The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 2 , Pages 405-411 , August 2009

Extrapleural pneumonectomy followed by intracavitary intraoperative hyperthermic cisplatin with pharmacologic cytoprotection for treatment of malignant pleural mesothelioma: A phase II prospective study

  • Tamara R. Tilleman, MD, PhD

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • ,
  • William G. Richards, PhD

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • ,
  • Lambros Zellos, MD, MPH

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • ,
  • Bruce E. Johnson, MD

      Affiliations

    • Dana Farber Cancer Institute, Boston, Mass
    • ,
  • Michael T. Jaklitsch, MD

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • ,
  • Jordan Mueller

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • ,
  • Beow Yong Yeap, ScD

      Affiliations

    • Department of Medicine, Massachusetts General Hospital, Boston, Mass
    • ,
  • Aneil A. Mujoomdar, MD

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • ,
  • Christopher T. Ducko, MD

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • ,
  • Raphael Bueno, MD

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • ,
  • David J. Sugarbaker, MD

      Affiliations

    • Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass
    • Corresponding Author InformationAddress for reprints: David J. Sugarbaker, MD, Division of Thoracic Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.

Received 15 May 2008 ,Revised 9 January 2009 ,Accepted 23 February 2009.

References 

  1. Metintas M, Ucgun I, Elbek O, Erginel S, Metintas S, Kolsuz M, et al. Computed tomography features in malignant pleural mesothelioma and other commonly seen pleural diseases. Eur J Radiol. 2002;41:1–9
  2. Tossavainen A. Global use of asbestos and the incidence of mesothelioma. Int J Occup Environ Health. 2004;10:22–25
  3. Goudar RK. New therapeutic options for mesothelioma. Curr Oncol Rep. 2005;7:260–265
  4. Sugarbaker DJ. Macroscopic complete resection: the goal of primary surgery in multimodality therapy for pleural mesothelioma. J Thorac Oncol. 2006;1:175–176
  5. Worn H. Chances and results of surgery of malignant mesothelioma of the pleura. Thoraxchir Vask Chir. 1974;22:391–393
  6. Butchart EG, Ashcroft T, Barnsley WC, Holden MP. Pleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura. Experience with 29 patients. Thorax. 1976;31:15–24
  7. Sugarbaker DJ, Flores RM, Jaklitsch MT, Richards WG, Strauss GM, Corson JM, et al. Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients. J Thorac Cardiovasc Surg. 1999;117:54–65
  8. Flores RM, Pass HI, Seshan VE, Dycoco J, Zakowski M, Carbone M, et al. Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients. J Thorac Cardiovasc Surg. 2008;135:620–626e1-3
  9. Rice DC, Stevens CW, Correa AM, Vaporciyan AA, Tsao A, Forster KM, et al. Outcomes after extrapleural pneumonectomy and intensity-modulated radiation therapy for malignant pleural mesothelioma. Ann Thorac Surg. 2007;84:1685–1693
  10. Richards WG, Zellos L, Bueno R, Jaklitsch MT, Janne PA, Chirieac LR, et al. Phase I to II study of pleurectomy/decortication and intraoperative intracavitary hyperthermic cisplatin lavage for mesothelioma. J Clin Oncol. 2006;24:1561–1567
  11. Sugarbaker DJ, Jaklitsch MT, Bueno R, Richards W, Lukanich J, Mentzer SJ, et al. Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomies. J Thorac Cardiovasc Surg. 2004;128:138–146
  12. Flores RM, Krug LM, Rosenzweig KE, Venkatraman E, Vincent A, Heelan R, et al. Induction chemotherapy, extrapleural pneumonectomy, and postoperative high-dose radiotherapy for locally advanced malignant pleural mesothelioma: a phase II trial. J Thorac Oncol. 2006;1:289–295
  13. Pass HI, Temeck BK, Kranda K, Thomas G, Russo A, Smith P, et al. Phase III randomized trial of surgery with or without intraoperative photodynamic therapy and postoperative immunochemotherapy for malignant pleural mesothelioma. Ann Surg Oncol. 1997;4:628–633
  14. Baldini EH, Recht A, Strauss GM, DeCamp MM, Swanson SJ, Liptay MJ, et al. Patterns of failure after trimodality therapy for malignant pleural mesothelioma. Ann Thorac Surg. 1997;63:334–338
  15. Gupta V, Mychalczak B, Krug L, Flores R, Bains M, Rusch VW, et al. Hemithoracic radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 2005;63:1045–1052
  16. Friedberg JS, Mick R, Stevenson J, Metz J, Zhu T, Buyske J, et al. A phase I study of Foscan-mediated photodynamic therapy and surgery in patients with mesothelioma. Ann Thorac Surg. 2003;75:952–959
  17. Chang MY, Sugarbaker DJ. Extrapleural pneumonectomy for diffuse malignant pleural mesothelioma: techniques and complications. Thorac Surg Clin. 2004;14:523–530
  18. Zellos L, Richards WG, Capalbo L, Jaklitsch MT, Chirieac LR, Johnson BE, et al. A phase I study of extrapleural pneumonectomy and intracavitary intraoperative hyperthermic cisplatin with amifostine cytoprotection for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2009;137:453–458
  19. Sugarbaker DJ, Mentzer SJ, Strauss G. Extrapleural pneumonectomy in the treatment of malignant pleural mesothelioma. Ann Thorac Surg. 1992;54:941–946
  20. Markman M, Cleary S, Howell SB. Nephrotoxicity of high-dose intracavitary cisplatin with intravenous thiosulfate protection. Eur J Cancer Clin Oncol. 1985;21:1015–1018
  21. Hensley ML, Schuchter LM, Lindley C, Meropol NJ, Cohen GI, Broder G, et al. American Society of Clinical Oncology clinical practice guidelines for the use of chemotherapy and radiotherapy protectants. J Clin Oncol. 1999;17:3333–3355
  22. Sugarbaker DJ, Garcia JP, Richards WG, Harpole DH, Healy-Baldini E, DeCamp MM, et al. Extrapleural pneumonectomy in the multimodality therapy of malignant pleural mesothelioma. Results in 120 consecutive patients. Ann Surg. 1996;244:288–294
  23. Allen AM, Czerminska M, Janne PA, Sugarbaker DJ, Bueno R, Harris JR, et al. Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma. Int J Radiat Oncol Biol Phys. 2006;65:640–645
  24. Gray R. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat. 1988;16:1141–1154
  25. Okada M, Mimura T, Ohbayashi C, Sakuma T, Soejima T, Tsubota N. Radical surgery for malignant pleural mesothelioma: results and prognosis. Interact Cardiovasc Thorac Surg. 2008;7:102–106
  26. Rusch VW, Venkatraman E. The importance of surgical staging in the treatment of malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 1996;111:815–826
  27. Richards WG, Zellos L, Bueno R, Hartigan P, Sugarbaker DJ. Sequential amifostine and sodium thiosulfate improve renal protection during intracavitary high-dose cisplatin lavage. Presented at: 8th International Conference of the International Mesothelioma Interest Group; Chicago, Ill; 2006.
  28. Ellis P, Davies AM, Evans WK, Haynes AE, Lloyd NS. The use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline. J Thorac Oncol. 2006;1:591–601
  29. van Meerbeeck JP, Gaafar R, Manegold C, Van Klaveren RJ, Van Marck EA, Vincent M, et al. Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. J Clin Oncol. 2005;23:6881–6889
  30. Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003;21:2636–2644

 Read at the Eighty-eighth Annual Meeting of The American Association for Thoracic Surgery, San Diego, Calif, May 10–14, 2008.

PII: S0022-5223(09)00466-8

doi: 10.1016/j.jtcvs.2009.02.046

The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 2 , Pages 405-411 , August 2009

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