The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 557-561 , March 2010

Larger aortic reconstruction corresponds to diminished left pulmonary artery size in patients with single-ventricle physiology

  • Lakshmi P. Dasi, PhD

      Affiliations

    • Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Ga
    • ,
  • Kartik S. Sundareswaran, PhD

      Affiliations

    • Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Ga
    • ,
  • Colleen Sherwin, BS

      Affiliations

    • Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Ga
    • ,
  • Diane de Zelicourt, MS

      Affiliations

    • Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Ga
    • ,
  • Kirk Kanter, MD

      Affiliations

    • Emory University, Atlanta, Ga
    • ,
  • Mark A. Fogel, MD

      Affiliations

    • Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pa
    • ,
  • Ajit P. Yoganathan, PhD

      Affiliations

    • Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Ga
    • Corresponding Author InformationAddress for reprints: Ajit P. Yoganathan, PhD, Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology and Emory University, Room 2119 U. A. Whitaker Building, 313 Ferst Dr, Atlanta, GA 30332-0535.

Received 21 February 2009 ,Revised 24 June 2009 ,Accepted 10 August 2009.

References 

  1. Disessa TG, Yeatman LA, Williams RG, Lois JF, Friedman WF, Laks H. Thrombosis complicating balloon angioplasty of left pulmonary artery stenosis after Fontan procedure—successful treatment with intravenous streptokinase. Am J Cardiol. 1985;55:610–611
  2. Lock JE, Castanedazuniga WR, Fuhrman BP, Bass JL. Balloon dilation angioplasty of hypoplastic and stenotic pulmonary arteries. Circulation. 1983;67:962–967
  3. Pekkan K, Kitajima HD, de Zelicourt D, Forbess JM, Parks WJ, Fogel MA, et al. Total cavopulmonary connection flow with functional left pulmonary artery stenosis—angioplasty and fenestration in vitro. Circulation. 2005;112:3264–3271
  4. Senzaki H, Masutani S, Kobayashi J, Kobayashi T, Sasaki N, Asano H, et al. Ventricular afterload and ventricular work in Fontan circulation—comparison with normal two-ventricle circulation and single-ventricle circulation with Blalock-Taussig shunts. Circulation. 2002;105:2885–2892
  5. Sundareswaran KS, Pekkan K, Dasi LP, Whitehead K, Sharma S, Kanter KR, et al. The total cavopulmonary connection resistance: a significant impact on single ventricle hemodynamics at rest and exercise. Am J Physiol Heart Circ Physiol. 2008;295:H2427–H2435
  6. Pekkan K, Dasi L, de Zélicourt D, Sundareswaran K, Fogel M, Kanter K, et al. Hemodynamic performance of stage-2 univentricular reconstruction: Glenn vs. hemi-Fontan templates. Ann Biomed Eng. 2009;37:50–63
  7. Whitehead KK, Pekkan K, Kitajima HD, Paridon SM, Yoganathan AP, Fogel MA. Nonlinear power loss during exercise in single-ventricle patients after the Fontan—insights from computational fluid dynamics. Circulation. 2007;116:I165–I171
  8. Dasi LP, KrishnankuttyRema R, Kitajima HD, Pekkan K, Sundareswaran K, Fogel M, et al. Fontan hemodynamics: importance of pulmonary artery diameter. J Thorac Cardiovasc Surg. 2009;137:560–564
  9. Senzaki H, Isoda T, Ishizawa A, Hishi T. Reconsideration of criteria for the Fontan operation—influence of pulmonary-artery size on postoperative hemodynamics of the Fontan operation. Circulation. 1994;89:266–271
  10. KrishnankuttyRema R, Dasi LP, Pekkan K, Sundareswaran K, Fogel M, Sharma S, et al. Quantitative analysis of extracardiac versus intraatrial Fontan anatomic geometries. Ann Thorac Surg. 2008;85:810–817
  11. Sundareswaran KS, Kanter KR, Kitajima HD, Krishnankutty R, Sabatier JF, Parks WJ, et al. Impaired power output and cardiac index with hypoplastic left heart syndrome: a magnetic resonance imaging study. Ann Thorac Surg. 2006;82:1267–1277
  12. Frakes DH, Conrad CP, Healy TM, Monaco JW, Fogel M, Sharma S, et al. Application of an adaptive control grid interpolation technique to morphological vascular reconstruction. IEEE Trans Biomed Eng. 2003;50:197–206
  13. Frakes DH, Smith MJT, Parks J, Sharma S, Fogel M, Yoganathan AP. New techniques for the reconstruction of complex vascular anatomies from MRI images. J Cardiovasc Magn Res. 2005;7:425–432
  14. Sluysmans T, Colan SD. Theoretical and empirical derivation of cardiovascular allometric relationships in children. J Appl Physiol. 2005;99:445–457

 Lakshmi P. Dasi's current affiliation is Department of Mechanical Engineering, Colorado State University, Fort Collins, Colo.

 Disclosures: None.

 We gratefully acknowledge the Bioengineering Research Partnership (BRP) grant from the National Institutes of Health (HL67622).

PII: S0022-5223(09)01077-0

doi: 10.1016/j.jtcvs.2009.08.023

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 557-561 , March 2010

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