The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 2 , Pages 459-463 , August 2010

CLOVES syndrome with thoracic and central phlebectasia: Increased risk of pulmonary embolism

  • Ahmad I. Alomari, MD

      Affiliations

    • Division of Vascular and Interventional Radiology, Children's Hospital Boston and Harvard Medical School, Boston, Mass
    • Corresponding Author InformationAddress for reprints: Ahmad I. Alomari, MD, Division of Vascular and Interventional Radiology, Children's Hospital Boston and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115.
    • ,
  • Patricia E. Burrows, MD

      Affiliations

    • Division of Vascular and Interventional Radiology, Texas Children's Hospital, Houston, Tex
    • ,
  • Edward Y. Lee, MD, MPH

      Affiliations

    • Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, Mass
    • ,
  • Daniel J. Hedequist, MD

      Affiliations

    • Department of Orthopedic Surgery, Children's Hospital Boston and Harvard Medical School, Boston, Mass
    • ,
  • John B. Mulliken, MD

      Affiliations

    • Department of Plastic Surgery, Children's Hospital Boston and Harvard Medical School, Boston, Mass
    • ,
  • Steven J. Fishman, MD

      Affiliations

    • Department of Surgery, Children's Hospital Boston and Harvard Medical School, Boston, Mass

Received 20 October 2009 ,Revised 7 April 2010 ,Accepted 25 April 2010.

References 

  1. Sapp JC, Turner JT, van de Kamp JM, van Dijk FS, Lowry RB, Biesecker LG. Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. Am J Med Genet. 2007;143A:2944–2958
  2. Alomari AI. Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome. Clin Dysmorphol. 2009;18:1–7
  3. Huiras EE, Barnes CJ, Eichenfield LF, Pelech AN, Drolet BA. Pulmonary thromboembolism associated with Klippel-Trenaunay syndrome. Pediatrics. 2005;116:e596–e600
  4. Baskerville PA, Ackroyd JS, Lea Thomas M, Browse NL. The Klippel-Trenaunay syndrome: clinical, radiological and haemodynamic features and management. Br J Surg. 1985;72:232–236
  5. Cohen MM. Proteus syndrome: an update. Am J Med Genet C Semin Med Genet. 2005;137C:38–52
  6. Slavotinek AM, Vacha SJ, Peters KF, Biesecker LG. Sudden death caused by pulmonary thromboembolism in Proteus syndrome. Clin Genet. 2000;5:386–389
  7. Biesecker L. The challenges of Proteus syndrome: diagnosis and management. Eur J Hum Genet. 2006;14:1151–1157
  8. Siani A, Flaishman I, Schioppa A, Zaccaria A, Baldassarre E. Jugular venous phlebectasia: uncommon in children, anecdotal in adults. Am J Surg. 2008;195:419–420
  9. Makariou E, Pikis A, Harley EH. Cystic hygroma of the neck: association with a growing venous aneurysm. AJNR Am J Neuroradiol. 2003;24:2102–2104
  10. Joseph AE, Donaldson JS, Reynolds M. Neck and thorax venous aneurysm: association with cystic hygroma. Radiology. 1989;170:109–112
  11. Gürelik M, Ozüm U, Erdoğan H, Aslan A. Orbital lymphangioma and its association with intracranial venous angioma. Br J Neurosurg. 2004;18:168–170
  12. Tada H, Takanashi J, Barkovich AJ, Kohno Y. Intracranial dural venous anomalies in familial cervical cystic hygroma. Pediatr Neurol. 2005;32:50–52
  13. Linnemann B, Meister F, Schwonberg J, Schindewolf M, Zgouras D, Lindhoff-Last E. Hereditary and acquired thrombophilia in patients with upper extremity deep-vein thrombosis. Results from the MAISTHRO registry. Thromb Haemost. 2008;100:440–446
  14. Lee AY, Ginsberg JS. Venous thrombosis of the upper extremities. Curr Treat Options Cardiovasc Med. 2001;3:207–214
  15. Usoh F, Hingorani A, Ascher E, Shiferson A, Tran V, Mark N, et al. Long-term follow-up for superior vena cava filter placement. Ann Vasc Surg. 2008;23:350–354
  16. Yoon PJ, Messner AH. Lymphatic malformation with internal jugular phlebectasia. Otolaryngol Head Neck Surg. 2001;124:579–580

 Disclosures: None.

PII: S0022-5223(10)00427-7

doi: 10.1016/j.jtcvs.2010.04.023

The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 2 , Pages 459-463 , August 2010

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