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The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 2
, Pages 305-312.e2
, August 2010
Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome
References
- . Marfan's syndrome. Lancet. 2005;366:1965–1976
- . Progression of aortic dilatation and the benefit of long-term β-adrenergic blockade in Marfan's syndrome. N Engl J Med. 1994;330:1335–1341
- . Effect of long-term β-blockade on aortic root compliance in patients with Marfan syndrome. Am Heart J. 1999;137:1057–1061
- . Arterial hemodynamic indexes in Marfan's syndrome. Circulation. 1989;79:854–862
- . Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in Marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9. Circ Res. 2008;102:e73–e85
- . Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome. Circ Res. 2007;101:512–522
- Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome. Br J Pharmacol. 2007;150:1075–1083
- Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science. 2006;312:117–121
- Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome. Nat Genet. 2003;33:407–411
- . Recent advances in understanding Marfan syndrome: should we now treat surgical patients with losartan?. J Thorac Cardiovasc Surg. 2008;135:389–394
- Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in Marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. 2003;108;(1 Suppl):II329-34
- Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Circulation. 2006;114(1 Suppl):I365–I370
- . Toward an understanding of dural ectasia: a light microscopy study in a murine model of Marfan syndrome. Spine. 2005;30:291–293
- . Transforming growth factor-β– and tumor necrosis factor-α–mediated induction and proteolytic activation of MMP-9 in human skin. J Biol Chem. 2001;276:22341–22350
- Matrix metalloproteinase 2 activation of transforming growth factor-β1 (TGF-β1) and TGF-β1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol. 2006;26:1503–1509
- Transforming growth factor-β1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events. Ann Thorac Surg. 2007;83:946–953
- A critical role for elastin signaling in vascular morphogenesis and disease. Development. 2003;130:411–423
- . Smooth muscle cell to elastic lamina connections in developing mouse aorta. Role in aortic medial organization. Lab Invest. 1993;68:89–99
- . Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1. J Biol Chem. 1996;271:4916–4922
- . Matrix metalloproteinase-specific inhibition of Ca2+ entry mechanisms of vascular contraction. J Vasc Surg. 2004;40:1001–1010
- . Transforming growth factor-β 1 impairs endothelin-1-mediated contraction of brain vessels by inducing mitogen-activated protein (MAP) kinase phosphatase-1 and inhibiting p38 MAP kinase. Mol Pharmacol. 2007;72:1476–1483
- Involvement of transforming growth factor-β in regulation of calcium transients in diabetic vascular smooth muscle cells. Am J Physiol Renal Physiol. 2003;285:F1258–F1270
- Smad2 mediates transforming growth factor-β induction of endothelial nitric oxide synthase expression. Circ Res. 2002;91:806–813
- The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis. Nat Med. 1995;1:74–79
- . Are the mechanisms for NO-dependent vascular remodeling different from vasorelaxation in vivo?. Arterioscler Thromb Vasc Biol. 2008;28:1207–1208
Supported by an operating grant from Canadian Institutes of Health Research. A.W.Y.C. is the recipient of Michael Smith Foundation for Health Research/St Paul Hospital's Foundation Trainee Award. H.H.C.Y. is the recipient of Michael Smith Foundation for Health Research Junior Trainee Award and NSERC: Alexander Graham Bell Canada Graduate Scholarship.
Disclosures: None.
PII: S0022-5223(09)01406-8
doi: 10.1016/j.jtcvs.2009.10.039
© 2010 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.
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The Journal of Thoracic and Cardiovascular Surgery
Volume 140, Issue 2
, Pages 305-312.e2
, August 2010
