Determination of the minimum number of lymph nodes to examine to maximize survival in patients with esophageal carcinoma: Data from the Surveillance Epidemiology and End Results database

Groth, Shawn S.; Virnig, Beth A.; Whitson, Bryan A.; DeFor, Todd E.; Li, Zhong-ze; Tuttle, Todd M.; Maddaus, Michael A.

doi:10.1016/j.jtcvs.2009.07.017

« Previous Next »The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 612-620, March 2010

Determination of the minimum number of lymph nodes to examine to maximize survival in patients with esophageal carcinoma: Data from the Surveillance Epidemiology and End Results database

Shawn S. Groth, MD
- University of Minnesota Department of Surgery, Division of Thoracic Foregut Surgery, Minneapolis, Minn
Beth A. Virnig, PhD
- University of Minnesota School of Public Health, Division of Health Policy and Management, Minneapolis, Minn
- University of Minnesota Cancer Center, Minneapolis, Minn
Bryan A. Whitson, MD
- University of Minnesota Department of Surgery, Division of Thoracic Foregut Surgery, Minneapolis, Minn
Todd E. DeFor, MS
- University of Minnesota Cancer Center, Minneapolis, Minn
Zhong-ze Li, MS
- University of Minnesota Cancer Center, Minneapolis, Minn
Todd M. Tuttle, MD
- University of Minnesota Department of Surgery, Division of Thoracic Foregut Surgery, Minneapolis, Minn
- University of Minnesota Cancer Center, Minneapolis, Minn
Michael A. Maddaus, MD
- University of Minnesota Department of Surgery, Division of Thoracic Foregut Surgery, Minneapolis, Minn
- University of Minnesota Cancer Center, Minneapolis, Minn
- Address for reprints: Michael A. Maddaus, MD, University of Minnesota Department of Surgery, Section of Thoracic and Foregut Surgery, MMC 207, 420 Delaware St SE, Minneapolis, MN 55455.

Received 12 November 2008; received in revised form 27 May 2009; accepted 6 July 2009. published online 26 August 2009.

Objective

We used a population-based cancer registry to examine the association between lymph node counts and mortality to determine the minimum number of lymph nodes that should be examined as part of esophageal resection.

Methods

Using the Surveillance Epidemiology and End Results database, we identified patients who had an esophagectomy for invasive esophageal carcinoma from 1988 through 2005 and who had a known number of lymph nodes examined pathologically. After stratifying patients (0, 1–11, 12–29, and 30 or more lymph nodes examined) based on a recursive partitioning analysis, we assessed the association between lymph nodes counts and mortality using the Kaplan-Meier method. To adjust for potential confounding covariates, we used a Cox proportional hazards regression model.

Results

Of the patients in the Surveillance Epidemiology and End Results database with esophageal cancer, 4882 met our inclusion criteria. We noted a significant difference between the lymph node groups with regards to unadjusted all-cause (P < .0001) and cancer-specific mortality (P = .004). After adjusting for cancer registry, patient factors, tumor characteristics, and timing of radiation therapy, we noted a significant difference between the lymph node groups with regards to all-cause and cancer-specific mortality. Compared with patients who had no lymph node evaluation, only patients who had more than 12 lymph nodes examined had a significant improvement in mortality; patients who had 30 or more lymph nodes examined had significantly lower mortality rates than the other groups.

Conclusion

To maximize all-cause and cancer-specific survival, esophageal cancer patients should have at least 30 lymph nodes examined pathologically as part of esophageal resection.

CTSNet classification: 7

Abbreviations and Acronyms: AJCC, American Joint Committee on Cancer, CI, confidence interval, GEJ, gastroesophageal junction, LN, lymph node, OR, odds ratio, SEER, Surveillance, Epidemiology, and End Results