The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 4 , Pages 959-964 , October 2009

Prophylactic nesiritide does not prevent dialysis or all-cause mortality in patients undergoing high-risk cardiac surgery

  • A. Ahsan Ejaz, MD

      Affiliations

    • Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Fla
    • Corresponding Author InformationAddress for reprints: A. Ahsan Ejaz, MD, Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610-0224.
    • ,
  • Tomas D. Martin, MD

      Affiliations

    • Division of Thoracic and Cardiothoracic Surgery, University of Florida, Gainesville, Fla
    • ,
  • Richard J. Johnson, MD

      Affiliations

    • Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Fla
    • Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colo
    • ,
  • Almut G. Winterstein, PhD

      Affiliations

    • Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, Fla
    • ,
  • Charles T. Klodell, MD

      Affiliations

    • Division of Thoracic and Cardiothoracic Surgery, University of Florida, Gainesville, Fla
    • ,
  • Philip J. Hess Jr., MD

      Affiliations

    • Division of Thoracic and Cardiothoracic Surgery, University of Florida, Gainesville, Fla
    • ,
  • Ayad K. Ali, PharmD

      Affiliations

    • Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, Fla
    • ,
  • Elaine M. Whidden, ARNP

      Affiliations

    • Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Fla
    • ,
  • Nancy L. Staples, RN

      Affiliations

    • Division of Thoracic and Cardiothoracic Surgery, University of Florida, Gainesville, Fla
    • ,
  • James A. Alexander, MD

      Affiliations

    • Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colo
    • ,
  • Mary Ann House-Fancher, ARNP

      Affiliations

    • Division of Thoracic and Cardiothoracic Surgery, University of Florida, Gainesville, Fla
    • ,
  • Thomas M. Beaver, MD, MPH

      Affiliations

    • Division of Thoracic and Cardiothoracic Surgery, University of Florida, Gainesville, Fla

Received 15 September 2008 ,Revised 16 February 2009 ,Accepted 15 May 2009.

References 

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  10. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, et al. Acute Kidney Injury Network. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11:R31
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  16. Bove T, Landoni G, Calabrò MG, Aletti G, Marino G, Cerchierini E, et al. Renoprotective action of fenoldopam in high-risk patients undergoing cardiac surgery: a prospective, double-blind, randomized clinical trial. Circulation. 2005;111:3230–3235
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  18. Lassnigg A, Donner E, Grubhofer G, Presterl E, Druml W, Hiesmayr M. Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. J Am Soc Nephrol. 2000;11:97–104
  19. Lanese DM, Yuan BH, Falk SA, Conger JD. Effects of atriopeptin III on isolated rat afferent and efferent arterioles. Am J Physiol. 1991;261:F1102–F1109
  20. Houben AJ, van der Zander K, de Leeuw PW. Vascular and renal actions of brain natriuretic peptide in man: physiology and pharmacology. Fundam Clin Pharmacol. 2005;19:411–419
  21. Swärd K, Valsson F, Odencrants P, Samuelsson O, Ricksten SE. Recombinant human atrial natriuretic peptide in ischemic acute renal failure: a randomized placebo-controlled trial. Crit Care Med. 2004;32:1310–1315
  22. Chen HH, Sundt TM, Cook DJ, Heublein DM. Burnett JC Jr. Low dose nesiritide and the preservation of renal function in patients with renal dysfunction undergoing cardiopulmonary-bypass surgery: a double-blind placebo-controlled pilot study. Circulation. 2007;116:I134–I138

 Disclosures: The study was conducted under an investigator-proposed research grant from Scios, Inc. The authors do not have any other conflict of interest.

 Clinical trials registration:ClinicalTrials.gov NCT00110201.

PII: S0022-5223(09)00712-0

doi: 10.1016/j.jtcvs.2009.05.014

The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 4 , Pages 959-964 , October 2009

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