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The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 4
, Pages 1008-1015.e1
, October 2009
Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated kinase 1/2
References
- . Aortic valve calcification: basic science to clinical practice. Heart. 2009;95:616–623
- . Calcific aortic stenosis: an update. Nat Clin Pract Cardiovasc Med. 2007;4:254–262
- Calcification and cellularity in human aortic heart valve tissue determine the differentiation of bone-marrow-derived cells. J Mol Cell Cardiol. 2006;41:642–649
- . Role of human valve interstitial cells in valve calcification and their response to atorvastatin. Circulation. 2006;114(suppl):I547–I552
- . Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician?. J Oral Sci. 2003;45:57–73
- . Molecular mechanisms of vascular calcification: lessons learned from the aorta. Arterioscler Thromb Vasc Biol. 2006;26:1423–1430
- Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. J Heart Valve Dis. 2004;13:560–566
- . Bone formation and inflammation in cardiac valves. Circulation. 2001;103:1522–1528
- . The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. Am J Pathol. 2007;171:1407–1418
- . Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. J Am Coll Cardiol. 2009;53:491–500
- Establishment and characterization of a stable cell line to evaluate cellular Runx2 activity. J Cell Biochem. 2004;91:1239–1247
- . Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein. Oncogene. 2002;21:7156–7163
- . Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity. J Biol Chem. 2004;279:37704–37715
- Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis. Am J Physiol Cell Physiol. 2008;294:C29–C35
- Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis. Atherosclerosis. 2003;170:205–211
- Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification. Int J Mol Med. 2005;16:869–872
- Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis. Ann Thorac Surg. 2008;86:71–76
- BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network. J Biol Chem. 2006;281:40515–40526
- . Bone morphogenetic proteins. Growth Factors. 2004;22:233–241
- . Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J Biol Chem. 2007;282:10405–10413
Supported in part by American Heart Association grant 0850148Z.
PII: S0022-5223(09)00878-2
doi: 10.1016/j.jtcvs.2009.06.024
© 2009 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.
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The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 4
, Pages 1008-1015.e1
, October 2009
