The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5 , Pages 1206-1212 , May 2009

Myocardial revascularization with miniaturized extracorporeal circulation versus off pump: Evaluation of systemic and myocardial inflammatory response in a prospective randomized study

  • Francesco Formica, MD

      Affiliations

    • Cardiac Surgery Clinic, Department of Surgical Science, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
    • Corresponding Author InformationAddress for reprints: Francesco Formica, MD, Clinica Cardiochirurgica, Ospedale San Gerardo, Via Pergolesi 33, 20052, Monza (MI) Italy.
    • ,
  • Francesco Broccolo, MD

      Affiliations

    • Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milan, Italy
    • ,
  • Antonello Martino, MD

      Affiliations

    • Cardiac Surgery Clinic, Department of Surgical Science, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
    • ,
  • Jennifer Sciucchetti, MD

      Affiliations

    • Cardiac Surgery Clinic, Department of Surgical Science, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
    • ,
  • Vincenzo Giordano, MD

      Affiliations

    • Cardiac Surgery Clinic, Department of Surgical Science, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
    • ,
  • Leonello Avalli, MD

      Affiliations

    • Cardiac Surgery Intensive Care, San Gerardo Hospital, Monza, Italy
    • ,
  • Gianluigi Radaelli, MD

      Affiliations

    • Cardiac Surgery Intensive Care, San Gerardo Hospital, Monza, Italy
    • ,
  • Orazio Ferro, MD

      Affiliations

    • Cardiac Surgery Clinic, Department of Surgical Science, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
    • ,
  • Fabrizio Corti, MD

      Affiliations

    • Cardiac Surgery Clinic, Department of Surgical Science, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
    • ,
  • Clementina Cocuzza, MD, PhD

      Affiliations

    • Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milan, Italy
    • ,
  • Giovanni Paolini, MD, PhD

      Affiliations

    • Cardiac Surgery Clinic, Department of Surgical Science, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy

Received 26 February 2008 ,Revised 6 September 2008 ,Accepted 19 September 2008.

  • Image Result

    A, Time course of IL-6 in patients undergoing OPCABG or MECC. B, Time course of TNF-α in patients undergoing OPCABG or MECC. T0 = before CPB initiation in MECC group or before the first distal anastom

    A, Time course of IL-6 in patients undergoing OPCABG or MECC. B, Time course of TNF-α in patients undergoing OPCABG or MECC. T0 = before CPB initiation in MECC group or before the first distal anastomosis in OPCABG group; T1 = 5 minutes after aortic clamp removal in MECC group or 5 minutes after the last distal anastomosis in OPCABG group; T2 = end of operation; T3 = 24 hours; T4 = 48 hours. Data are expressed as means ± standard error of the mean (SEM). IL, Interleukin; TNF, tumor necrosis factor.

  • Image Result
    A, Arteriovenous difference of IL-6-from CS in patients undergoing OPCABG or MECC. B, Arteriovenous difference of TNF-α-from CS in patients undergoing OPCABG or MECC. T0 = before CPB initiation in MEC

    A, Arteriovenous difference of IL-6-from CS in patients undergoing OPCABG or MECC. B, Arteriovenous difference of TNF-α-from CS in patients undergoing OPCABG or MECC. T0 = before CPB initiation in MECC group or before the first distal anastomosis in OPCABG group; T1 = 5 minutes after aortic clamp removal in MECC group or 5 minutes after the last distal anastomosis in OPCABG group. Data are expressed as means ± SEM. IL, Interleukin; TNF, tumor necrosis factor.

  • Image Result
    Time course of monocyte count in patients undergoing OPCABG or MECC. T0 = preoperative; T1 = end of operation; T2 = 24 hours; T3 = 48 hours. Data are expressed as means ± SEM.

    Time course of monocyte count in patients undergoing OPCABG or MECC. T0 = preoperative; T1 = end of operation; T2 = 24 hours; T3 = 48 hours. Data are expressed as means ± SEM.

  • Image Result
    A, Time course of systemic blood lactate in patients undergoing OPCABG or MECC. T0 = before CPB initiation in MECC group or before the first distal anastomosis in OPCABG group; T1 = 5 minutes after ao

    A, Time course of systemic blood lactate in patients undergoing OPCABG or MECC. T0 = before CPB initiation in MECC group or before the first distal anastomosis in OPCABG group; T1 = 5 minutes after aortic clamp removal in MECC group or 5 minutes after the last distal anastomosis in OPCABG group; T2 = end of operation; T3, = 12 hours; T4 = 24 hours; T5 = 48 hours. B, Time course of blood lactate from CS in patients undergoing OPCABG or MECC. T0 = before CPB initiation in MECC group or before the first distal anastomosis in OPCABG group; T1 = 5 minutes after aortic clamp removal in MECC group or 5 minutes after the last distal anastomosis in OPCABG group. Data are expressed as means ± SEM.

PII: S0022-5223(08)01872-2

doi: 10.1016/j.jtcvs.2008.09.074

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5 , Pages 1206-1212 , May 2009

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