextra/Celebrex litigation, but no funding was received for this study, and there was no consultation or notification regarding this study.

PII: S0022-5223(10)00765-8

doi: 10.1016/j.jtcvs.2010.06.057

The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 5 , Pages 1143-1152 , November 2010

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