The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 6 , Pages 1445-1447 , December 2009

Shedding of the endothelial glycocalyx during cardiac surgery: On-pump versus off-pump coronary artery bypass graft surgery

  • Dirk Bruegger, MD

      Affiliations

    • Clinic of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
    • D.B. and M.R. contributed equally to this article.
    • Corresponding Author InformationAddress for reprints: Dirk Bruegger, MD, Clinic of Anesthesiology, Ludwig-Maximilians-University, Marchioninistr. 15, D-81377 Munich, Germany.
    • ,
  • Markus Rehm, MD

      Affiliations

    • Clinic of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
    • D.B. and M.R. contributed equally to this article.
    • ,
  • Jan Abicht, MD

      Affiliations

    • Clinic of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Joern Oliver Paul, MD

      Affiliations

    • Clinic of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Mechthild Stoeckelhuber, MD, PhD

      Affiliations

    • Department of Anatomy, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Markus Pfirrmann, MSc

      Affiliations

    • Department of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Bruno Reichart, MD

      Affiliations

    • Department of Cardiac Surgery, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Bernhard F. Becker, MD, PhD

      Affiliations

    • Institute of Physiology, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Frank Christ, MD

      Affiliations

    • Clinic of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany

Received 8 July 2008 ,Revised 22 July 2008

References 

  1. Pries AR, Secomb TW, Gaehtgens P. The endothelial surface layer. Pflugers Arch. 2000;440:653–666
  2. Reitsma S, Slaaf DW, Vink H, van Zandvoort MA, oude Egbrink MG. The endothelial glycocalyx: composition, functions, and visualization. Pflugers Arch. 2007;454:345–359
  3. Rehm M, Bruegger D, Christ F, Conzen P, Thiel M, Jacob M, et al. Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation. 2007;116:1896–1906
  4. Bruegger D, Jacob M, Rehm M, Loetsch M, Welsch U, Conzen P, et al. Atrial natriuretic peptide induces shedding of the endothelial glycocalyx in the coronary vascular bed of guinea pig hearts. Am J Physiol Heart Circ Physiol. 2005;289:H1993–H1999

 This work was performed with departmental research funding provided by the Government of Bavaria (Bavarian State Ministry of Science, Research, and the Arts, Munich, Germany) and a grant provided by the Friedrich-Baur-Stiftung, Munich, Germany.

PII: S0022-5223(08)01761-3

doi: 10.1016/j.jtcvs.2008.07.063

The Journal of Thoracic and Cardiovascular Surgery
Volume 138, Issue 6 , Pages 1445-1447 , December 2009

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