The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 6 , Page 1573 , June 2009

Experimental ventricular pressure overload in young animals induces cardiomyocyte hypertrophy in addition to hyperplasia of contractile and noncontractile elements of the myocardium

  • Maria C.D. Abduch, VMD, PhD

      Affiliations

    • Laboratory of Echocardiography, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
    • ,
  • Renato S. Assad, MD, PhD

      Affiliations

    • Division of Surgical Research, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
    • ,
  • V.D. Aiello, MD, PhD

      Affiliations

    • Laboratory of Pathology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil

References 

  1. Assad RS, Cardarelli M, Abduch MC, et al. Reversible pulmonary trunk banding with a balloon catheter: assessment of rapid pulmonary ventricular hypertrophy. J Thorac Cardiovasc Surg. 2000;120:66–72
  2. Dias CA, Assad RS, Caneo LF, et al. Reversible pulmonary trunk banding II. An experimental model for rapid pulmonary ventricular hypertrophy. J Thorac Cardiovasc Surg. 2002;124:999–1006
  3. Abduch MC, Assad RS, Rodriguez MQ, et al. Reversible pulmonary trunk banding III: assessment of myocardial adaptive mechanisms—contribution of cell proliferation. J Thorac Cardiovasc Surg. 2007;133:1510–1516
  4. Leeuwenburgh BPJ, Helbing WA, Weninck ACG, et al. Chronic right ventricular pressure overload results in a hyperplastic rather than a hypertrophic myocardial response. J Anat. 2008;212:286–294
  5. Anversa P, Olivetti G, Loud AV. Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. Hypertrophy, hyperplasia and binucleation of myocytes. Circ Res. 1980;46:495–502

PII: S0022-5223(09)00218-9

doi: 10.1016/j.jtcvs.2009.01.021

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 6 , Page 1573 , June 2009

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