The Journal of Thoracic and Cardiovascular Surgery
Volume 141, Issue 4 , Pages 995-1001 , April 2011

One single dose of histidine–tryptophan–ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: A prospective randomized study

  • Bjørn Braathen, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Oslo, Norway
    • ,
  • Anders Jeppsson, MD, PhD

      Affiliations

    • Department of Cardiovascular Surgery and Anesthesia, Sahlgrenska University Hospital, Gothenburg, Sweden
    • Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Henrik Scherstén, MD, PhD

      Affiliations

    • Department of Cardiovascular Surgery and Anesthesia, Sahlgrenska University Hospital, Gothenburg, Sweden
    • Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Ole M. Hagen, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Oslo, Norway
    • ,
  • Øystein Vengen, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Oslo, Norway
    • ,
  • Helena Rexius, MD, PhD

      Affiliations

    • Department of Cardiovascular Surgery and Anesthesia, Sahlgrenska University Hospital, Gothenburg, Sweden
    • Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Vincenzo Lepore, MD, PhD

      Affiliations

    • Department of Cardiovascular Surgery and Anesthesia, Sahlgrenska University Hospital, Gothenburg, Sweden
    • Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Theis Tønnessen, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, Oslo, Norway
    • University of Oslo, Faculty of Hospital Medicine and Center for Heart Failure Research, Oslo, Norway
    • Corresponding Author InformationAddress for reprints: Theis Tønnessen, MD, PhD, Department of Cardiothoracic Surgery, Oslo University Hospital Ullevål, and University of Oslo, Faculty of Hospital Medicine, Oslo, Norway.

Received 18 March 2010 ,Revised 31 May 2010 ,Accepted 5 July 2010.

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 The study was supported by The Ingegerd and Viking Olov Björk Scholarship received by Professor Theis Tønnessen and by Sahlgrenska University Hospital (ALF/LUA grant). Custodiol for this study was a generous gift from NordMedica ApS, Bredgade 41, Copenhagen, Denmark.

 ClinicalTrial.Gov. Protocol ID 2007-001780-30.

 Disclosures: Authors have nothing to disclose with regard to commercial support.

PII: S0022-5223(10)00731-2

doi: 10.1016/j.jtcvs.2010.07.011

The Journal of Thoracic and Cardiovascular Surgery
Volume 141, Issue 4 , Pages 995-1001 , April 2011

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