The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 765-773.e1 , March 2010

Should lung transplantation be performed for patients on mechanical respiratory support? The US experience

  • David P. Mason, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationAddress for reprints: David P. Mason, MD, Cleveland Clinic, Heart and Vascular Institute, Department of Thoracic and Cardiovascular Surgery, 9500 Euclid Avenue/Mail Stop J4-1, Cleveland, OH 44195.
    • ,
  • Lucy Thuita, MS

      Affiliations

    • Department of Quantitative Health Sciences, Research Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Edward R. Nowicki, MD, MS

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Sudish C. Murthy, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Gösta B. Pettersson, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Eugene H. Blackstone, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
    • Department of Quantitative Health Sciences, Research Institute, Cleveland Clinic, Cleveland, Ohio

Received 20 January 2009 ,Revised 10 July 2009 ,Accepted 17 September 2009.

References 

  1. International Guidelines for the Selection of Lung Transplant Candidates. The American Society for Transplant Physicians (ASTP)/American Thoracic Society(ATS)/European Respiratory Society(ERS)/International Society for Heart and Lung Transplantation(ISHLT). Am J Respir Crit Care Med. 1998;158:335–339
  2. Christie JD, Edwards LB, Aurora P, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult lung and heart/lung transplantation report—2008. J Heart Lung Transplant. 2008;27:957–969
  3. Egan TM, Murray S, Bustami RT, et al. Development of the new lung allocation system in the United States. Am J Transplant. 2006;6(5 Pt 2):1212–1227
  4. Davis SQ, Garrity ER. Organ allocation in lung transplant. Chest. 2007;132:1646–1651
  5. Massard G, Shennib H, Metras D, et al. Double-lung transplantation in mechanically ventilated patients with cystic fibrosis. Ann Thorac Surg. 1993;55:1087–1092
  6. Flume PA, Egan TM, Westerman JH, et al. Lung transplantation for mechanically ventilated patients. J Heart Lung Transplant. 1994;13(1 Pt 1):15–23
  7. Bartz RR, Love RB, Leverson GE, Will LR, Welter DL, Meyer KC. Pre-transplant mechanical ventilation and outcome in patients with cystic fibrosis. J Heart Lung Transplant. 2003;22:433–438
  8. Elizur A, Sweet SC, Huddleston CB, et al. Pre-transplant mechanical ventilation increases short-term morbidity and mortality in pediatric patients with cystic fibrosis. J Heart Lung Transplant. 2007;26:127–131
  9. Kotloff RM, Zuckerman JB. Lung transplantation for cystic fibrosis: special considerations. Chest. 1996;109:787–798
  10. Spahr JE, Love RB, Francois M, Radford K, Meyer KC. Lung transplantation for cystic fibrosis: current concepts and one center's experience. J Cyst Fibros. 2007;6:334–350
  11. Baz MA, Palmer SM, Staples ED, Greer DG, Tapson VF, Davis DD. Lung transplantation after long-term mechanical ventilation: results and 1-year follow-up. Chest. 2001;119:224–227
  12. Breiman L. Bagging predictors. Machine Learning. 1996;24:123–140
  13. Rubin DB. Multiple Imputation for Non-response in Surveys. New York: Wiley; 1997;
  14. Blackstone EH. Comparing apples and oranges. J Thorac Cardiovasc Surg. 2002;123:8–15
  15. Bergstralh EJ, Konsanke JL. Computerized Matching of Cases to Controls. Technical report No. 56. Department of Health Science Research. Rochester, MN: Mayo Clinic; 1995;
  16. Blackstone EH, Naftel DC, Turner ME. The decomposition of time-varying hazard into phases, each incorporating a separate stream of concomitant information. J Am Stat Assoc. 1986;81:615–624
  17. Veith FJ. Lung transplantation. Transplant Proc. 1977;9:203–208
  18. Smits JM, Mertens BJ, Van Houwelingen HC, Haverich A, Persijn GG, Laufer G. Predictors of lung transplant survival in eurotransplant. Am J Transplant. 2003;3:1400–1406
  19. Maurer JR, Frost AE, Estenne M, Higenbottam T, Glanville AR. International guidelines for the selection of lung transplant candidates. The International Society for Heart and Lung Transplantation, the American Thoracic Society, the American Society of Transplant Physicians, the European Respiratory Society. Transplantation. 1998;66:951–956
  20. Kadikar A, Maurer J, Kesten S. The six-minute walk test: a guide to assessment for lung transplantation. J Heart Lung Transplant. 1997;16:313–319
  21. O'Brien G, Criner GJ. Mechanical ventilation as a bridge to lung transplantation. J Heart Lung Transplant. 1999;18:255–265
  22. Low DE, Trulock EP, Kaiser LR, et al. Lung transplantation of ventilator-dependent patients. The Washington University Lung Transplantation Group. Chest. 1992;101:8–11
  23. Wells A, Faro A. Special considerations in pediatric lung transplantation. Semin Respir Crit Care Med. 2006;27:552–560
  24. Wust RC, Degens H. Factors contributing to muscle wasting and dysfunction in COPD patients. Int J Chron Obstruct Pulm dis. 2007;2:289–300
  25. Enright S, Chatham K, Ionescu AA, Unnithan VB, Shale DJ. The influence of body composition on respiratory muscle, lung function and diaphragm thickness in adults with cystic fibrosis. J Cyst Fibros. 2007;6:384–390
  26. Gruther W, Benesch T, Zorn C, et al. Muscle wasting in intensive care patients: ultrasound observation of the M. quadriceps femoris muscle layer. J Rehabil Med. 2008;40:185–189
  27. Vassilakopoulos T, Petrof BJ. Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med. 2004;169:336–341
  28. Schweickert WD, Hall J. ICU-acquired weakness. Chest. 2007;131:1541–1549
  29. Spicher JE, White DP. Outcome and function following prolonged mechanical ventilation. Arch Intern Med. 1987;147:421–425
  30. Pereszlenyi A, Lang G, Steltzer H, et al. Bilateral lung transplantation with intra- and postoperatively prolonged ECMO support in patients with pulmonary hypertension. Eur J Cardiothorac Surg. 2002;21:858–863
  31. Aigner C, Wisser W, Taghavi S, et al. Institutional experience with extracorporeal membrane oxygenation in lung transplantation. Eur J Cardiothorac Surg. 2007;31:468–474
  32. Jackson A, Cropper J, Pye R, Junius F, Malouf M, Glanville A. Use of extracorporeal membrane oxygenation as a bridge to primary lung transplant: 3 consecutive, successful cases and a review of the literature. J Heart Lung Transplant. 2008;27:348–352
  33. Fischer S, Hoeper MM, Bein T, et al. Interventional lung assist: a new concept of protective ventilation in bridge to lung transplantation. Asaio J. 2008;54:3–10
  34. Fischer S, Simon AR, Welte T, et al. Bridge to lung transplantation with the novel pumpless interventional lung assist device NovaLung. J Thorac Cardiovasc Surg. 2006;131:719–723
  35. Broome M, Palmer K, Schersten H, Frenckner B, Nilsson F. Prolonged extracorporeal membrane oxygenation and circulatory support as bridge to lung transplant. Ann Thorac Surg. 2008;86:1357–1360
  36. Fischer S, Hoeper MM, Tomaszek S, et al. Bridge to lung transplantation with the extracorporeal membrane ventilator Novalung in the veno-venous mode: the initial Hannover experience. Asaio J. 2007;53:168–170
  37. Christie JD. Lung allograft ischemic time: crossing the threshold. Am J Respir Crit Care Med. 2005;171:673–674
  38. Magee JC, Barr ML, Basadonna GP, et al. Repeat organ transplantation in the United States, 1996-2005. Am J Transplant. 2007;7(5 Pt 2):1424–1433
  39. Martinu T, Howell DN, Davis RD, Steele MP, Palmer SM. Pathologic correlates of bronchiolitis obliterans syndrome in pulmonary retransplant recipients. Chest. 2006;129:1016–1023
  40. Gonzalez-Castro A, Llorca J, Suberviola B, Diaz-Reganon G, Ordonez J, Minambres E. Influence of nutritional status in lung transplant recipients. Transplant Proc. 2006;38:2539–2540
  41. Madill J, Gutierrez C, Grossman J, et al. Nutritional assessment of the lung transplant patient: body mass index as a predictor of 90-day mortality following transplantation. J Heart Lung Transplant. 2001;20:288–296

 Disclosures: None.

 This study was supported in part by the Peter and Elizabeth C. Tower and Family Endowed Chair in Cardiothoracic Research, James and Sharon Kennedy, the Slosburg Family Charitable Trust, and Stephen and Saundra Spencer (to G.B.P.), and by the Kenneth Gee and Paula Shaw, PhD, Chair in Heart Research (to E.H.B.).

PII: S0022-5223(09)01258-6

doi: 10.1016/j.jtcvs.2009.09.031

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 765-773.e1 , March 2010

Article Tools

* Image Usage & Resolution