The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 1 , Pages 233-239.e4 , July 2010

Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone

  • Kay Sun, PhD

      Affiliations

    • Department of Surgery, University of California, San Francisco, Calif
    • Veterans Affairs Medical Center, San Francisco, Calif
    • ,
  • Zhihong Zhang, MS

      Affiliations

    • Department of Surgery, University of California, San Francisco, Calif
    • Veterans Affairs Medical Center, San Francisco, Calif
    • ,
  • Takamaro Suzuki, MD

      Affiliations

    • Department of Surgery, University of California, San Francisco, Calif
    • Veterans Affairs Medical Center, San Francisco, Calif
    • ,
  • Jonathan F. Wenk, PhD

      Affiliations

    • Department of Surgery, University of California, San Francisco, Calif
    • Veterans Affairs Medical Center, San Francisco, Calif
    • ,
  • Nielen Stander, PhD

      Affiliations

    • Livermore Software Technology Corporation, Livermore, Calif
    • ,
  • Daniel R. Einstein, PhD

      Affiliations

    • Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Olympia, Wash
    • ,
  • David A. Saloner, PhD

      Affiliations

    • Department of Radiology, University of California, San Francisco, Calif
    • Veterans Affairs Medical Center, San Francisco, Calif
    • ,
  • Arthur W. Wallace, MD, PhD

      Affiliations

    • Department of Anesthesia, University of California, San Francisco, Calif
    • Veterans Affairs Medical Center, San Francisco, Calif
    • ,
  • Julius M. Guccione, PhD

      Affiliations

    • Department of Surgery, University of California, San Francisco, Calif
    • Department of Bioengineering, University of California, San Francisco, Calif
    • Veterans Affairs Medical Center, San Francisco, Calif
    • ,
  • Mark B. Ratcliffe, MD

      Affiliations

    • Department of Surgery, University of California, San Francisco, Calif
    • Department of Bioengineering, University of California, San Francisco, Calif
    • Veterans Affairs Medical Center, San Francisco, Calif
    • Corresponding Author InformationAddress for reprints: Mark Ratcliffe, MD, Surgical Service (112), San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121.

Received 7 June 2009 ,Revised 13 November 2009 ,Accepted 23 November 2009.

References 

  1. Dor V, Saab M, Coste P, Kornaszewska M, Montiglio F. Left ventricular aneurysm: a new surgical approach. Thorac Cardiovasc Surg. 1989;37:11–19
  2. Aguiar Ribeiro GC, Antoniali F, Lopes MM, Costa CE, Albuquerque AN, Franchini KG. Left ventricular reconstruction brings benefit for patients with ischemic cardiomyopathy. J Card Fail. 2006;12:189–194
  3. Dor V, Di Donato M, Sabatier M, Montiglio F, Civaia F. Left ventricular reconstruction by endoventricular circular patch plasty repair: a 17-year experience. Semin Thorac Cardiovasc Surg. 2001;13:435–447
  4. Jones RH, Velazquez EJ, Michler RE, Sopko G, Oh JK, O'Connor CM, et al. the STICH Hypothesis 2 Investigators. Coronary bypass surgery with or without surgical ventricular reconstruction. N Engl J Med. 2009;360:1705–1717
  5. Homans DC, Asinger R, Elsperger KJ, Erlien D, Sublett E, Mikell F, et al. Regional function and perfusion at the lateral border of ischemic myocardium. Circulation. 1985;71:1038–1047
  6. Guccione JM, Moonly SM, Moustakidis P, Costa KD, Moulton MJ, Ratcliffe MB, et al. Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study. Ann Thorac Surg. 2001;71:654–662
  7. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, et al. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005;289):H692–H700
  8. Jackson BM, Gorman JH, Moainie SL, Guy TS, Narula N, Narula J, et al. Extension of borderzone myocardium in postinfarction dilated cardiomyopathy. J Am Coll Cardiol. 2002;40:1160–1167discussion 1168–1171
  9. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, et al. Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep. J Thorac Cardiovasc Surg. 2005;130:1032–1038
  10. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, et al. Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. J Thorac Cardiovasc Surg. 2007;134:1017–1024
  11. Omens JH, May KD, McCulloch AD. Transmural distribution of three-dimensional strain in the isolated arrested canine left ventricle. Am J Physiol. 1991;261(3 Pt 2):H918–H928
  12. Moonly S. Experimental and computational analysis of left ventricular aneurysm mechanics. [dissertation] San Francisco (CA): Department of Bioengineering, University of California, San Francisco, with University of California, Berkeley; 2003;
  13. Guccione JM, McCulloch AD, Waldman LK. Passive material properties of intact ventricular myocardium determined from a cylindrical model. J Biomech Eng. 1991;113:42–55
  14. Guccione JM, Waldman LK, McCulloch AD. Mechanics of active contraction in cardiac muscle: part II—cylindrical models of the systolic left ventricle. J Biomech Eng. 1993;115:82–90
  15. Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, et al. Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study. Am J Physiol Heart Circ Physiol. 2005;288:H1844–H1850
  16. Guccione JM, Costa KD, McCulloch AD. Finite element stress analysis of left ventricular mechanics in the beating dog heart. J Biomech. 1995;28:1167–1177
  17. Lin DH, Yin FC. A multiaxial constitutive law for mammalian left ventricular myocardium in steady-state barium contracture or tetanus. J Biomech Eng. 1998;120:504–517
  18. Usyk TP, Mazhari R, McCulloch AD. Effect of laminar orthotropic myofiber architecture on regional stress and strain in the canine left ventricle. J Elasticity. 2000;61:143–164
  19. Stander N, Roux W, Eggleston T, Craig K. LS-OPT user's manual version 3.2. Livermore (CA): Livermore Software Technology Corporation; 2007;
  20. Declerck J, Denney TS, Ozturk C, O'Dell W, McVeigh ER. Left ventricular motion reconstruction from planar tagged MR images: a comparison. Phys Med Biol. 2000;45:1611–1632
  21. Denney TS, Gerber BL, Yan L. Unsupervised reconstruction of a three-dimensional left ventricular strain from parallel tagged cardiac images. Magn Reson Med. 2003;49:743–754
  22. Krueger C, Tian L. A comparison of the general linear mixed model and repeated measures ANOVA using a dataset with multiple missing data points. Biol Res Nurs. 2004;6:151–157
  23. Wooding W. Planning pharmaceutical clinical trials: Basic statistical principals. Probability and mathematical statistics. New York: John Wiley; 1994;pp 34-6
  24. Artrip JH, Oz MC, Burkhoff D. Left ventricular volume reduction surgery for heart failure: a physiologic perspective. J Thorac Cardiovasc Surg. 2001;122:775–782
  25. Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, et al. Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. Ann Thorac Surg. 2005;79:185–193
  26. Moulton MJ, Creswell LL, Actis RL, Myers KW, Vannier MW, Szabó BA, et al. An inverse approach to determining myocardial material properties. J Biomech. 1995;28:935–948
  27. Myers RH, Montgomery DC. Response surface methodology. New York: John Wiley; 1995;
  28. Stander N, Craig KJ. On the robustness of a simple domain reduction scheme for simulation based optimization. Eng Computations. 2002;19:431–450
  29. Guccione JM, McCulloch AD. Mechanics of active contraction in cardiac muscle: part I—constitutive relations for fiber stress that describe deactivation. J Biomech Eng. 1993;115:72–81
  30. Kentish JC, ter Keurs HE, Ricciardi L, Bucx JJ, Noble MI. Comparison between the sarcomere length-force relations of intact and skinned trabeculae from rat right ventricle. Influence of calcium concentrations on these relations. Circ Res. 1986;58:755–768
  31. Dispersyn G, Mesotten L, Meuris B, Maes A, Mortelmans L, Flameng W, et al. Dissociation of cardiomyocyte apoptosis and dedifferentiation in infarct border zones. Eur Heart J. 2002;23:849–857
  32. Narula N, Narula J, Zhang P, Haider N, Raghunath P, Britten R, et al. Is the myofibrillarlytic myocyte a forme fruste apoptotic myocyte?. Ann Thorac Surg. 2005;79:1333–1337
  33. Wilson EM, Moainie SL, Baskin JM, Lowry AS, Deschamps AM, Mukherjee R, et al. Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. Circulation. 2003;107:2857–2863
  34. Mukherjee R, Mingoia JT, Bruce JA, Austin JS, Stroud RE, Escobar GP, et al. Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006;291:H2216–H2228
  35. Sawicki G, Leon H, Sawicka J, Sariahmetoglu M, Schulze CJ, Scott PG, et al. Degradation of myosin light chain in isolated rat hearts subjected to ischemia–reperfusion injury: a new intracellular target for matrix metalloproteinase-2. Circulation. 2005;112:544–552
  36. Gao CQ, Sawicki G, Suarez-Pinzon WL, Csont T, Wozniak M, Ferdinandy P, et al. Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction. Cardiovasc Res. 2003;57:426–433
  37. Biagini E, Galema TW, Schinkel AF, Vletter WB, Roelandt JR, Ten Cate FJ. Myocardial wall thickness predicts recovery of contractile function after primary coronary intervention for acute myocardial infarction. J Am Coll Cardiol. 2004;43:1489–1493
  38. Cwajg JM, Cwajg E, Nagueh SF, He ZX, Qureshi U, Olmos LI, et al. End-diastolic wall thickness as a predictor of recovery of function in myocardial hibernation: relation to rest-redistribution T1-201 tomography and dobutamine stress echocardiography. J Am Coll Cardiol. 2000;35:1152–1161
  39. Nagueh SF, Mikati I, Weilbaecher D, Reardon MJ, Al-Zaghrini GJ, Cacela D, et al. Relation of the contractile reserve of hibernating myocardium to myocardial structure in humans. Circulation. 1999;100:490–496
  40. Moulton MJ, Downing SW, Creswell LL, Fishman DS, Amsterdam DM, Szabó BA, et al. Mechanical dysfunction in the border zone of an ovine model of left ventricular aneurysm. Ann Thorac Surg. 1995;60:986–997discussion 998
  41. Jackson BM, Gorman JH, Salgo IS, Moainie SL, Plappert T, St John-Sutton M, et al. Border zone geometry increases wall stress after myocardial infarction: contrast echocardiographic assessment. Am J Physiol Heart Circ Physiol. 2003;284:H475–H479
  42. Moustakidis P, Maniar HS, Cupps BP, Absi T, Zheng J, Guccione JM, et al. Altered left ventricular geometry changes the border zone temporal distribution of stress in an experimental model of left ventricular aneurysm: a finite element model study. Circulation. 2002;106(12 Suppl. 1):I168–I175
  43. Tozeren A. Continuum rheology of muscle contraction and its application to cardiac contractility. Biophys J. 1985;47:303–309

 This study was supported by National Institutes of Health grant R01-HL-77921 (to Dr Guccione), VA Merit Review (to Dr Wallace), and R01-HL-63348 (to Dr Ratcliffe).

 Disclosures: None.

PII: S0022-5223(09)01553-0

doi: 10.1016/j.jtcvs.2009.11.055

The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 1 , Pages 233-239.e4 , July 2010

Article Tools

* Image Usage & Resolution