The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 2 , Pages 374-381 , August 2009

Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease

  • Janet S. Soul, MD, CM

      Affiliations

    • Department of Neurology, at Children's Hospital Boston, Boston, Mass
    • Department of Neurology, at Harvard Medical School, Boston, Mass
    • Corresponding Author InformationAddress for reprints: Janet S. Soul, MD, CM, Department of Neurology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115.
    • ,
  • Richard L. Robertson, MD

      Affiliations

    • Department of Radiology, at Children's Hospital Boston, Boston, Mass
    • Department of Radiology, at Harvard Medical School, Boston, Mass
    • ,
  • David Wypij, PhD

      Affiliations

    • Department of Cardiology, at Children's Hospital Boston, Boston, Mass
    • Department of Pediatrics, at Harvard Medical School, Boston, Mass
    • Department of Biostatistics, Harvard School of Public Health, Boston, Mass
    • ,
  • David C. Bellinger, PhD, MSc

      Affiliations

    • Department of Neurology, at Children's Hospital Boston, Boston, Mass
    • Department of Neurology, at Harvard Medical School, Boston, Mass
    • ,
  • Karen J. Visconti, PhD

      Affiliations

    • Department of Cardiovascular Surgery, at Children's Hospital Boston, Boston, Mass
    • ,
  • Adré J. du Plessis, MBChB, MPH

      Affiliations

    • Department of Neurology, at Children's Hospital Boston, Boston, Mass
    • Department of Neurology, at Harvard Medical School, Boston, Mass
    • ,
  • Barry D. Kussman, MBBCh

      Affiliations

    • Department of Anesthesiology, at Children's Hospital Boston, Boston, Mass
    • Department of Anesthesia, at Harvard Medical School, Boston, Mass
    • ,
  • Lisa A. Scoppettuolo, MS

      Affiliations

    • Department of Cardiology, at Children's Hospital Boston, Boston, Mass
    • Department of Biostatistics, Harvard School of Public Health, Boston, Mass
    • ,
  • Frank Pigula, MD

      Affiliations

    • Department of Cardiovascular Surgery, at Children's Hospital Boston, Boston, Mass
    • Department of Surgery, at Harvard Medical School, Boston, Mass
    • ,
  • Richard A. Jonas, MD

      Affiliations

    • Department of Cardiovascular Surgery, at Children's Hospital Boston, Boston, Mass
    • Department of Surgery, at Harvard Medical School, Boston, Mass
    • ,
  • Jane W. Newburger, MD, MPH

      Affiliations

    • Department of Cardiology, at Children's Hospital Boston, Boston, Mass
    • Department of Pediatrics, at Harvard Medical School, Boston, Mass

Received 1 August 2008 ,Revised 13 November 2008 ,Accepted 9 February 2009.

References 

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  5. Bellinger DC, Wypij D, duDuplessis AJ, Rappaport LA, Jonas RA, Wernovsky G, et al. Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg. 2003;126:1385–1396
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 Supported by grants HL 063411 and RR 02172 from the National Institutes of Health.

 Registered with clinicaltrials.gov (#) NCT00006183.

 Dr Jonas is currently Chief of Cardiovascular Surgery and Co-Director of the Children's National Heart Institute, Washington, DC.

PII: S0022-5223(09)00331-6

doi: 10.1016/j.jtcvs.2009.02.027

The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 2 , Pages 374-381 , August 2009

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