The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 790-792 , March 2010

Treatment of heparin-induced thrombocytopenia after cardiac surgery: Preliminary experience with fondaparinux

  • Federico Pappalardo, MD

      Affiliations

    • Department of Cardiovascular Anesthesia and Intensive Care, IRCCS San Raffaele Hospital, Milan, Italy
    • Corresponding Author InformationAddress for reprints: Federico Pappalardo, MD, Department of Cardiovascular Anesthesia and Intensive Care, IRCCS San Raffaele Hospital, Via Olgettina, 60, 20132 Milan, Italy.
    • ,
  • Annamara Scandroglio, MD

      Affiliations

    • Department of Cardiovascular Anesthesia and Intensive Care, IRCCS San Raffaele Hospital, Milan, Italy
    • ,
  • Giulia Maj, MD

      Affiliations

    • Department of Cardiovascular Anesthesia and Intensive Care, IRCCS San Raffaele Hospital, Milan, Italy
    • ,
  • Alberto Zangrillo, MD

      Affiliations

    • Department of Cardiovascular Anesthesia and Intensive Care, IRCCS San Raffaele Hospital, Milan, Italy
    • ,
  • Armando D'Angelo, MD

      Affiliations

    • Coagulation Service and Thrombosis Research Unit, IRCCS San Raffaele Hospital, Milan, Italy

Received 22 February 2008 ,Accepted 16 November 2008.

References 

  1. Papadopoulos S, Flynn JD, Lewis DA. Fondaparinux as a treatment option for heparin-induced thrombocytopenia. Pharmacotherapy. 2007;27:921–926
  2. Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment and prevention: the Seventh ACCP Conference on Antithrombotic and thrombolytic therapy. Chest. 2005;127:416
  3. Ansell J. Factor Xa or thrombin: is factor Xa a better target?. J Thromb Haemost. 2007;5(Suppl 1):60–64
  4. Grand'Maison A, Charest AF, Geerts WH. Anticoagulant use in patients with chronic renal failure. Am J Cardiovasc Drugs. 2005;5:291–305
  5. Fox KA, Bassand JP, Mehta SR, et al. Oasis 5 Investigators. Influence of renal function on the efficacy and safety of fondaparinux relative to enoxaparin in non ST segment elevation acute coronary syndromes. Ann Intern Med. 2007;147:304–310

 Disclosures: None.

PII: S0022-5223(08)02045-X

doi: 10.1016/j.jtcvs.2008.11.032

The Journal of Thoracic and Cardiovascular Surgery
Volume 139, Issue 3 , Pages 790-792 , March 2010

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