The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 6 , Pages 1431-1435.e1 , June 2010

Type B thymoma: Is prognosis predicted only by World Health Organization classification?

  • Hong Kwan Kim, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • ,
  • Yong Soo Choi, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • ,
  • Jhingook Kim, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • ,
  • Young Mog Shim, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • ,
  • Joungho Han, MD, PhD

      Affiliations

    • Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • ,
  • Kwhanmien Kim, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • Corresponding Author InformationAddress for reprints: Kwhanmien Kim, MD, Professor, Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710, Korea.

Received 12 May 2009 ,Revised 10 September 2009 ,Accepted 8 October 2009.

References 

  1. Rosai J, Sobin LH. Histological typing of tumors of the thymus. World Health Organization International Histological Classification of Tumors. 2nd ed.. New York (NY): Springer-Verlag; 1999;
  2. Okumura M, Ohta M, Tateyama H, Nakagawa K, Matsumura A, Maeda H, et al. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma. A clinical study of 273 patients. Cancer. 2002;94:624–632
  3. Nakagawa K, Asamura H, Matsuno Y, Suzuki K, Kondo H, Maeshima A, et al. Thymoma: a clinicopathologic study based on the new World Health Organization classification. J Thorac Cardiovasc Surg. 2003;126:1134–1140
  4. Chen G, Marx A, Wen-Hu C, Yong J, Puppe B, Stroebel P, et al. New WHO histologic classification predicts prognosis of thymic epithelial tumors. A clinicopathologic study of 200 thymoma cases from China. Cancer. 2002;95:420–429
  5. Ströbel P, Bauer A, Puppe B, Kraushaar T, Krein A, Toyka K, et al. Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis. J Clin Oncol. 2004;22:1501–1509
  6. Kondo K, Yoshizawa K, Tsuyuguchi M, Kimura S, Sumitomo M, Morita J, et al. WHO histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg. 2004;77:1183–1188
  7. Kim DJ, Yang WI, Choi SS, Kim KD, Chung KY. Prognostic and clinical relevance of the World Health Organization schema for the classification of thymic epithelial tumors. A clinicopathologic study of 108 patients and literature review. Chest. 2005;127:755–761
  8. Masaoka A, Monden Y, Nakahara K, Tanioka T. Follow-up study of thymomas with special reference to their clinical stages. Cancer. 1981;48:2485–2492
  9. Chalabreysse L, Roy P, Cordier JF, Loire R, Gamondes JP, Thivolet-Bejui F. Correlation of the WHO schema for the classification of thymic epithelial neoplasms with prognosis: a retrospective study of 90 tumors. Am J Surg Pathol. 2002;26:1605–1611
  10. Rieker RJ, Hoegel J, Morresi-Hauf A, Hofmann WJ, Blaeker H, Penzel R, et al. Histologic classification of thymic epithelial tumors: comparison of established classification schemes. Int J Cancer. 2002;98:900–906
  11. Shimosato Y. Controversies surrounding the subclassification of thymoma. Cancer. 1994;74:542–544
  12. Dawson A, Ibrahim NB, Gibbs AR. Observer variation in the histopathological classification of thymoma: correlation with prognosis. J Clin Pathol. 1994;47:519–523
  13. Quintanilla-Martinez L, Wilkins EW, Choi N, Efird J, Hug E, Harris NL. Thymoma. Histologic subclassification is an independent prognostic factor. Cancer. 1994;74:606–617
  14. Suster S, Moran CA. Thymoma, atypical thymoma, and thymic carcinoma. A novel conceptual approach to the classification of thymic epithelial neoplasma. Am J Clin Pathol. 1999;111:826–833
  15. Ogawa K, Uno T, Toita T, Onishi H, Yoshida H, Kakinohana Y, et al. Postoperative radiotherapy for patients with completely resected thymoma. A multi-institutional, retrospective review of 103 patients. Cancer. 2002;94:1405–1413
  16. Schmidt-Wolf IG, Rockstroh JK, Schüller H, Hirner A, Grohe C, Müller-Hermelink HK, et al. Malignant thymoma: current status of classification and multimodality treatment. Ann Hematol. 2003;82:69–76
  17. Gripp S, Hilgers K, Wurm R, Schmitt G. Thymoma: prognostic factors and treatment outcomes. Cancer. 1998;83:1495–1503
  18. Eralp Y, Aydiner A, Kizir A, Kaytan E, Oral EN, Topuz E. Resectable thymoma: treatment outcome and prognostic factors in the late adolescent and adult age group. Cancer Invest. 2003;21:737–743
  19. Singhal S, Shrager JB, Rosenthal DI, LiVolsi VA, Kaiser LR. Comparison of stages I–II thymoma treated by complete resection with or without adjuvant radiation. Ann Thorac Surg. 2003;76:1635–1642
  20. Venuta F, Rendina EA, Longo F, Giacomo TD, Anile M, Mercadante E, et al. Long-term outcome after multimodality treatment for stage III thymic tumors. Ann Thorac Surg. 2003;76:1866–1872

 Disclosures: None.

PII: S0022-5223(09)01389-0

doi: 10.1016/j.jtcvs.2009.10.024

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 6 , Pages 1431-1435.e1 , June 2010