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Volume 137, Issue 5 , Pages 1234-1240.e1 , May 2009

Matching donor to recipient in lung transplantation: How much does size matter?

David P. Mason, MD
- Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
- Address for reprints: David P. Mason, MD, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Avenue/Desk J4-1, Cleveland, OH 44195.
Lillian H. Batizy, MS
- Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio
Jeffrey Wu, MD
- Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
Edward R. Nowicki, MD, MS
- Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
Sudish C. Murthy, MD, PhD
- Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
Ann M. McNeill, RN
- Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
Marie M. Budev, DO
- Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio
Atul C. Mehta, MD
- Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio
Gösta B. Pettersson, MD, PhD
- Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
Eugene H. Blackstone, MD
- Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
- Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio

Received 9 May 2008 ,Revised 11 August 2008 ,Accepted 26 October 2008.

Distribution of differences in aTLC versus pTLC by diagnosis. PAH, Pulmonary arterial hypertension; IPF, idiopathic pulmonary fibrosis; aTLC, actual total lung capacity; pTLC, predicted total lung cap

Distribution of differences in aTLC versus pTLC by diagnosis. PAH, Pulmonary arterial hypertension; IPF, idiopathic pulmonary fibrosis; aTLC, actual total lung capacity; pTLC, predicted total lung capacity.
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Cumulative distribution of donor-to-recipient TLC according to diagnosis. A, Donor-to-recipient pTLCRatio. B, Donor-to-recipient aTLCRatio. IPF, Idiopathic pulmonary fibrosis; pTLCRatio, donor-to-reci

Cumulative distribution of donor-to-recipient TLC according to diagnosis. A, Donor-to-recipient pTLC_Ratio. B, Donor-to-recipient aTLC_Ratio. IPF, Idiopathic pulmonary fibrosis; pTLC_Ratio, donor-to-recipient predicted total lung capacity ratio; aTLC_Ratio, donor-to-recipient actual total lung capacity ratio.
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Overall unadjusted survival by terciles of donor-to-recipient pTLCRatio. Symbols represent deaths. Vertical bars represent 68% confidence limits equivalent to ± 1 standard error. Numbers in parenthese

Overall unadjusted survival by terciles of donor-to-recipient pTLC_Ratio. Symbols represent deaths. Vertical bars represent 68% confidence limits equivalent to ± 1 standard error. Numbers in parentheses represent patients remaining at risk (P [log-rank] = .4). o = patients with largest 15% of pTLC_Ratio. • = patients with the middle 70% of pTLC_Ratio. □ = patients with the smallest 15% of pTLC_Ratio.
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Unadjusted survival in patients with emphysema stratified by donor-to-recipient aTLCRatio. o = patients with extreme values of aTLCRatio (n = 44). □ = the 70% of patients with more typical values (n =

Unadjusted survival in patients with emphysema stratified by donor-to-recipient aTLC_Ratio. o = patients with extreme values of aTLC_Ratio (n = 44). □ = the 70% of patients with more typical values (n = 108). Format is as in Figure 3. P (Wilcoxon) = .01.
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Predicted mean FEV1% after lung transplantation for emphysema from multivariable model of Table 4. A, Individual curves represent specific values of donor-to-recipient pTLCRatio. B, Individual curves

Predicted mean FEV1% after lung transplantation for emphysema from multivariable model of Table 4. A, Individual curves represent specific values of donor-to-recipient pTLC_Ratio. B, Individual curves represent specific values of donor-to-recipient aTLC_Ratio. FEV1%, Forced expiratory volume in 1 second; pTLC_Ratio, donor-to-recipient predicted total lung capacity ratio; aTLC_Ratio, donor-to-recipient actual total lung capacity ratio.
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Predicted mean FEV1% after lung transplantation for IPF from multivariable model of Table 4. A, Individual curves represent specific values of donor-to-recipient pTLCRatio. B, Individual curves repres

Predicted mean FEV1% after lung transplantation for IPF from multivariable model of Table 4. A, Individual curves represent specific values of donor-to-recipient pTLC_Ratio. B, Individual curves represent specific values of donor-to-recipient aTLC_Ratio. FEV1%, Forced expiratory volume in 1 second; pTLC_Ratio, donor-to-recipient predicted total lung capacity ratio; aTLC_Ratio, donor-to-recipient actual total lung capacity ratio.
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Predicted mean FEV1% after lung transplantation for bronchiectasis from multivariable model of Table 4. A, Individual curves represent specific values of donor-to-recipient pTLCRatio. B, Individual cu

Predicted mean FEV1% after lung transplantation for bronchiectasis from multivariable model of Table 4. A, Individual curves represent specific values of donor-to-recipient pTLC_Ratio. B, Individual curves represent specific values of donor-to-recipient aTLC_Ratio. FEV1%, Forced expiratory volume in 1 second; pTLC_Ratio, donor-to-recipient predicted total lung capacity ratio; aTLC_Ratio, donor-to-recipient actual total lung capacity ratio.
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Number of patients with spirometry measurements available at and beyond various time points, and number of spirometry measurements available for analysis (black bars, spirometry measurements; grey bar

Number of patients with spirometry measurements available at and beyond various time points, and number of spirometry measurements available for analysis (black bars, spirometry measurements; grey bars, patients).
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