The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5 , Pages 1241-1248 , May 2009

Enhanced fibrinolysis protects against lung ischemia–reperfusion injury

  • Christine L. Lau, MD

      Affiliations

    • Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Va
    • ,
  • Yunge Zhao, MD, PhD

      Affiliations

    • Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Va
    • ,
  • Jiyoun Kim, PhD

      Affiliations

    • Department of Pathology, Boston University, Boston, Mass
    • ,
  • Irving L. Kron, MD

      Affiliations

    • Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Va
    • ,
  • Ashish Sharma, MBBS

      Affiliations

    • Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Va
    • ,
  • Zequan Yang, MD, PhD

      Affiliations

    • Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Va
    • ,
  • Victor E. Laubach, PhD

      Affiliations

    • Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Va
    • ,
  • Joel Linden, PhD

      Affiliations

    • Department of Internal Medicine, University of Virginia, Charlottesville, Va
    • ,
  • Gorav Ailawadi, MD

      Affiliations

    • Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Va
    • Corresponding Author InformationAddress for reprints: Gorav Ailawadi, MD, PO Box 800679, Charlottesville, VA 22908-0679.
    • ,
  • David J. Pinsky, MD

      Affiliations

    • Department of Internal Medicine, Ann Arbor, Mich

Received 18 September 2008 ,Revised 18 November 2008 ,Accepted 25 December 2008.

References 

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  2. Christie JD, Kotloff RM, Pochettino A, Arcasoy SM, Rosengard BR, Landis JR, et al. Clinical risk factors for primary graft failure following lung transplantation. [see comment] Chest. 2003;124:1232–1241
  3. Daud SA, Yusen RD, Meyers BF, Chakinala MM, Walter MJ, Aloush AA, et al. Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2007;175:507–513
  4. Fiser SM, Tribble CG, Long SM, Kaza AK, Kern JA, Jones DR, et al. Ischemia–reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome. Ann Thorac Surg. 2002;73:1041–1047discussion 1047-8
  5. Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006;291:L307–L311
  6. Idell S. Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med. 2003;31(4 Suppl):S213–S220
  7. Pinsky DJ, Liao H, Lawson CA, Yan SF, Chen J, Carmeliet P, et al. Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest. 1998;102:919–928
  8. Zhao M, Fernandez LG, Doctor A, Sharma AK, Zarbock A, Tribble CG, et al. Alveolar macrophage activation is a key initiation signal for acute lung ischemia–reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2006;291:L1018–L1026
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  10. Zhao Y-G, Xiao A-Z, Park HI, Newcomer RG, Yan M, Man Y-G, et al. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. Cancer Res. 2004;64:590–598
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  13. Okada K, Fujita T, Minamoto K, Liao H, Naka Y, Pinsky DJ. Potentiation of endogenous fibrinolysis and rescue from lung ischemia/reperfusion injury in interleukin (IL)-10-reconstituted IL-10 null mice. J Biol Chem. 2000;275:21468–21476
  14. Farivar A, Delgado M, McCourtie A, Barnes A, Verrier E, Mulligan MS. Crosstalk between thrombosis and inflammation in lung reperfusion injury. Ann Thorac Surg. 2006;81:1061–1067
  15. Christie JD, Robinson N, Ware LB, Plotnick M, De Andrade J, Lama V, et al. Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction. Am J Respir Crit Care Med. 2007;175:69–74
  16. Moalli R, Doyle JM, Tahhan HR, Hasan FM, Braman SS, Saldeen T. Fibrinolysis in critically ill patients. Am Rev Respir Dis. 1989;140:287–293
  17. Brown NJ, Agirbasli M, Vaughan DE. Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans. Hypertension. 1999;34:285–290
  18. Vaughan DE, Rouleau JL, Ridker PM, Arnold JM, Menapace FJ, Pfeffer MA. Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators. Circulation. 1997;96:442–447

 Presented in part at the Twenty-eighth Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, Boston Mass, April 9–12, 2008.

 Dr Lau was supported by The American Association for Thoracic Surgery John W. Kirklin Fellowship (2006–2008) for this research.

PII: S0022-5223(09)00017-8

doi: 10.1016/j.jtcvs.2008.12.029

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5 , Pages 1241-1248 , May 2009

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