The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 1 , Pages 209-216.e2 , January 2010

Impairment of human cell–based vasculogenesis in rats by hypercholesterolemia-induced endothelial dysfunction and rescue with l-arginine supplementation

  • Erik J. Suuronen, PhD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Samir Hazra, BSc

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Pingchuan Zhang, MD, PhD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Renaud Vincent, PhD

      Affiliations

    • Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    • ,
  • Premkumari Kumarathasan, PhD

      Affiliations

    • Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    • ,
  • Yan Zhang, MD, MSc

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Joel Price, MD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Vincent Chan, MD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Frank W. Sellke, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Boston, Mass
    • ,
  • Thierry G. Mesana, MD, PhD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • John P. Veinot, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Marc Ruel, MD, MPH

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • Corresponding Author InformationAddress for reprints: Marc Ruel, MD, MPH, University of Ottawa Heart Institute, Division of Cardiac Surgery, 40 Ruskin St, Laboratory H5227, Ottawa, Ontario, Canada, K1Y 4W7.

Received 23 July 2008 ,Revised 10 April 2009 ,Accepted 23 April 2009.

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 Supported by grant MOP-77536 from the Canadian Institutes of Health Research (to M.R. and E.J.S.) and by grant NA5905 from the Heart & Stroke Foundation of Canada (to M.R.).

PII: S0022-5223(09)00929-5

doi: 10.1016/j.jtcvs.2009.04.055

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 1 , Pages 209-216.e2 , January 2010

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