The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 4 , Pages 830-834 , April 2010

The Cardiothoracic Surgery Network: Randomized clinical trials in the operating room

  • Timothy J. Gardner, MD

      Affiliations

    • The Center for Heart and Vascular Health, Christiana Care Health System, Newark, Del
    • Corresponding Author InformationAddress for reprints: Timothy J. Gardner, MD, Medical Director, The Center for Heart and Vascular Health, Christiana Care Health System, PO Box 6001, 4755 Ogletown-Stanton Rd, Newark, DE 19718.
    • ,
  • Patrick T. O'Gara, MD

      Affiliations

    • Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Mass

References 

  1. National Heart, Lung, and Blood Institute. Network for cardiothoracic surgical investigations in cardiovascular medicine (U01). Available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-06-005.html.
  2. Srivastava AR, Banerjee A, Jacob S, Dunning J. Should patients undergoing coronary artery bypass grafting with mild to moderate ischaemic mitral regurgitation also undergo mitral valve repair or replacement?. Interact Cardiovasc Thorac Surg. 2007;6:538–546
  3. Penicka M, Linkova H, Lang O, Fojt R, Kocka V, Vanderheyden M, et al. Predictors of improvement of unrepaired moderate ischemic mitral regurgitation in patients undergoing elective isolated coronary artery bypass graft surgery. Circulation. 2009;120:1474–1481
  4. Badiwala MV, Verma S, Rao V. Surgical management of ischemic mitral regurgitation. Circulation. 2009;120:1287–1293
  5. Mihaljevic T, Gillinov M, Sabik JF. Functional ischemic mitral regurgitation: myocardial viability as a predictor of postoperative outcome after isolated coronary artery bypass grafting. Circulation. 2009;120:1459–1461
  6. Fattouch K, Guccione F, Sampognaro R, Panzarella G, Corrado E, Navarra E, et al. POINT: Efficacy of adding mitral valve restrictive annuloplasty to coronary artery bypass grafting in patients with moderate ischemic mitral valve regurgitation: a randomized trial. J Thorac Cardiovasc Surg. 2009;138:278–285
  7. Trento A, Goland S, De Robertis MA, Czer LS. COUNTERPOINT: Efficacy of adding mitral valve restrictive annuloplasty to coronary artery bypass grafting in patients with moderate ischemic mitral valve regurgitation. J Thorac Cardiovasc Surg. 2009;138:286–288
  8. Schroder JN, Williams ML, Hata JA, Muhlbaier LH, Swaminathan M, Mathew JP, et al. Impact of mitral valve regurgitation evaluated by intraoperative transesophageal echocardiography on long-term outcomes after coronary artery bypass grafting. Circulation. 2005;112(Suppl):I293–I298
  9. Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease. Circulation. 2006;114:e84–231
  10. Zoghbi WA, Enrique-Sarano M, Foster E, Grayburn PA, Kraft CD, Levine RA, et al. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr. 2003;16:777–802
  11. Grigioni F, Enrique-Sarano M, Zehr KJ, Bailey KR, Tajik AJ. lschemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation. 2001;103:1759–1764
  12. Borger MA, Asim A, Murphy PM, Doenst T, David TE. Chronic ischemic mitral regurgitation: repair, replace or rethink?. Ann Thorac Surg. 2006;81:1153–1161
  13. Magne J, Girerd N, Sénéchal M, Mathieu P, Dagenais F, Dumesnil JG, et al. Mitral repair versus replacement for ischemic mitral regurgitation: comparison of short-term and long-term survival. Circulation. 2009;120:S104–S111
  14. http://www.nhlbi.nih.gov/recovery/funding/challenge-grants.htm.

 Dr Gardner is Chair, CTSN Steering Committee. Dr O'Gara is Co-Chair, CTSN Steering Committee.

 The Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine is funded by the National Heart, Lung and Blood Institute under contract U01-HL088942 with additional support from the Canadian Institutes of Health and from the National Institute of Neurological Disorders and Stroke.

PII: S0022-5223(10)00121-2

doi: 10.1016/j.jtcvs.2010.02.001

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 4 , Pages 830-834 , April 2010

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