The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 2 , Pages 483-488.e2 , February 2010

Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery

  • Kuang-Yu Liu, PhD

      Affiliations

    • Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • K.-Y.L. and J.D.M. contributed equally to this article.
  • ,
  • Jochen D. Muehlschlegel, MD

      Affiliations

    • Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • K.-Y.L. and J.D.M. contributed equally to this article.
    • Corresponding Author InformationAddress for reprints: Jochen D. Muehlschlegel, MD, Department of Anesthesiology, Perioperative and Pain Medicine, CWN L1, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.
  • ,
  • Tjörvi E. Perry, MD

      Affiliations

    • Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
  • ,
  • Amanda A. Fox, MD

      Affiliations

    • Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
  • ,
  • Charles D. Collard, MD

      Affiliations

    • Baylor College of Medicine, Division of Cardiovascular Anesthesia, The Texas Heart Institute, Saint Luke's Episcopal Hospital, Houston, Tex
  • ,
  • Simon C. Body, MBChB, MPH

      Affiliations

    • Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
  • ,
  • Stanton K. Shernan, MD

      Affiliations

    • Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass

Received 25 February 2009 ,Revised 20 May 2009 ,Accepted 20 June 2009.

References 

  1. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case–control study. Lancet. 2004;364:937–952
  2. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488–1491
  3. Consortium WTCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661–678
  4. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, et al. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007;357:443–453
  5. Larson MG, Atwood LD, Benjamin EJ, Cupples LA, RB D'Agostino, Fox CS, et al. Framingham Heart Study 100 K project: genome-wide associations for cardiovascular disease outcomes. BMC Med Genet. 2007;8(Suppl 1):S5
  6. Schunkert H, Gotz A, Braund P, McGinnis R, Tregouet DA, Mangino M, et al. Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation. 2008;117:1675–1684
  7. Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316:1491–1493
  8. Abdullah KG, Li L, Shen GQ, Hu Y, Yang Y, MacKinlay KG, et al. Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest). Ann Hum Genet. 2008;72(Pt 5):654–657
  9. Broadbent HM, Peden JF, Lorkowski S, Goel A, Ongen H, Green F, et al. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9 p. Hum Mol Genet. 2008;17:806–814
  10. Pasmant E, Laurendeau I, Heron D, Vidaud M, Vidaud D, Bieche I. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer Res. 2007;67:3963–3969
  11. Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell. 2006;127:265–275
  12. Devereaux PJ, Goldman L, Cook DJ, Gilbert K, Leslie K, Guyatt GH. Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk. CMAJ. 2005;173:627–634
  13. Podgoreanu MV, White WD, Morris RW, Mathew JP, Stafford-Smith M, Welsby IJ, et al. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation. 2006;114(1 Suppl):I275–I281
  14. Collard CD, Shernan SK, Fox AA, Bernig T, Chanock SJ, Vaughn WK, et al. The MBL2 “LYQA secretor” haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery. Circulation. 2007;116(11 Suppl):I106–I112
  15. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265
  16. Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316:1331–1336
  17. Kalinina N, Agrotis A, Antropova Y, Ilyinskaya O, Smirnov V, Tararak E, et al. Smad expression in human atherosclerotic lesions: evidence for impaired TGF-beta/Smad signaling in smooth muscle cells of fibrofatty lesions. Arterioscler Thromb Vasc Biol. 2004;24:1391–1396
  18. Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Mohlke KL, et al. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS ONE. 2009;4:e5027
  19. Raffetto JD, Leverkus M, Park HY, Menzoian JO. Synopsis on cellular senescence and apoptosis. J Vasc Surg. 2001;34:173–177
  20. Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J Am Coll Cardiol. 2008;52:378–384
  21. Thompson AR, Golledge J, Cooper JA, Hafez H, Norman PE, Humphries SE. Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion. Eur J Hum Genet. 2009;17:391–394Epub 2008 Oct 15
  22. Helgadottir A, Thorleifsson G, Magnusson KP, Gretarsdottir S, Steinthorsdottir V, Manolescu A, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet. 2008;40:217–224
  23. Samani NJ, Raitakari OT, Sipila K, Tobin MD, Schunkert H, Juonala M, et al. Coronary artery disease–associated locus on chromosome 9p21 and early markers of atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28:1679–1683
  24. Priebe HJ. Perioperative myocardial infarction—aetiology and prevention. Br J Anaesth. 2005;95:3–19
  25. Landesberg G, Luria MH, Cotev S, Eidelman LA, Anner H, Mosseri M, et al. Importance of long-duration postoperative ST-segment depression in cardiac morbidity after vascular surgery. Lancet. 1993;341:715–719
  26. Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, Hochman JS, et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina). J Am Coll Cardiol. 2000;36:970–1062
  27. Paynter NP, Chasman DI, Buring JE, Shiffman D, Cook NR, Ridker PM. Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med. 2009;150:65–72

 Disclosures: These studies were supported in part by the Bayer Fellowship in Blood Conservation, Biosite Inc. (San Diego, CA); NIH (HL-068774 and NCRR M01 02558) and a Society of Cardiovascular Anesthesiologists Research Starter Grant.

PII: S0022-5223(09)01090-3

doi: 10.1016/j.jtcvs.2009.06.032

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 2 , Pages 483-488.e2 , February 2010