The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5 , Pages 1190-1194 , May 2009

Stability of an autologous platelet clot in the pericardial sac: An experimental and clinical study

  • Leonard M. Rademakers, MD

      Affiliations

    • Cardiovascular Research Institute Maastricht (CARIM), Department of Cardiothoracic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    • Corresponding Author InformationAddress for reprints: Leonard M. Rademakers, MD, Maastricht University Medical Center, Department of Cardiothoracic Surgery, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands.
    • ,
  • Paul F. Gründeman, MD, PhD

      Affiliations

    • Laboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Robert W. Bolderman, MD

      Affiliations

    • Cardiovascular Research Institute Maastricht (CARIM), Department of Cardiothoracic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    • ,
  • Frederik H. van der Veen, PhD

      Affiliations

    • Cardiovascular Research Institute Maastricht (CARIM), Department of Cardiothoracic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    • ,
  • Jos G. Maessen, MD, PhD

      Affiliations

    • Cardiovascular Research Institute Maastricht (CARIM), Department of Cardiothoracic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands

Received 18 July 2008 ,Revised 15 September 2008 ,Accepted 9 October 2008.

  • Image Result

    In vivo incubation of autologous platelet clot. Freshly manufactured autologous platelet gel clot in plastic test container just before administration to the pericardial sac.

    In vivo incubation of autologous platelet clot. Freshly manufactured autologous platelet gel clot in plastic test container just before administration to the pericardial sac.

  • Image Result

    In vitro incubation of autologous platelet clots. After 60 minutes of incubation at 37°C, the PRF clot remained solid while either APG clot formula liquefied almost completely. APG, Autologous platele

    In vitro incubation of autologous platelet clots. After 60 minutes of incubation at 37°C, the PRF clot remained solid while either APG clot formula liquefied almost completely. APG, Autologous platelet gel; APG-TXA, APG plus tranexamic acid; APG-AP, APG plus aprotinin; PRF, platelet-rich fibrin.

PII: S0022-5223(08)01692-9

doi: 10.1016/j.jtcvs.2008.10.012

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 5 , Pages 1190-1194 , May 2009

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