The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 4 , Pages 801-806 , October 2010

Reduction in postsurgical adhesion formation after cardiac surgery by application of N,O-carboxymethyl chitosan

  • Juan Zhou, MD, PhD

      Affiliations

    • Department of Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    • Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    • ,
  • J. Michael Lee, PhD

      Affiliations

    • Department of Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    • School of Biomedical Engineering, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    • ,
  • Patricia Jiang, BSc

      Affiliations

    • Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    • ,
  • Susan Henderson, BSc

      Affiliations

    • Kytogenics Pharmaceuticals Ltd, Dartmouth, Nova Scotia, Canada
    • ,
  • Timothy D.G. Lee, PhD

      Affiliations

    • Department of Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    • Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    • Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    • Corresponding Author InformationAddress for reprints: Timothy D. G. Lee, PhD, Sir Charles Tupper Building, 5850 College Street, Dalhousie University, Halifax, NS, Canada, B3H 4H7.

Received 24 July 2009 ,Revised 17 October 2009 ,Accepted 14 November 2009.

References 

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  3. Tsukihara H, Takamoto S, Kitahori K, Matsuda K, Murakami A, Novick RJ, et al. Prevention of postoperative pericardial adhesions with a novel regenerative collagen sheet. Ann Thorac Surg. 2006;81:650–657
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  11. Clark RAF. 2nd ed. Wound Repair, Overview and General Considerations. The Molecular and Cellular Biology of Wound Repair. New York: Plenum Press; 1996;
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 This work was supported in full by Kytogenics Pharmaceuticals Ltd.

 Disclosures: S. Henderson is a shareholder in Kytogenics Pharmaceuticals Ltd. J. Zhou, M. Lee, P. Jiang, and T. Lee have no financial interest in Kytogenics Ltd.

PII: S0022-5223(09)01486-X

doi: 10.1016/j.jtcvs.2009.11.030

The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 4 , Pages 801-806 , October 2010

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