The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 1 , Pages 12-18.e2 , July 2010

Controlled reperfusion after ischemia may be the unifying recovery denominator

  • Gerald D. Buckberg, MD

      Affiliations

    • Corresponding Author InformationAddress for reprints: Gerald D. Buckberg, MD, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 62-258 CHS, Los Angeles, CA 90095.

References 

  1. Buckberg GD. Studies of controlled reperfusion after ischemia: I. When is the cardiac muscle damaged irreversibly?. J Thorac Cardiovasc Surg. 1986;92:483–487
  2. Allen BS, Buckberg GD, Fontan F, Kirsh MM, Popoff G, Beyersdorf F, et al. Superiority of controlled surgical reperfusion vs. PTCA in acute coronary occlusion. J Thorac Cardiovasc Surg. 1993;105:864–884
  3. Beyersdorf F, Allen BS, Buckberg GD, Acar C, Okamoto F, Sjostrand F, et al. Studies on prolonged acute regional ischemia: I. Evidence for preserved cellular viability after 6 hours of coronary occlusion. J Thorac Cardiovasc Surg. 1989;98:112–126
  4. Allen BS, Buckberg GD, Schwaiger M, Yeatman L, Tillisch J, Kawata N, et al. Studies of controlled reperfusion after ischemia: XVI. Early recovery of regional wall motion in patients following surgical revascularization after eight hours of acute coronary occlusion. J Thorac Cardiovasc Surg. 1986;92:636–648
  5. Beyersdorf F, Mitrev Z, Ihnken K, Schmiedt W, Sarai K, Eckel L, et al. Controlled limb reperfusion in patients having cardiac operations [see comments]. J Thorac Cardiovasc Surg. 1996;111:873–881
  6. Halldorsson AO, Kronon M, Allen BS, Rahman S, Wang T, Layland M, et al. Controlled reperfusion prevents pulmonary injury after 24 hours of lung preservation. Ann Thorac Surg. 1998;66:877–884
  7. Castella M, Buckberg GD, Tan Z, Ignarro LJ. Neurological preservation by Na-H exchange inhibition prior to 90 minutes of hypothermic circulatory arrest. Ann Thorac Surg. 2005;79:646–654
  8. Buckberg GD, ed. Studies of controlled reperfusion after ischemia. J Thorac Cardiovasc Surg. 1986;92:483-648.
  9. Buckberg GD, ed. Studies of hypoxemic/reoxygenation injury. J Thorac Cardiovasc Surg. 1995;110:1163-86.
  10. Follette D, Livesay J, Maloney JV, Buckberg GD. Citrate reperfusion of ischemic heart on cardiopulmonary bypass. Surg Forum. 1976;27:244–246
  11. Kronon MT, Allen BS, Hernan J, Halldorsson AO, Rahman S, Buckberg GD, et al. Superiority of magnesium cardioplegia in neonatal myocardial protection. Ann Thorac Surg. 1999;68:2285–2291
  12. Rosenkranz ER, Okamoto F, Buckberg GD, Robertson JM, Vinten-Johansen J, Bugyi HI. Safety of prolonged aortic clamping with blood cardioplegia. III. Aspartate enrichment of glutamate-blood cardioplegia in energy-depleted hearts after ischemic and reperfusion injury. J Thorac Cardiovasc Surg. 1986;91:428–435
  13. Allen BS, Castella M, Buckberg GD, Tan Z. Conditioned blood reperfusion markedly enhances neurologic recovery after prolonged cerebral ischemia. J Thorac Cardiovasc Surg. 2003;126:1851–1858
  14. Buckberg GD. Strategies and logic of cardioplegic delivery to prevent, avoid, and reverse ischemic and reperfusion damage. J Thorac Cardiovasc Surg. 1987;93:127–139
  15. Castella M, Buckberg GD, Saleh S, Tan Z, Ignarro LJ. A new role for cardioplegic buffering: should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts?. J Thorac Cardiovasc Surg. 2003;126:1442–1448
  16. Okamoto F, Allen BS, Buckberg GD, Bugyi HI, Leaf J. Studies of controlled reperfusion after ischemia. Reperfusate conditions: XIV. Importance of ensuring gentle vs sudden reperfusion during relief of coronary occlusion. J Thorac Cardiovasc Surg. 1986;92:613–620
  17. Buckberg GD, Brazier JR, Nelson RL, Goldstein SM, McConnell DH, Cooper N. Studies of the effects of hypothermia on regional myocardial blood flow and metabolism during cardiopulmonary bypass. I. The adequately perfused beating, fibrillating and arrested heart. J Thorac Cardiovasc Surg. 1977;78:87–94
  18. Buckberg GD, Beyersdorf F, Allen BS, Robertson JR. Integrated myocardial management, background and initial application. J Card Surg. 1995;10:68–69
  19. Follette DM, Fey K, Buckberg GD, Helly JJ, Steed DL, Foglia RP, et al. Reducing postischemic damage by temporary modification of reperfusate calcium, potassium, pH, and osmolarity. J Thorac Cardiovasc Surg. 1981;82:221–238
  20. Buckberg G, Athanasuleas C, Saleh S. Septal myocardial protection during cardiac surgery for prevention of right ventricular dysfunction. Anadolu Kardiyol Derg. 2008;8(Suppl 2):108–116
  21. Okamoto F, Allen BS, Buckberg GD, Schwaiger M, Leaf J, Bugyi H, et al. Studies of controlled reperfusion after ischemia: VIII. Regional blood cardioplegic reperfusion on total vented bypass without thoracotomy: a new concept. J Thorac Cardiovasc Surg. 1986;92/3:553–563
  22. Beyersdorf F, Kirsh MM, Buckberg GD, Allen BS. Warm glutamate/aspartate-enriched blood cardioplegic solution for perioperative sudden death. J Thorac Cardiovasc Surg. 1992;104:1141–1147
  23. Allen BS, Veluz JS, Buckberg GD, Aeberhard E, Ignarro LJ. Deep hypothermic circulatory arrest and global reperfusion injury: avoidance by making a pump prime reperfusate—a new concept. J Thorac Cardiovasc Surg. 2003;125:625–632
  24. Trummer G, Foerster K, Buckberg GD, Benk C, Heilmann C, Mader I, et al. Successful resuscitation after prolonged periods of cardiac arrest—a new field in cardiac surgery. J Thorac Cardiovasc Surg. 2010;139:1325–1332
  25. Beyersdorf F, Acar C, Buckberg GD, Partington MT, Okamoto F, Allen BS, et al. Studies on prolonged regional ischemia. IV. Aggressive surgical treatment for intractable ventricular fibrillation after acute myocardial infarction. J Thorac Cardiovasc Surg. 1989;98:557–566

PII: S0022-5223(10)00157-1

doi: 10.1016/j.jtcvs.2010.02.014

The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 1 , Pages 12-18.e2 , July 2010

Article Tools