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The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 6
, Pages 1609-1617
, June 2010
Electron transport chain dysfunction in neonatal pressure-overload hypertrophy precedes cardiomyocyte apoptosis independent of oxidative stress
References
- . Cardiac hypertrophy: the good, the bad, and the ugly. Ann Rev Physiol. 2003;65:45–79
- Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium. J Thorac Cardiovasc Surg. 2009;137:1356–1362
- . Vascular endothelial growth factor prevents apoptosis and preserves contractile function in hypertrophied infant heart. Circulation. 2006;114(1 Suppl):I290–I295
- . Myocardial substrate metabolism in the normal and failing heart. Physiol Rev. 2005;85:1093–1129
- Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol. 2002;40:1267–1274
- Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol. 2006;168:1737–1748
- . Mitochondrial oxidative stress, DNA damage, and heart failure. Antioxid Redox Signaling. 2006;8:1737–1744
- . Role of mitochondria in human aging. J Biomed Sci. 1997;4:319–326
- . Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes. Antioxid Redox Signaling. 2006;8:2111–2124
- . Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. J Pharmacol Expl Ther. 2002;300:1101–1110
- . Apoptosis and oxidants in the heart. J Lab Clin Med. 2003;142:288–297
- . Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria. Am J Physiol Cell Physiol. 2008;294:C460–C466
- . Impaired insulin-signaling in hypertrophied hearts contributes to ischemic injury. Biochem Biophys Res Commun. 2005;331:15–22
- Noninvasive serial evaluation of myocardial mechanics in pressure overload hypertrophy of rabbit myocardium. Herz. 2003;28:52–62
- Promoting angiogenesis protects severely hypertrophied hearts from ischemic injury. Ann Thorac Surg. 2004;77:2004–2010discussion 2011
- . Opening of mitochondrial KATP channels enhances cardioprotection through the modulation of mitochondrial matrix volume, calcium accumulation, and respiration. Am J Physiol. 2004;287:H1967–H1976
- . An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria. Biochem Med Metab Biol. 1994;51:35–42
- In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, et al. editor. Short protocols in molecular biology. 5th ed. Hoboken: Wiley; 2002;
- Myocardial oxygenation at high workstates in hearts with left ventricular hypertrophy. Cardiovasc Res. 1999;42:616–626
- . Energy metabolism in heart failure and remodelling. Cardiovasc Res. 2009;81:412–419
- Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels. J Biol Chem. 2009;284:2045–2052
- . The nuclear encoded subunits of complex I from bovine heart mitochondria. Biochim Biophys Acta. 2003;1604:135–150
- . Inborn errors of complex II—unusual human mitochondrial diseases. Biochim Biophys Acta. 2002;1553:117–122
- . Cytochrome c oxidase biogenesis: new levels of regulation. IUBMB Life. 2008;60:557–568
- . HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell. 2007;129:111–122
- . Domestication of the cardiac mitochondrion for energy conversion. J Mol Cell Cardiol. 2009;46:832–841
- Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell. 2006;23:607–618
- . Activation of NADPH oxidase during progression of cardiac hypertrophy to failure. Hypertension. 2002;40:477–484
- . Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion. Cell Death Differ. 2008;15:686–690
- Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol. 2005;46:2116–2124
- Deferoxamine mediated activation of hypoxia inducible factor-1α (HIF-1α) upregulates target genes for protection of hypertrophied myocardium. Circulation. 2005;112(17):II-350
Supported by grants from National Heart, Lung and Blood Institute HL-075430 (to I. Friehs) and HL-063095 (to P. J. del Nido), and HL-074734 and HL-0066186 (to F. X. McGowan). Dr Griffiths was supported by the Harvard–Longwood Research Training in Vascular Surgery: T32 HL 007734 to F. W. Logerfo.
Disclosures: None.
PII: S0022-5223(09)01346-4
doi: 10.1016/j.jtcvs.2009.08.060
© 2010 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.
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The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 6
, Pages 1609-1617
, June 2010
