The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5 , Pages 1234-1240.e1 , May 2009

Matching donor to recipient in lung transplantation: How much does size matter?

  • David P. Mason, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationAddress for reprints: David P. Mason, MD, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Avenue/Desk J4-1, Cleveland, OH 44195.
    • ,
  • Lillian H. Batizy, MS

      Affiliations

    • Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Jeffrey Wu, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Edward R. Nowicki, MD, MS

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Sudish C. Murthy, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Ann M. McNeill, RN

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Marie M. Budev, DO

      Affiliations

    • Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Atul C. Mehta, MD

      Affiliations

    • Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Gösta B. Pettersson, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Eugene H. Blackstone, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
    • Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio

Received 9 May 2008 ,Revised 11 August 2008 ,Accepted 26 October 2008.

References 

  1. Aigner C, Jaksch P, Taghavi S, Wisser W, Marta G, Winkler G, et al. Donor total lung capacity predicts recipient total lung capacity after size-reduced lung transplantation. J Heart Lung Transplant. 2005;24:2098–2102
  2. Date H, Aoe M, Nagahiro I, Sano Y, Matsubara H, Goto K, et al. How to predict forced vital capacity after living-donor lobar-lung transplantation. J Heart Lung Transplant. 2004;23:547–551
  3. Egan TM, Thompson JT, Detterbeck FC, Lackner RP, Mill MR, Ogden WD, et al. Effect of size (mis)matching in clinical double-lung transplantation. Transplantation. 1995;59:707–713
  4. Ouwens JP, van der Mark TW, van der Bij W, Geertsma A, de Boer WJ, Koeter GH. Size matching in lung transplantation using predicted total lung capacity. Eur Respir J. 2002;20:1419–1422
  5. Daly RC, McGregor CG. Surgical issues in lung transplantation: options, donor selection, graft preservation, and airway healing. Mayo Clin Proc. 1997;72:79–84
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  7. Park SJ, Houck J, Pifarre R, Sullivan H, Garrity E, Kim SY, et al. Optimal size matching in single lung transplantation. J Heart Lung Transplant. 1995;14:671–675
  8. Miyoshi S, Demertzis S, Eckstein F, Hohlfeld J, Schaefers HJ. Chest size matching in single and double lung transplantation. Jpn J Thorac Cardiovasc Surg. 1999;47:163–170
  9. Standardization of Spirometry, 1994 Update . American Thoracic Society. Am J Respir Crit Care Med. 1995;152:1107–1136
  10. Clayton N. Lung function made easy: assessing lung size. Chron Respir Dis. 2007;4:151–157
  11. Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, et al. Standardisation of the measurement of lung volumes. Eur Respir J. 2005;26:511–522
  12. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159:179–187
  13. Blackstone EH, Naftel DC, Turner ME. The decomposition of time-varying hazard into phases, each incorporating a separate stream of concomitant information. J Am Stat Assoc. 1986;81:615–624
  14. Breiman L. Bagging predictors. Machine Learning. 1996;24:123–140
  15. Mason DP, Rajeswaran J, Murthy SC, McNeill AM, Budev MM, Mehta AC, et al. Spirometry after transplantation: how much better are two lungs than one?. Ann Thorac Surg. 2008;85:1193–12011201.e1-2
  16. Ingenito EP, Loring SH, Moy ML, Mentzer SJ, Swanson SJ, Reilly JJ. Physiological characterization of variability in response to lung volume reduction surgery. J Appl Physiol. 2003;94:20–30
  17. Loring SH, Mentzer SJ, Reilly JJ. Sources of graft restriction after single lung transplantation for emphysema. J Thorac Cardiovasc Surg. 2007;134:204–209
  18. Cassart M, Verbandt Y, de Francquen P, Gevenois PA, Estenne M. Diaphragm dimensions after single-lung transplantation for emphysema. Am J Respir Crit Care Med. 1999;159:1992–1997
  19. Pompeo E, Mineo TC. Two-year improvement in multidimensional body mass index, airflow obstruction, dyspnea, and exercise capacity index after nonresectional lung volume reduction surgery in awake patients. Ann Thorac Surg. 2007;84:1862–1869
  20. Aigner C, Winkler G, Jaksch P, Ankersmit J, Marta G, Taghavi S, et al. Size-reduced lung transplantation: an advanced operative strategy to alleviate donor organ shortage. Transplant Proc. 2004;36:2801–2805
  21. Oto T, Date H, Hayama M, Ando A, Shimizu N. Peripheral lung volume reduction improved early graft function in severe size mismatched living donor lobar lung transplantation. Transplant Proc. 2005;37:4515–4521
  22. Backhus LM, Sievers EM, Schenkel FA, Barr ML, Cohen RG, Smith MA, et al. Pleural space problems after living lobar transplantation. J Heart Lung Transplant. 2005;24:2086–2090
  23. Boffa DJ, Mason DP, Su JW, Murthy SC, Feng J, McNeill AM, et al. Decortication after lung transplantation. Ann Thorac Surg. 2008;85:1039–1043
  24. Herridge MS, de Hoyos AL, Chaparro C, Winton TL, Kesten S, Maurer JR. Pleural complications in lung transplant recipients. J Thorac Cardiovasc Surg. 1995;110:22–26
  25. Bowdish ME, Pessotto R, Barbers RG, Schenkel FA, Starnes VA, Barr ML. Long-term pulmonary function after living-donor lobar lung transplantation in adults. Ann Thorac Surg. 2005;79:418–425
  26. Santos F, Lama R, Alvarez A, Algar FJ, Quero F, Cerezo F, et al. Pulmonary tailoring and lobar transplantation to overcome size disparities in lung transplantation. Transplant Proc. 2005;37:1526–1529

 Supported in part by the Kenneth Gee and Paula Shaw, PhD, Chair in Heart Research.

PII: S0022-5223(08)01750-9

doi: 10.1016/j.jtcvs.2008.10.024

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5 , Pages 1234-1240.e1 , May 2009

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