The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 2 , Pages 474-482 , February 2010

Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia–reperfusion injury

  • Ashish K. Sharma, MBBS

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, Va
    • ,
  • Victor E. Laubach, PhD

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, Va
    • Corresponding Author InformationAddress for reprints: Victor E. Laubach, PhD, University of Virginia Health System Department of Surgery, PO Box 801359, Charlottesville, VA 22908.
    • ,
  • Susan I. Ramos

      Affiliations

    • Department of Medicine, University of Virginia Health System, Charlottesville, Va
    • ,
  • Yunge Zhao, MD, PhD

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, Va
    • ,
  • George Stukenborg, PhD

      Affiliations

    • Department of Public Health Sciences, University of Virginia Health System, Charlottesville, Va
    • ,
  • Joel Linden, PhD

      Affiliations

    • Department of Medicine, University of Virginia Health System, Charlottesville, Va
    • ,
  • Irving L. Kron, MD

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, Va
    • ,
  • Zequan Yang, MD, PhD

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, Va

Received 3 April 2009 ,Revised 15 June 2009 ,Accepted 9 August 2009.

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 Disclosures: Drs Linden and Kron were shareholders in Adenosine Therapeutics, LLC, the corporation that provided ATL313, during the time of this study.

 This study was funded by NIH/NHLBI grants RO1 HL077301 (to V.E.L.) and PO1 HL073361 (to J.L.).

PII: S0022-5223(09)01085-X

doi: 10.1016/j.jtcvs.2009.08.033

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 2 , Pages 474-482 , February 2010

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