The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 701-706 , March 2010

A multicenter randomized controlled trial to assess the feasibility of testing modified ultrafiltration as a blood conservation technology in cardiac surgery

  • Munir Boodhwani, MD, MMSc, FRCSC

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottowa, Ontario, Canada
    • ,
  • Andrew Hamilton, MD, FRCSC

      Affiliations

    • Division of Cardiac Surgery, Queen's University, Kingston, Kingston, Ontario, Canada
    • ,
  • Benoit de Varennes, MD, FRCSC

      Affiliations

    • Division of Cardiac Surgery, Royal Victoria Hospital, Montreal, Quebec, Canada
    • ,
  • Thierry Mesana, MD, PhD, FRCSC

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottowa, Ontario, Canada
    • ,
  • K. Williams

      Affiliations

    • Department of Epidemiology and Community Medicine, University of Ottawa, Ottowa, Ontario, Canada
    • ,
  • George A. Wells, PhD

      Affiliations

    • Department of Epidemiology and Community Medicine, University of Ottawa, Ottowa, Ontario, Canada
    • ,
  • H. Nathan, MD, FRCPC

      Affiliations

    • Division of Cardiac Anaesthesia, University of Ottawa Heart Institute, Ottowa, Ontario, Canada
    • ,
  • Jean Yves Dupuis, MD, FRCPC

      Affiliations

    • Division of Cardiac Anaesthesia, University of Ottawa Heart Institute, Ottowa, Ontario, Canada
    • ,
  • A. Babaev, MD

      Affiliations

    • Division of Perfusion, University of Ottawa Heart Institute, Ottowa, Ontario, Canada
    • ,
  • P. Wells, MD, MSc, FRCPC

      Affiliations

    • Department of Medicine, University of Ottawa, Ottowa, Ontario, Canada
    • ,
  • Fraser D. Rubens, MD, MSc, FRCSC

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottowa, Ontario, Canada
    • Corresponding Author InformationAddress for reprints: Fraser D. Rubens, MD, MSc, FRCSC, Professor of Surgery, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, Ontario K1Y 4W7, Canada.

Received 13 July 2009 ,Revised 10 November 2009 ,Accepted 23 November 2009.

References 

  1. Ootaki Y, Yamaguchi M, Oshima Y, Yoshimura N, Oka S. Effects of modified ultrafiltration on coagulation factors in pediatric cardiac surgery. Surg Today. 2002;32:203–206
  2. Friesen RH, Campbell DN, Clarke DR, Tornabene MA. Modified ultrafiltration attenuates dilutional coagulopathy in pediatric open heart operations. Ann Thorac Surg. 1997;64:1787–1789
  3. Leyh RG, Bartels C, Joubert-Hubner E, Bechtel JF, Sievers HH. Influence of modified ultrafiltration on coagulation, fibrinolysis and blood loss in adult cardiac surgery. Eur J Cardiothorac Surg. 2001;19:145–151
  4. Chew MS, Brix-Christensen V, Ravn HB, Brandslund I, Ditlevsen E, Pedersen J, et al. Effect of modified ultrafiltration on the inflammatory response in paediatric open-heart surgery: a prospective, randomized study. Perfusion. 2002;17:327–333
  5. Tassani P, Richter JA, Eising GP, Barankay A, Braun SL, Haehnel CH, et al. Influence of combined zero-balanced and modified ultrafiltration on the systemic inflammatory response during coronary artery bypass grafting. J Cardiothorac Vasc Anesth. 1999;13:285–291
  6. Boodhwani M, Williams K, Babaev A, Gill G, Saleem N, Rubens FD. Ultrafiltration reduces blood transfusions following cardiac surgery: a meta-analysis. Eur J Cardiothorac Surg. 2006;30:892–897
  7. Luciani GB, Menon T, Vecchi B, Auriemma S, Mazzucco A. Modified ultrafiltration reduces morbidity after adult cardiac operations: a prospective, randomized clinical trial. Circulation. 2001;104(12 Suppl. 1):I253–I259
  8. Boldt J, Zickmann B, Fedderson B, Herold C, Dapper F, Hempelmann G. Six different hemofiltration devices for blood conservation in cardiac surgery. Ann Thorac Surg. 1991;51:747–753
  9. Bang H, Ni L, Davis CE. Assessment of blinding in clinical trials. Control Clin Trials. 2004;25:143–156
  10. Shevde K, Pagala M, Kashikar A, Tyagaraj C, Shahbaz N, Iqbal M, et al. Gender is an essential determinant of blood transfusion in patients undergoing coronary artery bypass graft procedure. J Clin Anesth. 2000;12:109–116

 Disclosures: None.

 This study was funded by grant NA 5565 from the Heart and Stroke Foundation of Ontario.

PII: S0022-5223(09)01554-2

doi: 10.1016/j.jtcvs.2009.11.056

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 701-706 , March 2010

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