Dimensional analysis of human saphenous vein grafts: Implications for external mesh support

Objective

Constrictive external mesh support of vein grafts was shown to mitigate intimal hyperplasia in animal experiments. To determine the degree of constriction required for the elimination of dimensional irregularities in clinically used vein grafts, a detailed anatomic study of human saphenous veins was conducted.

Methods

In 200 consecutive patients having coronary artery bypass grafting, harvested saphenous veins (length 34.4 ± 10.8 cm) were analyzed regarding diameter irregularities, side branch distribution, and microstructure.

Results

The mean outer diameter of surgically distended saphenous veins was 4.2 ± 0.6 mm (men, 4.3 ± 0.6 mm vs women, 3.9 ± 0.5 mm; P < .0001). Although the outer diameter significantly decreased over the initial 18 cm (−7.6%; P < .0001), the overall increase between malleolus and thigh was not significant (+11.2%). Smaller-diameter veins (<3.5 mm) had more pronounced diameter fluctuations than larger veins (31.8% ± 11.0% vs 21.2% ± 8.8%; P < .0001), with more than 71% of all veins showing caliber changes of more than 20%. There was 1 side branch every 5.4 ± 4.3 cm, with a significantly higher incidence between 20 and 32 cm from the malleolus (P < .0001 to distal, P < .0004 to proximal). Generally, women had more side branches than men (0.30 ± 0.15 cm⁻¹ vs 0.25 ± 0.12 cm⁻¹; P = .0190). Thick-walled veins (565.7 ± 138.4 μm) had a significantly higher number of large side branches (P < .0001), and thin-walled veins (398.7 ± 123.2 μm) had significantly more small side branches (P < .0001). Pronounced intimal thickening (“cushions”) was found in 28% of vessels (119.8 ± 28.0 μm vs 40.1 ± 18.2 μm; P < .0001).

Conclusion

Although the preferential location of side branches may be addressed by the deliberate discarding of infragenicular vein segments, a diameter constriction of 27% on average would eliminate diameter irregularities in 98% of vein grafts.

CTSNet classification: 23, 33

Abbreviations and Acronyms: BMI, body mass index, CABG, coronary artery bypass grafting, OD, outer diameter