The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 5 , Pages 1286-1294.e2, May 2010

Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: Combined consequences for cell therapy in older recipients

  • Yufeng Zhuo, MD

      Affiliations

    • Division of Cardiovascular Surgery and Department of Surgery, Toronto General Research Institute and University of Toronto, Toronto, Ontario, Canada
    • Department of Cardiology, The Second Affiliated Hospital of Guangzhou Medical College, Guangzhou, China
    • ,
  • Shu-Hong Li, MD, MSc

      Affiliations

    • Division of Cardiovascular Surgery and Department of Surgery, Toronto General Research Institute and University of Toronto, Toronto, Ontario, Canada
    • ,
  • Min-Sheng Chen, MD

      Affiliations

    • Department of Cardiology, The Second Affiliated Hospital of Guangzhou Medical College, Guangzhou, China
    • ,
  • Jun Wu, MD

      Affiliations

    • Division of Cardiovascular Surgery and Department of Surgery, Toronto General Research Institute and University of Toronto, Toronto, Ontario, Canada
    • ,
  • Heather Y. McDonald Kinkaid, MSc

      Affiliations

    • Division of Cardiovascular Surgery and Department of Surgery, Toronto General Research Institute and University of Toronto, Toronto, Ontario, Canada
    • ,
  • Shafie Fazel, MD, PhD

      Affiliations

    • Division of Cardiovascular Surgery and Department of Surgery, Toronto General Research Institute and University of Toronto, Toronto, Ontario, Canada
    • ,
  • Richard D. Weisel, MD

      Affiliations

    • Division of Cardiovascular Surgery and Department of Surgery, Toronto General Research Institute and University of Toronto, Toronto, Ontario, Canada
    • R.D.W. and R.-K.L. contributed equally as co-corresponding authors of this manuscript.
    • ,
  • Ren-Ke Li, MD, PhD

      Affiliations

    • Division of Cardiovascular Surgery and Department of Surgery, Toronto General Research Institute and University of Toronto, Toronto, Ontario, Canada
    • R.D.W. and R.-K.L. contributed equally as co-corresponding authors of this manuscript.
    • Corresponding Author InformationAddress for reprints: Ren-Ke Li, MD, PhD, Department of Surgery, Division of Cardiovascular Surgery, Toronto General Research Institute, MaRS Centre, Toronto Medical Discovery Tower, Room 3-702, 101 College St, Toronto, ON, Canada M5G 1L7.

Received 18 June 2009; received in revised form 6 August 2009; accepted 26 August 2009. published online 20 November 2009.

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 Disclosures: Financial support was provided by grants to R.-K.L. from the Canadian Institutes of Health Research (MOP14795) and Eileen Mercier and ING Canada Inc and to R.W. from the Heart and Stroke Foundation of Ontario (T5809, T6148). R.-K.L. is a Career Investigator of the Heart and Stroke Foundation of Canada and holds a Canada Research Chair in cardiac regeneration.

 Dr Zhuo's current affiliation is Panyu He Xian Memorial Hospital, Guangzhou, China.

PII: S0022-5223(09)01171-4

doi:10.1016/j.jtcvs.2009.08.052

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 5 , Pages 1286-1294.e2, May 2010

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