The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 6 , Pages 1436-1442.e2 , June 2009

Impact of preconditioning protocol on anesthetic-induced cardioprotection in patients having coronary artery bypass surgery

  • Jan Fräßdorf, MD

      Affiliations

    • Department of Anesthesiology, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
    • Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, Germany
    • ,
  • Andreas Borowski, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, University Hospital Duesseldorf, Duesseldorf, Germany
    • ,
  • Dirk Ebel, MD

      Affiliations

    • Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, Germany
    • Department of Anesthesiology, Slingeland Ziekenhuis, Doetinchem, The Netherlands
    • ,
  • Peter Feindt, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, University Hospital Duesseldorf, Duesseldorf, Germany
    • ,
  • Manuel Hermes, MD

      Affiliations

    • Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, Germany
    • ,
  • Thomas Meemann, MD

      Affiliations

    • Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, Germany
    • ,
  • René Weber, MD

      Affiliations

    • Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, Germany
    • ,
  • Jost Müllenheim, MD, DEAA

      Affiliations

    • Department of Anesthesiology, South Tyneside District Hospital, South Shields, United Kingdom
    • ,
  • Nina C. Weber, PhD

      Affiliations

    • Department of Anesthesiology, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Benedikt Preckel, MD, MA, DEAA

      Affiliations

    • Department of Anesthesiology, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
    • Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, Germany
    • Corresponding Author InformationAddress for reprints: Benedikt Preckel, MD, MA, DEAA, Academic Medical Center, University of Amsterdam, Postbus 22660 H1Z-120, 1100 DD Amsterdam, The Netherlands.
    • ,
  • Wolfgang Schlack, MD, DEAA

      Affiliations

    • Department of Anesthesiology, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands

Received 30 January 2008 ,Accepted 6 April 2008.

  • Image Result

    Experimental protocol; T0 to T17 time points of measurements (hemodynamic and/or laboratory samples). AOX, Aortic crossclamping (= myocardial ischemia); CPB, cardiopulmonary bypass; TCI, target-contro

    Experimental protocol; T0 to T17 time points of measurements (hemodynamic and/or laboratory samples). AOX, Aortic crossclamping (= myocardial ischemia); CPB, cardiopulmonary bypass; TCI, target-controlled infusion of propofol; MAC, minimum alveolar concentration; OP, operative; ICU, intensive care unit. Sevo I group received 1 minimum alveolar concentration of sevoflurane for 5 minutes before cardiopulmonary bypass; Sevo II group received (2 times) 5 minutes of sevoflurane, interspersed by 5-minute washout 10 minutes prior to extracorporeal circulation.

  • Image Result
    Plasma concentrations of troponin I during the observation period of the study. The horizontal line marks the level of positive values for troponin I representing myocardial infarction. SEVO-I group r

    Plasma concentrations of troponin I during the observation period of the study. The horizontal line marks the level of positive values for troponin I representing myocardial infarction. SEVO-I group received 1 minimum alveolar concentration of sevoflurane for 5 minutes before CPB; SEVO-II group received (2 times) 5 minutes of sevoflurane, interspersed by 5-minute washout 10 minutes prior to extracorporeal circulation and CPB. Control patients were not treated with sevoflurane. Data are mean ± standard deviation. †††P < .001 versus baseline (control and SEVO-I group), †P < .05 versus baseline (SEVO-II group); ∗P < .05, ∗∗∗P < .001 control and SEVO-I group versus SEVO-II group at corresponding time points. CPB, Cardiopulmary bypass.

 Part of the work has been presented at the ASA meeting 2005, Atlanta, and at the ASA annual meeting 2004, Las Vegas.

 Support was provided from Deutsche Forschungsgemeinschaft (Bonn, Germany, grant No. SCHL 448/5-1), Siemens Medical Solutions Diagnostics (Fernwald, Germany), Abbott GmbH (Wiesbaden, Germany), and institutional resources.

PII: S0022-5223(08)01740-6

doi: 10.1016/j.jtcvs.2008.04.034

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 6 , Pages 1436-1442.e2 , June 2009

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