The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 2 , Pages 447-452 , August 2010

Effects on pre- and posttransplant pulmonary hemodynamics in patients with continuous-flow left ventricular assist devices

  • Ranjit John, MD

      Affiliations

    • Division of Cardiothoracic Surgery, University of Minnesota, Minneapolis, Minn
    • Corresponding Author InformationAddress for reprints: Ranjit John, MD, Division of Cardiothoracic Surgery, University of Minnesota, Minneapolis, MN 55455.
  • ,
  • Kenneth Liao, MD

      Affiliations

    • Division of Cardiothoracic Surgery, University of Minnesota, Minneapolis, Minn
  • ,
  • Forum Kamdar, MD

      Affiliations

    • Department of Surgery and Division of Cardiology, University of Minnesota, Minneapolis, Minn
  • ,
  • Peter Eckman, MD

      Affiliations

    • Department of Surgery and Division of Cardiology, University of Minnesota, Minneapolis, Minn
  • ,
  • Andrew Boyle, MD

      Affiliations

    • Department of Surgery and Division of Cardiology, University of Minnesota, Minneapolis, Minn
  • ,
  • Monica Colvin-Adams, MD

      Affiliations

    • Department of Surgery and Division of Cardiology, University of Minnesota, Minneapolis, Minn

Received 30 November 2009 ,Revised 8 February 2010 ,Accepted 9 March 2010.

References 

  1. Taylor DO, Edwards LB, Aurora P, Christie JD, Dobbels F, Kirk R, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult heart transplant report-2008. J Heart Lung Transplant. 2008;27:943–956
  2. Frazier OH, Rose EA, McCarthy P, Burton NA, Tector A, Levin H, et al. Improved mortality and rehabilitation of transplant candidates treated with a long-term implantable left ventricular assist system. Ann Surg. 1995;222:327–336
  3. Griffith BP, Kormos RL, Borovetz HS, Litwak K, Antaki JF, Poirier VL, et al. HeartMate II left ventricular assist system: from concept to first clinical use. Ann Thorac Surg. 2001;71:116–120
  4. John R, Kamdar F, Liao K, Colvin-Adams M, Boyle A, Joyce L. Improved survival and decreasing incidence of adverse events using the HeartMate II left ventricular assist device as a bridge-to-transplant. Ann Thorac Surg. 2008;86:1227–1235
  5. John R, Rajasinghe H, Chen JM, Weinberg AD, Sinha P, Itescu S, et al. Impact of current management practices on early and late death in more than 500 consecutive cardiac transplant recipients. Ann Surg. 2000;232:302–311
  6. Costard-Jackle A, Hill I, Schroeder JS, Fowler MB. The influence of preoperative patient characteristics on early and late survival following cardiac transplantation. Circulation. 1991;84:III329–III337
  7. Chen JM, Levin HR, Michler RE, Prusmack CJ, Rose EA, Aaronson KD. Reevaluating the significance of pulmonary hypertension before cardiac transplantation: determination of optimal thresholds and quantification of the effect of reversibility on perioperative mortality. J Thorac Cardiovas Surg. 1997;114:627–634
  8. Haft J, Armstrong W, Dyke DB, Aaronson KD, Koelling TM, Farrar DJ, et al. Hemodynamic and exercise performance with pulsatile and continuous-flow left ventricular assist devices. Circulation. 2007;116:I8–I15
  9. Klotz S, Deng MC, Stymann J, Roetker J, Wilhelm MJ, Hammel D, et al. Left ventricular pressure and volume unloading during pulsatile versus nonpulsatile left ventricular assist device support. Ann Thorac Surg. 2004;77:143–150
  10. Garcia S, Kamdar F, Boyle A, Colvin-Adams M, Liao K, Joyce L, et al. Effects of pulsatile- and continuous-flow left ventricular assist devices on left ventricular unloading. J Heart Lung Transplant. 2008;27:261–267
  11. Thohan V, Stetson SJ, Nagueh SF, Rivas-Gotz C, Koerner MM, Lafuente JA, et al. Cellular and hemodynamic responses of failing myocardium to continuous flow mechanical circulatory support using the DeBakey-Noon left ventricular assist device: a comparative analysis with pulsatile-type devices. J Heart Lung Transplant. 2005;24:566–575
  12. Barbone A, Holmes JW, Heerdt PM. Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure. A primary role of mechanical unloading underlying reverse remodeling. Circulation. 2001;104:670–675
  13. Pamboukian SV, Carere RG, Webb JG, Cook RC, D'yachkova Y, Abel JG, et al. The use of milrinone in pre-transplant assessment of patients with congestive heart failure and pulmonary hypertension. J Heart Lung Transplant. 1999;18:367–371
  14. Argenziano M, Choudhri AF, Moazami N, Rose EA, Smith CR, Levin HR, et al. Randomized, double-blind trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension. Ann Thorac Surg. 1998;65:340–345
  15. Butler J, Stankewicz MA, Wu J, Chomsky DB, Howser RL, Khadim G, et al. Pre-transplant reversible pulmonary hypertension predicts higher risk for mortality after cardiac transplantation. J Heart Lung Transplant. 2005;24:170–177
  16. Klotz S, Wenzelburger F, Stypmann J, Welp H, Drees G, Schmid C, et al. Reversible pulmonary hypertension in heart transplant candidates: to transplant or not to transplant. Ann Thorac Surg. 2006;82:1770–1773
  17. Miller LW, Pagani FD, Russell SD, John R, Boyle AJ, Aaronson KD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007;357:885–896
  18. Feller ED, Sorensen EN, Haddad M, Pierson RN, Johnson FL, Brown JM, et al. Clinical outcomes are similar in pulsatile and nonpulsatile left ventricular assist device recipients. Ann Thorac Surg. 2007;83:1082–1088
  19. Klotz S, Stypmann J, Welp H, Schmid C, Drees G, Rukosujew A, et al. Does continuous flow left ventricular assist device technology have a positive impact on outcome pretransplant and posttransplant?. Ann Thorac Surg. 2006;82:1774–1778
  20. Martin J, Siegenthaler MP, Friesewinkel O, Fader T, van de Loo A, Trummer G, et al. Implantable left ventricular assist device for treatment of pulmonary hypertension in candidates for orthotopic heart transplantation—a preliminary study. Eur J Cardiothorac Surg. 2004;25:971–977
  21. Etz CD, Welp HA, Tjan TD, Hoffmeier A, Weigang E, Scheld HH, et al. Medically refractory pulmonary hypertension: treatment with nonpulsatile left ventricular assist devices. Ann Thorac Surg. 2007;83:1697–1706
  22. Salzberg SP, Lachat ML, von Harbou K, Zund G, Turina MI. Normalization of high pulmonary vascular resistance with LVAD support in heart transplantation candidates. Eur J Cardiothorac Surg. 2005;27:222–225
  23. Zimpfer D, Zrunek P, Roethy W, Czerny M, Schima H, Huber L, et al. Left ventricular assist devices decrease fixed pulmonary hypertension in cardiac transplant candidates. J Thorac Cardiovasc Surg. 2007;133:689–695
  24. Lindelow B, Andersson B, Waagstein F, Bergh CH. High and low pulmonary vascular resistance in heart transplant candidates. A 5-year follow up after heart transplantation shows continuous reduction in resistance and no difference in complication rate. Eur Heart J. 1999;20:148–156
  25. Goland S, Czer LSC, Kass RM, De Robertis MA, Mirocha J, Coleman B, et al. Pre-existing pulmonary hypertension in patients with end-stage heart failure: Impact on clinical outcome and hemodynamic follow-up after orthotopic heart transplantation. J Heart Lung Transplant. 2007;26:312–318

 Disclosures: None.

PII: S0022-5223(10)00267-9

doi: 10.1016/j.jtcvs.2010.03.006

The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 2 , Pages 447-452 , August 2010