The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 2 , Pages 464-470 , August 2010

Acute kidney injury after coronary artery bypass grafting: Does rhabdomyolysis play a role?

  • Umberto Benedetto, MD

      Affiliations

    • Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S. Andrea, Rome, Italy
    • Corresponding Author InformationAddress for reprints: Umberto Benedetto, MD, Cardiac Surgery Department, II School of Medicine, University of Rome “La Sapienza,” Via di Grottarossa 1035, 00100, Rome, Italy.
    • ,
  • Emiliano Angeloni, MD

      Affiliations

    • Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S. Andrea, Rome, Italy
    • ,
  • Remo Luciani, MD

      Affiliations

    • Nephrology Unit, G. Rummo Hospital, Benevento, Italy
    • ,
  • Simone Refice, MD

      Affiliations

    • Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S. Andrea, Rome, Italy
    • ,
  • Manuel Stefanelli, MD

      Affiliations

    • Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S. Andrea, Rome, Italy
    • ,
  • Cosimo Comito, MD

      Affiliations

    • Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S. Andrea, Rome, Italy
    • ,
  • Antonino Roscitano, MD

      Affiliations

    • Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S. Andrea, Rome, Italy
    • ,
  • Riccardo Sinatra, MD

      Affiliations

    • Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S. Andrea, Rome, Italy

Received 3 December 2009 ,Revised 6 February 2010 ,Accepted 20 March 2010.

References 

  1. Rosner MH, Okusa MK. Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol. 2006;1:19–32
  2. Nigwekar SU, Kandula P, Hix JK, Thakar CV. Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized and observational studies. Am J Kidney Dis. 2009;54:413–423
  3. Huerta-Alardín AL, Varon J, Marik PE. Bench-to-bedside review: rhabdomyolysis—an overview for clinicians. Crit Care. 2005;9:158–169
  4. Hiratsuka Y, Ishii T, Takeuchi F, Okadome A, Taira H. The risk of elevated creatinine kinase and myoglobulinemia due to incised muscles in patients who underwent urological surgery. J Urol. 2003;170:119–121
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  7. Miller CC, Villa MA, Sutton J, Lau D, Keyhani K, Estrera AL, et al. Serum myoglobin and renal morbidity and mortality following thoracic and thoraco-abdominal aortic repair: does rhabdomyolysis play a role?. Eur J Endovasc Surg. 2009;37:388–394
  8. Alterman I, Sidi A, Azamfirei L, Copotoiu A, Tiberiu E. Rhabdomyolysis: another complication after prolonged surgery. J Clin Anesth. 2007;19:64–66
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  10. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Kidney disease outcome quality initiative. Am J Kidney Dis. 2002;39(suppl):S1–S246
  11. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, et al. Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11:R31
  12. Chowdhury UK, Malik V, Yadav R, Seth S, Ramakrishnan L, Kalaivani M, et al. Myocardial injury in coronary artery bypass grafting: on-pump versus off-pump comparison by measuring high-sensitivity C-reactive protein, cardiac troponin I, heart-type fatty acid-binding protein, creatinine kinase-MB and myoglobin release. J Thorac Cardiovasc Surg. 2008;135:1110–1119
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  14. Bostanjian D, Anthone GJ, Hamoui N, Crookes PF. Rhabdomyolysis of gluteal muscles leading to renal failure: a potentially fatal complication of surgery in the morbidly obese. Obes Surg. 2003;13:302–305
  15. Abassi ZA, Hoffman A, Better O. Acute renal failure complicating muscle crush injury. Semin Nephrol. 1998;18:558–565
  16. Chatzizisis YS, Misirli G, Hatzitolios AI, Giannoglou GD. The Syndrome of rhabdomyolysis: complications and treatment. Eur J Int Med. 2008;19:568–574
  17. Heyman SN, Rosen S, Fuchs S, Epstein FH, Brezis M. Myoglobinuric acute renal failure in rat: a role for medullary hypoperfusion, hypoxia and tubular obstruction. J Am Soc Neprhol. 1996;7:1066–1074
  18. Thadhani R, Pascual M, Bonventre JV. Acute renal failure. N Engl J Med. 1996;334:1448–1460
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 Disclosures: None.

PII: S0022-5223(10)00323-5

doi: 10.1016/j.jtcvs.2010.03.028

The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 2 , Pages 464-470 , August 2010

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