The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 6 , Pages 1290-1296 , December 2009

Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet model of cardiopulmonary bypass

  • Taslim Allibhai, MD

      Affiliations

    • Department of Pediatrics, Wilford Hall USAF Medical Center, Lackland Air Force Base, San Antonio, Tex
    • Corresponding Author InformationAddress for reprints: Taslim F. Allibhai, MD, Wilford Hall Medical Center, 2200 Bergquist Dr, Suite 1, Lackland AFB, TX 78236-5300.
  • ,
  • Robert DiGeronimo, MD

      Affiliations

    • Department of Pediatrics, Wilford Hall USAF Medical Center, Lackland Air Force Base, San Antonio, Tex
  • ,
  • John Whitin, PhD

      Affiliations

    • Department of Pediatrics, Stanford University, Palo Alto, Calif
  • ,
  • Jorge Salazar, MD

      Affiliations

    • University of Texas Health Science Center, San Antonio, Tex
  • ,
  • Tom To-Sang Yu

      Affiliations

    • Department of Pediatrics, Stanford University, Palo Alto, Calif
  • ,
  • Xuefeng Bruce Ling, PhD

      Affiliations

    • Department of Pediatrics, Stanford University, Palo Alto, Calif
  • ,
  • Harvey Cohen, MD, PhD

      Affiliations

    • Department of Pediatrics, Stanford University, Palo Alto, Calif
  • ,
  • Patricia Dixon

      Affiliations

    • Department of Pediatrics, Wilford Hall USAF Medical Center, Lackland Air Force Base, San Antonio, Tex
  • ,
  • Ashima Madan, MD

      Affiliations

    • Department of Pediatrics, Stanford University, Palo Alto, Calif

Received 9 January 2009 ,Revised 8 April 2009 ,Accepted 8 June 2009.

References 

  1. Wernovsky G, Shillingford AJ, Gaynor JW. Central nervous system outcomes in children with complex congenital heart disease. Curr Opin Cardiol. 2005;20:94–99
  2. Hsia TY, Gruber PJ. Factors influencing neurologic outcome after neonatal cardiopulmonary bypass: what we can and cannot control. Ann Thorac Surg. 2006;81:S2381–S2388
  3. Scallan MJ. Cerebral injury during paediatric heart surgery: perfusion issues. Perfusion. 2004;19:221–228
  4. Amir G, Ramamoorthy C, Riemer RK, Reddy VM, Hanley FL. Neonatal brain protection and deep hypothermic circulatory arrest: pathophysiology of ischemic neuronal injury and protective strategies. Ann Thorac Surg. 2005;80:1955–1964
  5. Chock VY, Amir G, Davis CR, Ramamoorthy C, Riemer RK, Ray D, et al. Antegrade cerebral perfusion reduces apoptotic neuronal injury in a neonatal piglet model of cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2006;131:659–665
  6. Goldberg CS, Bove EL, Devaney EJ, Mollen E, Schwartz E, Tindall S, et al. A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: outcomes for infants with functional single ventricle. J Thorac Cardiovasc Surg. 2007;133:880–887
  7. Oppido G, Napoleone CP, Turci S, Davies B, Frascaroli G, Martin-Suarez S, et al. Moderately hypothermic cardiopulmonary bypass and low-flow antegrade selective cerebral perfusion for neonatal aortic arch surgery. Ann Thorac Surg. 2006;82:2233–2239
  8. Myung RJ, Petko M, Judkins AR, Schears G, Ittenbach RF, Waibel RJ, et al. Regional low-flow perfusion improves neurologic outcome compared with deep hypothermic circulatory arrest in neonatal piglets. J Thorac Cardiovasc Surg. 2004;127:1051–1056discussion 6-7
  9. Hagl C, Khaladj N, Peterss S, Hoeffler K, Winterhalter M, Karck M, et al. Hypothermic circulatory arrest with and without cold selective antegrade cerebral perfusion: impact on neurological recovery and tissue metabolism in an acute porcine model. Eur J Cardiothorac Surg. 2004;26:73–80
  10. Fraser C, Andropoulos D. Principles of antegrade cerebral perfusion during arch reconstruction in newborns/infants. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2008;11:61–68
  11. Khaladj N, Peterss S, Oetjen P, von Wasielewski R, Hauschild G, Karck M, et al. Hypothermic circulatory arrest with moderate, deep or profound hypothermic selective antegrade cerebral perfusion: which temperature provides best brain protection?. Eur J Cardiothorac Surg. 2006;30:492–498
  12. Kamiya H, Hagl C, Kropivnitskaya I, Weidemann J, Kallenbach K, Khaladj N, et al. Quick proximal arch replacement with moderate hypothermic circulatory arrest. Ann Thorac Surg. 2007;83:1055–1058
  13. Kamiya H, Hagl C, Kropivnitskaya I, Bothig D, Kallenbach K, Khaladj N, et al. The safety of moderate hypothermic lower body circulatory arrest with selective cerebral perfusion: a propensity score analysis. J Thorac Cardiovasc Surg. 2007;133:501–509
  14. Rubin RB, Merchant M. A rapid protein profiling system that speeds study of cancer and other diseases. Am Clin Lab. 2000;19:28–29
  15. Conrads TP, Fusaro VA, Ross S, Johann D, Rajapakse V, Hitt BA, et al. High-resolution serum proteomic features for ovarian cancer detection. Endocr Relat Cancer. 2004;11:163–178
  16. Madan A, El-Ferzli G, Carlson SM, Whitin JC, Schilling J, Najmi A, et al. A potential biomarker in the cord blood of preterm infants who develop retinopathy of prematurity. Pediatr Res. 2007;61:215–221
  17. Gravett MG, Novy MJ, Rosenfeld RG, Reddy AP, Jacob T, Turner M, et al. Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers. JAMA. 2004;292:462–469
  18. Lewczuk P, Esselmann H, Groemer TW, Bibl M, Maler JM, Steinacker P, et al. Amyloid beta peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease. Biol Psychiatry. 2004;55:524–530
  19. Davidsson P, Sjogren M. The use of proteomics in biomarker discovery in neurodegenerative diseases. Dis Markers. 2005;21:81–92
  20. Otto M, Lewczuk P, Wiltfang J. Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases. Methods. 2008;44:289–298
  21. Sheikh AM, Barrett C, Villamizar N, Alzate O, Miller S, Shelburne J, et al. Proteomics of cerebral injury in a neonatal model of cardiopulmonary bypass with deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg. 2006;132:820–828
  22. Tchervenkov CI, Korkola SJ, Shum-Tim D, Calaritis C, Laliberte E, Reyes TU, et al. Neonatal aortic arch reconstruction avoiding circulatory arrest and direct arch vessel cannulation. Ann Thorac Surg. 2001;72:1615–1620
  23. Benjamini Y, Hochberg Y. Controlling the false discovery rate—a practical and powerful approach to multiple testing. J R Statist Soc B. 1995;57:289–300
  24. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A. 2001;98:5116–5121
  25. Efron B, Tibshirani R. Empirical Bayes methods and false discovery rates for microarrays. Genet Epidemiol. 2002;23:70–86
  26. Aubert J, Bar-Hen A, Daudin JJ, Robin S. Determination of the differentially expressed genes in microarray experiments using local FDR. BMC Bioinformatics. 2004;5:125
  27. Carlson SM, Najmi A, Whitin JC, Cohen HJ. Improving feature detection and analysis of surface-enhanced laser desorption/ionization-time of flight mass spectra. Proteomics. 2005;5:2778–2788
  28. Gerszten R, Accurso F, Bernard G, Caprioli R, Klee E, Klee G, et al. Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Program. Am J Physiol Lung Cell Mol Physiol. 2008;295:L16–L22
  29. Baggerly KA, Morris JS, Coombes KR. Reproducibility of SELDI–TOF protein patterns in serum: comparing datasets from different experiments. Bioinformatics. 2004;20:777–785
  30. Gray R, MacGregor G, Noble D, Imrie M, Dewar M, Boyd C, et al. Sputum proteomics in inflammatory and suppurative respiratory diseases. Am J Respir Crit Care Med. 2008;178:444–452

 The views and opinions expressed in this manuscript are those of the authors and do not reflect the official policy or position of the Air Force Medical Department, Department of the Air Force, the Department of Defense, or the United States Government.

PII: S0022-5223(09)00797-1

doi: 10.1016/j.jtcvs.2009.06.001

The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 6 , Pages 1290-1296 , December 2009