The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 3 , Pages 653-659 , September 2010

Cellular phenotype transformation occurs during thoracic aortic aneurysm development

  • Jeffrey A. Jones, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC
    • Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC
    • Corresponding Author InformationAddress for reprints: Jeffrey A. Jones, PhD, Assistant Professor/Research Health Scientist, Medical University of South Carolina, Ralph H. Johnson VA Medical Center, Cardiothoracic Surgery Research, Strom Thurmond Research Building, 114 Doughty Street, Suite 625, PO Box 250778, Charleston, SC 29425.
    • ,
  • Juozas A. Zavadzkas, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC
    • ,
  • Eileen I. Chang, BS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC
    • ,
  • Nina Sheats, BS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC
    • ,
  • Christine Koval, BS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC
    • ,
  • Robert E. Stroud, MS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC
    • ,
  • Francis G. Spinale, MD, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC
    • Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC
    • ,
  • John S. Ikonomidis, MD, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC

Received 19 August 2009 ,Revised 25 November 2009 ,Accepted 14 December 2009.

References 

  1. Barbour JR, Spinale FG, Ikonomidis JS. Proteinase systems and thoracic aortic aneurysm progression. J Surg Res. 2007;139:292–307
  2. Dapunt OE, Galla JD, Sadeghi AM, Lansman SL, Mezrow CK, de Asla RA, et al. The natural history of thoracic aortic aneurysms. J Thorac Cardiovasc Surg. 1994;107:1323–1333
  3. Davies RR, Gallo A, Coady MA, Tellides G, Botta DM, Burke B, et al. Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms. Ann Thorac Surg. 2006;81:169–177
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  6. Jones JA, Barbour JR, Lowry AS, Bouges S, Beck C, McClister DM, et al. Spatiotemporal expression and localization of matrix metalloproteinase-9 in a murine model of thoracic aortic aneurysm. J Vasc Surg. 2006;44:1314–1321
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  15. Jones JA, Barbour JR, Stroud RE, Bouges S, Stephens SL, Spinale FG, et al. Altered transforming growth factor-beta signaling in a murine model of thoracic aortic aneurysm. J Vasc Res. 2008;45:457–468
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 This work was supported by the National Institutes of Health/National Health, Lung, and Blood Institute R01 HL075488 (to J.S.I.) and R01 HL81692 (to F.G.S.), and by the Department of Veterans Affairs through a Career Development Award to J.A.J. (BLRD-CDA-2) and a Merit Award to F.G.S.

 Disclosures: None.

PII: S0022-5223(09)01678-X

doi: 10.1016/j.jtcvs.2009.12.033

The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 3 , Pages 653-659 , September 2010

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