The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 6 , Pages 1369-1370 , June 2010

Back to the bench: The rejuvenation of stem cell therapy—the therapeutic potential of CD133+ progenitor cells

  • Jian Guo, MD, PhD
    • ,
  • Ren-Ke Li, MD, PhD
    • ,
  • Richard D. Weisel, MD

      Affiliations

    • Corresponding Author InformationAddress for reprints: Richard D. Weisel, MD, FRCSC, MaRS Centre, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, ON, Canada M5G 1L7.

Received 3 December 2009 ,Accepted 4 December 2009.

References 

  1. Zhang Y, Wong S, LaFleche J, Crowe S, Mesana T, Suuronon E, et al. In vitro functional comparison of therapeutically relevant human vasculogenic progenitor cells used for cardiac cell therapy. J Thorac Cardiovasc Surg. 2010 Feb 18;[Epub ahead of print]
  2. Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Holschermann H, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006;355:1210–1221
  3. Lipinski MJ, Biondi-Zoccai GG, Abbate A, Khianey R, Sheiban I, Bartunek J, et al. Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol. 2007;50:1761–1767
  4. Fazel S, Chen L, Weisel RD, Angoulvant D, Seneviratne C, Fazel A, et al. Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor. J Thorac Cardiovasc Surg. 2005;130:1310
  5. Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P, et al. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest. 2006;116:1865–1877
  6. Yousef M, Schannwell CM, Kostering M, Zeus T, Brehm M, Strauer BE. The BALANCE Study: clinical benefit and long-term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial infarction. J Am Coll Cardiol. 2009;53:2262–2269
  7. Reffelmann T, Konemann S, Kloner RA. Promise of blood- and bone marrow-derived stem cell transplantation for functional cardiac repair: putting it in perspective with existing therapy. J Am Coll Cardiol. 2009;53:305–308
  8. Stamm C, Kleine HD, Choi YH, Dunkelmann S, Lauffs JA, Lorenzen B, et al. Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies. J Thorac Cardiovasc Surg. 2007;133:717–725
  9. Fritzenwanger M, Lorenz F, Jung C, Fabris M, Thude H, Barz D, et al. Differential number of CD34+, CD133+ and CD34+/CD133+ cells in peripheral blood of patients with congestive heart failure. Eur J Med Res. 2009;14:113–117
  10. Mathieu M, Bartunek J, El OB, Touihri K, Hadad I, Thoma P, et al. Cell therapy with autologous bone marrow mononuclear stem cells is associated with superior cardiac recovery compared with use of nonmodified mesenchymal stem cells in a canine model of chronic myocardial infarction. J Thorac Cardiovasc Surg. 2009;138:646–653
  11. Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM, et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg. 2002;73:1919–1925
  12. Angoulvant D, Fazel S, Weisel RD, Lai TY, Fedak PW, Chen L, et al. Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice. J Thorac Cardiovasc Surg. 2009;137:471–480
  13. Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP, et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult mesenchymal stem cells (Prochymal) after acute myocardial infarction. J Am Coll Cardiol. 2009;54:2277–2286

 Funding sources: Canadian Institutes of Health Research (MOP14795 to R-K.L.) and Heart and Stroke Foundation of Ontario (T6604 to R-K.L.; T5809 to R.D.W.). R-K.L. is a Career Investigator of the Heart and Stroke Foundation of Canada and holds a Canada Research Chair in cardiac regeneration. R.D.W. is the Director of the Toronto General Research Institute.

PII: S0022-5223(09)01595-5

doi: 10.1016/j.jtcvs.2009.12.002

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 6 , Pages 1369-1370 , June 2010

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