The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 6 , Pages 1499-1507 , June 2009

Keratinocyte growth factor accelerates compensatory growth in the remaining lung after trilobectomy in rats

  • Keitaro Matsumoto, MD

      Affiliations

    • Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Takeshi Nagayasu, MD

      Affiliations

    • Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Yoshitaka Hishikawa, MD

      Affiliations

    • Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Tsutomu Tagawa, MD

      Affiliations

    • Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Takatomo Yamayoshi, MD

      Affiliations

    • Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Takafumi Abo, MD

      Affiliations

    • Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Shuichi Tobinaga, MD

      Affiliations

    • Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Katsuro Furukawa, MD

      Affiliations

    • Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Takehiko Koji, PhD

      Affiliations

    • Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • Corresponding Author InformationAddress for reprints: Takehiko Koji, PhD, Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-12-4, Nagasaki 852-8523, Japan.

Received 2 March 2008 ,Revised 27 October 2008 ,Accepted 22 November 2008.

References 

  1. Kaza AK, Kron IL, Kern JA, Long SM, Fiser SM, Nguyen RP, et al. Retinoic acid enhances lung growth after pneumonectomy. Ann Thorac Surg. 2001;71:1645–1650
  2. Voswinckel R, Motejl V, Fehrenbach A, Wegmann M, Mehling T, Fehrenbach H, et al. Characterisation of post-pneumonectomy lung growth in adult mice. Eur Respir J. 2004;24:524–532
  3. Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A. 1989;86:802–806
  4. Barton CC, Bucci TJ, Lomax LG, Warbritton AG, Mehendale HM. Stimulated pulmonary cell hyperplasia underlies resistance to α-naphthylthiourea. Toxicology. 2000;143:167–181
  5. Kaza AK, Kron IL, Leuwerke SM, Tribble CG, Laubach VE. Keratinocyte growth factor enhances post-pneumonectomy lung growth by alveolar proliferation. Circulation. 2002;106(suppl 1):I120–I124
  6. Suzuki T, Shin BC, Fujikura K, Matsuzaki T, Takata K. Direct gene transfer into rat liver cells by in vivo electroporation. FEBS Lett. 1998;425:436–440
  7. Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell. Science. 1989;245:752–755
  8. Yamayoshi T, Nagayasu T, Matsumoto K, Abo T, Hishikawa Y, Koji T. Expression of keratinocyte growth factor/fibroblast growth factor-7 and its receptor in human lung cancer: correlation with tumour proliferative activity and patient prognosis. J Pathol. 2004;204:110–118
  9. Yamamoto-Fukuda T, Aoki D, Hishikawa Y, Kobayashi T, Takahashi H, Koji T. Possible involvement of keratinocyte growth factor and its receptor in enhanced epithelial-cell proliferation and acquired recurrence of middle-ear cholesteatoma. Lab Invest. 2003;83:123–136
  10. Shukuwa K, Izum S, Hishikawa Y, Ejima K, Inoue S, Muramatsu M, et al. Diethylstilbestrol increases the density of prolactin cells in male mouse pituitary by inducing proliferation of prolactin cells and transdifferentiation of gonadotropic cells. Histochem Cell Biol. 2006;126:111–123
  11. Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan AM, et al. Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A. 1992;89:246–250
  12. Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, et al. Keratinocyte growth factor and its receptor are involved in regulating early lung branching. Development. 1996;122:3107–3115
  13. Dell KR, Williams LT. A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity. J Biol Chem. 1992;267:21225–21229
  14. Massaro D, Massaro GD. Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice. Am J Physiol Lung Cell Mol Physiol. 2004;287:L1154–L1159
  15. Ulich TR, Yi ES, Longmuir K, Yin S, Blitz R, Morris CF, et al. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J Clin Invest. 1994;93:1298–1306
  16. Panos RJ, Rubin JS, Aaronson SA, Mason RJ. Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest. 1993;92:969–977
  17. Tamaru N, Hishikawa Y, Ejima K, Nagasue N, Inoue S, Muramatsu M, et al. Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of apoptosis in human breast cancer. Lab Invest. 2004;84:1460–1471
  18. Morino S, Nakamura T, Toba T, Takahashi M, Kushibiki T, Tabata Y, et al. Fibroblast growth factor-2 induces recovery of pulmonary blood flow in canine emphysema models. Chest. 2005;128:920–926
  19. Sakamaki Y, Matsumoto K, Mizuno S, Miyoshi S, Matsuda H, Nakamura T. Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice. Am J Respir Cell Mol Biol. 2002;26:525–533
  20. Ohmichi H, Koshimizu U, Matsumoto K, Nakamura T. Hepatocyte growth factor (HGF) acts as a mesenchyme-derived morphogenic factor during fetal lung development. Development. 1998;125:1315–1324
  21. Foster DJ, Yan X, Bellotto DJ, Moe OW, Hagler HK, Estrera AS, et al. Expression of epidermal growth factor and surfactant proteins during postnatal and compensatory lung growth. Am J Physiol Lung Cell Mol Physiol. 2002;283:L981–L990
  22. Muratore CS, Nguyen HT, Ziegler MM, Wilson JM. Stretch-induced upregulation of VEGF gene expression in murine pulmonary culture: a role for angiogenesis in lung development. J Pediatr Surg. 2000;35:906–912
  23. Yew NS, Przybylska M, Ziegler RJ, Liu D, Cheng SH. High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter. Mol Ther. 2001;4:75–82

PII: S0022-5223(08)02047-3

doi: 10.1016/j.jtcvs.2008.11.037

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 6 , Pages 1499-1507 , June 2009

Article Tools

* Image Usage & Resolution