The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 6 , Pages 1402-1408 , June 2010

Glutaraldehyde treatment of allograft tissue decreases allosensitization after the Norwood procedure

  • Bryce J. Laing, MD

      Affiliations

    • Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • David B. Ross, MD

      Affiliations

    • Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    • Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Steven R. Meyer, MD, PhD

      Affiliations

    • Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Patricia Campbell, MBChB

      Affiliations

    • Department of Laboratory Medicine, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Anne M. Halpin, MSc

      Affiliations

    • Department of Laboratory Medicine, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Lori J. West, MD, DPhil

      Affiliations

    • Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    • Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Ivan M. Rebeyka, MD

      Affiliations

    • Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    • Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    • Corresponding Author InformationAddress for reprints: Ivan M. Rebeyka, MD, 3H2.06 WCM Health Sciences Centre, Edmonton, AB T6G 2B7, Canada.

Received 8 September 2009 ,Revised 26 November 2009 ,Accepted 19 December 2009.

References 

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  2. Meyer SR, Campbell PM, Rutledge JM, Halpin AM, Hawkins LE, Lakey JR, et al. Use of an allograft patch in repair of hypoplastic left heart syndrome may complicate future transplantation. Eur J Cardiothorac Surg. 2005;27:554–560
  3. Hawkins JA, Breinholt JP, Lambert LM, Fuller TC, Profaizer T, McGough EC, et al. Class I and class II anti-HLA antibodies after implantation of cryopreserved allograft material in pediatric patients. J Thorac Cardiovasc Surg. 2000;119:324–330
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  9. United Network for Organ Sharing. CPRA calculator. Available at: http://www.unos.org/resources/. Accessed July 28, 2009.
  10. Kobashigawa JA, Sabad A, Drinkwater D, Cogert GA, Moriguchi JD, Kawata N, et al. Pretransplant panel reactive-antibody screens. Are they truly a marker for poor outcome after cardiac transplantation?. Circulation. 1996;94(9 Suppl):II294–II297
  11. Baskett RJ, Ross DB, Nanton MA, Murphy DA. Factors in the early failure of cryopreserved homograft pulmonary valves in children: preserved immunogenicity?. J Thorac Cardiovasc Surg. 1996;112:1170–1179
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  19. Meyer SR, Nagendran J, Desai LS, Rayat GR, Churchill TA, Anderson CC, et al. Decellularization reduces the immune response to aortic valve allografts in the rat. J Thorac Cardiovasc Surg. 2005;130:469–476
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  22. Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft heart valves: comparison with aortic valves from orthotopic heart transplants. J Thorac Cardiovasc Surg. 1998;115:118–127
  23. Weber PA, Jouan J, Matsunaga A, Pettenazzo E, Joudinaud T, Thiene G, et al. Evidence of mitigated calcification of the Mosaic versus Hancock Standard valve xenograft in the mitral position of young sheep. J Thorac Cardiovasc Surg. 2006;132:1137–1143
  24. Christenson JT, Vala D, Sierra J, Beghetti M, Kalangos A. Blood group incompatibility and accelerated homograft fibrocalcifications. J Thorac Cardiovasc Surg. 2004;127:242–250

 Funding: Stollery Children's Hospital Foundation; Dr West's research is supported in part through US National Institutes of Health (Grant HL79067), Canadian Institutes for Health Research, Heart and Stroke Foundation of Canada, and Alberta Heritage Foundation for Medical Research.

 Disclosures: None

PII: S0022-5223(09)01679-1

doi: 10.1016/j.jtcvs.2009.12.034

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 6 , Pages 1402-1408 , June 2010

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