The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 1 , Pages 209-216.e2, January 2010

Impairment of human cell–based vasculogenesis in rats by hypercholesterolemia-induced endothelial dysfunction and rescue with l-arginine supplementation

  • Erik J. Suuronen, PhD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Samir Hazra, BSc

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Pingchuan Zhang, MD, PhD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Renaud Vincent, PhD

      Affiliations

    • Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    • ,
  • Premkumari Kumarathasan, PhD

      Affiliations

    • Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    • ,
  • Yan Zhang, MD, MSc

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Joel Price, MD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Vincent Chan, MD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Frank W. Sellke, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Boston, Mass
    • ,
  • Thierry G. Mesana, MD, PhD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • John P. Veinot, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Marc Ruel, MD, MPH

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • Corresponding Author InformationAddress for reprints: Marc Ruel, MD, MPH, University of Ottawa Heart Institute, Division of Cardiac Surgery, 40 Ruskin St, Laboratory H5227, Ottawa, Ontario, Canada, K1Y 4W7.

Received 23 July 2008; received in revised form 10 April 2009; accepted 23 April 2009.

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 Supported by grant MOP-77536 from the Canadian Institutes of Health Research (to M.R. and E.J.S.) and by grant NA5905 from the Heart & Stroke Foundation of Canada (to M.R.).

PII: S0022-5223(09)00929-5

doi:10.1016/j.jtcvs.2009.04.055

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 1 , Pages 209-216.e2, January 2010

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