« Previous
Next »
The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 3
, Pages 744-751
, September 2009
Renoprotective immunosuppression by pioglitazone with low-dose cyclosporine in rat heart transplantation
References
- . Organ transplantation—how much of the promise has been realized?. Nat Med. 2005;11:605–613
- . Heart and lung transplantation in the United States, 1997-2006. Am J Transplant. 2008;8(suppl):977–987
- . Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity. Clin Transplant. 2008;22:1–15
- Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med. 2003;349:931–940
- Biotransformation enzymes and drug transporters pharmacogenetics in relation to immunosuppressive drugs: impact on pharmacokinetics and clinical outcome. Transplantation. 2008;85(suppl):S19–S24
- Low-dose cyclosporine with mycophenolate mofetil induces similar calcineurin activity and cytokine inhibition as does standard-dose cyclosporine in stable renal allografts. Transplantation. 2004;78:1400–1403
- . Sirolimus and mycophenolate mofetil as calcineurin inhibitor-free immunosuppression in a cardiac transplant patient with chronic renal failure. J Heart Lung Transplant. 2004;23:770–773
- Everolimus and reduced cyclosporine trough levels in maintenance heart transplant recipients. Transpl Immunol. 2006;16:46–51
- . Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock. Cardiovasc Res. 2005;65:772–781
- Pioglitazone attenuates neointimal thickening via suppression of the early inflammatory response in a porcine coronary after stenting. Atherosclerosis. 2008;197:612–619
- Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. Heart. 2005;91:1203–1208
- A pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy. Kidney Int. 2005;68:285–292
- Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation. Am J Physiol Renal Physiol. 2007;292:F1141–F1150
- . Protection of the kidney by thiazolidinediones: an assessment from bench to bedside. Kidney Int. 2006;70:1223–1233
- . Pioglitazone prevents acute and chronic cardiac allograft rejection. Circulation. 2006;113:2613–2622
- Pereira MG, Camara NO, Campaholle G, Cenedeze MA, de Paula AT, V, dos Reis MA, et al. Pioglitazone limits cyclosporine nephrotoxicity in rats. Int Immunopharmacol. 2006;6:1943-1951.
- . Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 1969;57:225–229
- A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant. 1990;9:587–593
- Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710–1720
- . Evidence that calcineurin is rate-limiting for primary human lymphocyte activation. J Clin Invest. 1997;100:1894–1901
- . Mechanism of a clinically relevant protocol to induce tolerance of cardiac allografts. Perioperative donor spleen cells plus cyclosporine suppress IL-2 and interferon-gamma production. Transplantation. 1993;56:1309–1314
- Role of transforming growth factor-beta 1 in experimental chronic cyclosporine nephropathy. Kidney Int. 1996;49:1141–1151
- PPAR-gamma agonist protects podocytes from injury. Kidney Int. 2007;71:1232–1239
- . Effect of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on ischemia-reperfusion injury in rats. Pharmacology. 2007;79:184–192
- Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB J. 2002;16:1027–1040
- In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Circulation. 2001;104:2588–2594
- . Role of PPAR-gamma on the pathogenesis and vascular changes in glycerol-induced acute renal failure. Pharmacol Res. 2006;54:234–240
- . Rosiglitazone increases PPARgamma in renal tubular epithelial cells and protects against damage by hydrogen peroxide. Am J Nephrol. 2007;27:425–434
- . TGF-beta signaling in renal disease. J Am Soc Nephrol. 2002;13:2600–2610
- Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest. 2001;108:807–816
- . Transforming growth factor beta in tissue fibrosis. N Engl J Med. 1994;331:1286–1292
- . In vivo hyperexpression of transforming growth factor-beta1 in mice: stimulation by cyclosporine. Transplantation. 1997;63:1037–1039
- Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem. 2001;276:45888–45894
- Pioglitazone inhibits in-stent restenosis in atherosclerotic rabbits by targeting transforming growth factor-beta and MCP-1. Arterioscler Thromb Vasc Biol. 2007;27:182–189
- . The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. J Immunol. 2000;164:1364–1371
- Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation. 2002;106:3126–3132
- Effects of early steroid withdrawal after heart transplantation. Ann Thorac Surg. 2006;82:637–644
Supported by a Japan Heart Foundation research grant.
PII: S0022-5223(09)00644-8
doi: 10.1016/j.jtcvs.2009.04.019
© 2009 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 3
, Pages 744-751
, September 2009
