The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 4 , Pages 1033-1040 , April 2010

Altered coronary microvascular serotonin receptor expression after coronary artery bypass grafting with cardiopulmonary bypass

  • Michael P. Robich, MD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • ,
  • Eugenio G. Araujo, DVM, PhD

      Affiliations

    • School of Veterinary Medicine, Federal University of Goias, Goiania, Brazil
    • ,
  • Jun Feng, MD, PhD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • ,
  • Robert M. Osipov, MD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • ,
  • Richard T. Clements, PhD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • ,
  • Cesario Bianchi, MD, PhD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • ,
  • Frank W. Sellke, MD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass
    • Department of Surgery, Division of Cardiothoracic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI
    • Corresponding Author InformationAddress for reprints: Frank W. Sellke, MD, Beth Israel Deaconess Medical Center, 330 Brookline Ave. DANA 801, Boston, MA 02215.

Received 20 February 2009 ,Revised 16 May 2009 ,Accepted 31 May 2009.

References 

  1. Sellke FW, Li J, Stamler A, Lopez JJ, Thomas KA, Simons M. Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia. Surgery. 1996;120:182–188
  2. Luscher TF, Tanner FC, Tschudi MR, Noll G. Endothelial dysfunction in coronary artery disease. Annu Rev Med. 1993;44:395–418
  3. Perrault LP, Mahlberg F, Breugnot C, Bidouard JP, Villeneuve N, Vilaine JP, et al. Hypercholesterolemia increases coronary endothelial dysfunction, lipid content, and accelerated atherosclerosis after heart transplantation. Arterioscler Thromb Vasc Biol. 2000;20:728–736
  4. Buxton AE, Hirshfeld JW, Untereker WJ, Goldberg S, Harken AH, Stephenson LW, et al. Perioperative coronary arterial spasm: long-term follow-up. Am J Cardiol. 1982;50:444–451
  5. Skarvan K, Graedel E, Hasse J, Stulz P, Pfisterer M. Coronary artery spasms after coronary artery bypass surgery. Anesthesiology. 1984;61:323–327
  6. Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med. 1990;323:27–36
  7. Mohammad-Zadeh LF, Moses L, Gwaltney-Brant SM. Serotonin: a review. J Vet Pharmacol Ther. 2008;31:187–199
  8. Sun H, Mohri M, Shimokawa H, Usui M, Urakami L, Takeshita A. Coronary microvascular spasm causes myocardial ischemia in patients with vasospastic angina. J Am Coll Cardiol. 2002;39:847–851
  9. Stowe DF, Ebert TJ. Neural and endothelial control of the peripheral circulation—implications for anesthesia: part II, endothelium-mediated effects in the normal and diseased circulation. J Cardiothorac Vasc Anesth. 1996;10:159–171
  10. Sellke FW, Boyle EM, Verrier ED. Endothelial cell injury in cardiovascular surgery: the pathophysiology of vasomotor dysfunction. Ann Thorac Surg. 1996;62:1222–1228
  11. Sellke FW, Friedman M, Dai HB, Shafique T, Schoen FJ, Weintraub RM, et al. Mechanisms causing coronary microvascular dysfunction following crystalloid cardioplegia and reperfusion. Cardiovasc Res. 1993;27:1925–1932
  12. Metais C, Bianchi C, Li J, Simons M, Sellke FW. Serotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibition. Basic Res Cardiol. 2001;96:59–67
  13. Cote F, Fligny C, Fromes Y, Mallet J, Vodjdani G. Recent advances in understanding serotonin regulation of cardiovascular function. Trends Mol Med. 2004;10:232–238
  14. Ishida T, Hirata K, Sakoda T, Kawashima S, Akita H, Yokoyama M. Identification of mRNA for 5-HT1 and 5-HT2 receptor subtypes in human coronary arteries. Cardiovasc Res. 1999;41:267–274
  15. Chester AH, Martin GR, Bodelsson M, Arneklo-Nobin B, Tadjkarimi S, Tornebrandt K, et al. 5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries. Cardiovasc Res. 1990;24:932–937
  16. Shimizu M, Hata K, Takaoka H, Kanazawa K, Shinke T, Matsumoto H, et al. Sumatriptan provokes coronary artery spasm in patients with variant angina: possible involvement of serotonin 1B receptor. Int J Cardiol. 2007;114:188–194
  17. Dahlof CG, Mathew N. Cardiovascular safety of 5HT1B/1D agonists—is there a cause for concern?. Cephalalgia. 1998;18:539–545
  18. Metais C, Li J, Simons M, Sellke FW. Serotonin-induced coronary contraction increases after blood cardioplegia-reperfusion: role of COX-2 expression. Circulation. 1999;100(19 Suppl):II328–II334
  19. Berg KA, Clarke WP. Regulation of 5-HT(1A) and 5-HT(1B) receptor systems by phospholipid signaling cascades. Brain Res Bull. 2001;56:471–477
  20. Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, et al. The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury. Eur J Cardiothorac Surg. 2008;33:906–913
  21. Chilian WM, Layne SM, Klausner EC, Eastham CL, Marcus ML. Redistribution of coronary microvascular resistance produced by dipyridamole. Am J Physiol. 1989;256(2 Pt 2):H383–H390
  22. Lamping KG, Kanatsuka H, Eastham CL, Chilian WM, Marcus ML. Nonuniform vasomotor responses of the coronary microcirculation to serotonin and vasopressin. Circ Res. 1989;65:343–351
  23. Chilian WM, Layne SM, Eastham CL, Marcus ML. Heterogeneous microvascular coronary alpha-adrenergic vasoconstriction. Circ Res. 1989;64:376–388
  24. Ishida T, Kawashima S, Hirata K, Sakoda T, Shimokawa Y, Miwa Y, et al. Serotonin-induced hypercontraction through 5-hydroxytryptamine 1B receptors in atherosclerotic rabbit coronary arteries. Circulation. 2001;103:1289–1295
  25. Maddahi A, Edvinsson L. Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway. BMC Neurosci. 2008;9:85
  26. Rondelet B, Van Beneden R, Kerbaul F, Motte S, Fesler P, McEntee K, et al. Expression of the serotonin 1b receptor in experimental pulmonary hypertension. Eur Respir J. 2003;22:408–412
  27. Maseri A, L'Abbate A, Baroldi G, Chierchia S, Marzilli M, Ballestra AM, et al. Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of “preinfarction” angina. N Engl J Med. 1978;299:1271–1277
  28. Willerson JT, Golino P, Eidt J, Campbell WB, Buja LM. Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications. Circulation. 1989;80:198–205
  29. Villalón CM, Centurión D. Cardiovascular responses produced by 5-hydroxytriptamine: a pharmacological update on the receptors/mechanisms involved and therapeutic implications. Naunyn Schmiedebergs Arch Pharmacol. 2007;376:45–63
  30. Xu J, Jian B, Chu R, Lu Z, Li Q, Dunlop J, et al. Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells. Am J Pathol. 2002;161:2209–2218
  31. Hassantash SA, Omrani GR, Givtaj N, Afrakhteh M. Pharmacological prevention of the deleterious effects of cardiopulmonary bypass. Asian Cardiovasc Thorac Ann. 2007;15:218–224
  32. Heying R, van Oeveren W, Wilhelm S, Schumacher K, Grabitz RG, Messmer BJ, et al. Children undergoing cardiac surgery for complex cardiac defects show imbalance between pro- and anti-thrombotic activity. Crit Care. 2006;10:R165
  33. Huang H, Yao T, Wang W, Zhu D, Zhang W, Chen H, et al. Continuous ultrafiltration attenuates the pulmonary injury that follows open heart surgery with cardiopulmonary bypass. Ann Thorac Surg. 2003;76:136–140
  34. Shen RF, Tai HH. Thromboxanes: synthase and receptors. J Biomed Sci. 1998;5:153–172
  35. Miyata A, Yokoyama C, Ihara H, Bandoh S, Takeda O, Takahashi E, et al. Characterization of the human gene (TBXAS1) encoding thromboxane synthase. Eur J Biochem. 1994;224:273–279

 Disclosures: None.

PII: S0022-5223(09)00810-1

doi: 10.1016/j.jtcvs.2009.05.032

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 4 , Pages 1033-1040 , April 2010

Article Tools

* Image Usage & Resolution