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The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5
, Pages 1249-1257
, May 2009
Long-acting oral phosphodiesterase inhibition preconditions against reperfusion injury in an experimental lung transplantation model
References
- Primary graft failure following lung transplantation. Chest. 1998;114:51–60
- Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. Ann Thorac Surg. 2000;69:1681–1685
- . Update of early respiratory failure in the lung transplant recipient. Curr Opin Crit Care. 2006;12:19–24
- Primary graft dysfunction and long-term pulmonary function after lung transplantation. J Heart Lung Transplant. 2007;26:1004–1011
- Risk factors for primary graft dysfunction after lung transplantation. J Thorac Cardiovasc Surg. 2006;131:73–80
- . Ischemia-reperfusion–induced lung injury. Am J Respir Crit Care Med. 2003;167:490–511
- Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2007;175:507–513
- . Inflammatory response to pulmonary ischemia-reperfusion injury. Surg Today. 2006;36:205–214
- . Endothelial adhesivity, pulmonary hemodynamics and nitric oxide synthesis in ischemia–reperfusion. Eur J Cardiothorac Surg. 2000;18:348–352
- The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs. Am J Physiol. 2000;279:L496–L502
- . Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas' hospital cardioplegic solution used for hypothermic preservation of rat lungs. Am J Respir Crit Care Med. 2000;162(3 Pt 1):850–856
- . Phosphodiesterase regulation of nitric oxide signaling. Cardiovasc Res. 2007;75:303–314
- . PDE-5 inhibitors: current status and future trends. Urol Clin North Am. 2005;32:511–525viii
- . IC351 (tadalafil, Cialis): update on clinical experience. Int J Impot Res. 2002;14(Suppl. 1):S57–S64
- Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction. Urology. 2006;68:689–696
- . PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation. Am J Physiol. 2008;294:L24–L33
- . Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase. Am J Physiol Heart Circ Physiol. 2007;292:H1340–H1351
- Exposure to inhaled particulate matter impairs cardiac function in senescent mice. Am J Physiol Regul Integr Comp Physiol. 2008;295:R252–R263
- Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood. 2007;109:3088–3098
- . Oxygen-dependent reperfusion injury in the isolated rat lung. J Appl Physiol. 1992;72:1454–1460
- Sildenafil extends survival and graft function in a large animal lung transplantation model. Eur J Cardiothorac Surg. 2006;29:288–293
- . PDE-5 inhibitor donor intravenous preconditioning is superior to supplementation in standard preservation solution in experimental lung transplantation. Eur J Cardiothorac Surg. 2007;32:42–47
- Normal gas exchange after 30-h ischemia and treatment with phosphodiesterase inhibitor PDI747. Eur J Cardiothorac Surg. 2003;24:594–600
- Pharmacological preconditioning with sildenafil: basic mechanisms and clinical implications. Vasc Pharmacol. 2005;42:219–232
- . eNOS phosphorylation: a pivotal molecular switch in vasodilation and cardioprotection?. J Mol Cell Cardiol. 2007;42:280–282
- . Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol. 2007;42:271–279
- . Cardiovascular protection with sildenafil following chronic inhibition of nitric oxide synthase. Br J Pharmacol. 2007;150:538–540
- Increased expression of nitric oxide synthase in human lung transplants after nitric oxide inhalation. Transplantation. 2004;77:886–890
- Alterations of nitric oxide synthase expression and activity during rat lung transplantation. Am J Physiol. 2000;278:L1071–L1081
- The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation. Proc Natl Acad Sci U S A. 1994;91:12086–12090
Supported by the Mildred and Carmont Blitz Cardiac Research Fund, the Joyce Koons Family Cardiac Endowment Fund, the American Medical Association Foundation (AMA seed grant, E.S.W.), and the National Institutes of Health (NIH 2T32DK007713-12 ESW). Eric Weiss and Jason Williams are Irene Piccinini Investigators in Cardiac Surgery. The study was also supported in part by an American Heart Association Scientist Development Grant, a grant from the W.W.Smith Charitable Trust, a Shih-Chun Wang Young Investigator Award; a Giles F. Filley Award of the American Physiological Society; the Bernard Family Foundation, and NIHP50HL084946 (H.C.C.).
Read at the Eighty-eighth Annual Meeting of The American Association for Thoracic Surgery, San Diego, Calif, May 10–14, 2008.
PII: S0022-5223(09)00032-4
doi: 10.1016/j.jtcvs.2008.12.040
© 2009 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.
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The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5
, Pages 1249-1257
, May 2009
