The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 4 , Pages 853-861 , April 2009

Reduction of four-and-a-half LIM-protein 2 expression occurs in human left ventricular failure and leads to altered localization and reduced activity of metabolic enzymes

  • Esta Bovill, MRCS

      Affiliations

    • Department of Medicine, University College London, London, United Kingdom
    • Corresponding Author InformationAddress for reprints: Esta Bovill, MRCS, c/o Oxford Heart Centre, John Radcliffe Hospital Headley Way, Headington, Oxford OX3 9DU, United Kingdom.
    • ,
  • Steven Westaby, FRCS, PhD

      Affiliations

    • Oxford Heart Center, John Radcliffe Hospital, Oxford, United Kingdom
    • ,
  • Alastair Crisp, MA

      Affiliations

    • Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    • ,
  • Shiney Jacobs, PhD

      Affiliations

    • Department of Medicine, University College London, London, United Kingdom
    • ,
  • Tony Shaw, PhD

      Affiliations

    • Department of Medicine, University College London, London, United Kingdom

Received 14 April 2008 ,Revised 13 August 2008 ,Accepted 1 September 2008.

References 

  1. Tarantini G, Buja P, Scognamiglio R, Razzolini R, Gerosa G, Isabella G, et al. Aortic valve replacement in severe aortic stenosis with left ventricular dysfunction: determinants of cardiac mortality and ventricular function recovery. Eur J Cardiothorac Surg. 2003;24:879–885
  2. Arimura T, Hayashi T, Matsumoto Y, Shibata H, Hiroi S, Nakamura T, et al. Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy. Biochem Biophys Res Commun. 2007;357:162–167
  3. Matsumoto Y, Hayashi T, Inagaki N, Takahashi M, Hiroi S, Nakamura T, et al. Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy. J Muscle Res Cell Motil. 2005;26:367–374
  4. Lange S, Auerbach D, McLoughlin P, Perriard E, Schafer BW, Perriard JC, et al. Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. J Cell Sci. 2002;115:4925–4936
  5. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the “phosphocreatine circuit” for cellular energy homeostasis. Biochem J. 1992;281:21–40
  6. Dzeja PP, Redfield MM, Burnett JC, Terzic A. Failing energetics in failing hearts. Curr Cardiol Rep. 2000;2:212–217
  7. O'Brien PJ, Gwathmey JK. Myocardial Ca(2+)- and ATP-cycling imbalances in end-stage dilated and ischemic cardiomyopathies. Cardiovasc Res. 1995;30:394–404
  8. Saupe KW, Spindler M, Tian R, Ingwall JS. Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase. Circ Res. 1998;82:898–907
  9. Depre C, Rider MH, Hue L. Mechanisms of control of heart glycolysis. Eur J Biochem. 1998;258:277–290
  10. Muller JM, Isele U, Metzger E, Rempel A, Moser M, Pscherer A, et al. FHL2, a novel tissue-specific coactivator of the androgen receptor. EMBO J. 2000;19:359–369
  11. Van Schaftingen E, Lederer B, Bartrons R. Hers HG A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. Eur J Biochem. 1982;129:191–195
  12. Bishop C, Chu TM, Shihabi ZK. Single stable reagent for creatine kinase assay. Clin Chem. 1971;17:548–550
  13. Chu PH, Ruiz-Lozano P, Zhou Q, Cai C, Chen J. Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system. Mech Dev. 2000;95:259–265
  14. Arber S, Hunter JJ, Ross JJ, Hongo M, Sansig G, Borg J, et al. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 1997;88:393–403
  15. Pashmforoush M, Pomies P, Peterson KL, Kubalak S, Ross JJ, Hefti A, et al. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med. 2001;7:591–597
  16. Radke MH, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, et al. Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proc Natl Acad Sci U S A. 2007;104:3444–3449
  17. Kong Y, Shelton JM, Rothermel B, Li X, Richardson JA, Bassel-Duby R, et al. Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. Circulation. 2001;103:2731–2738
  18. Purcell NH, Darwis D, Bueno OF, Muller JM, Schule R, Molkentin JD. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Mol Cell Biol. 2004;24:1081–1095
  19. McLoughlin P, Ehler E, Carlile G, Licht JD, Schafer BW. The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein. J Biol Chem. 2002;277:37045–37053
  20. Wojtas K, Slepecky N, von Kalm L, Sullivan D. Flight muscle function in Drosophila requires colocalization of glycolytic enzymes. Mol Biol Cell. 1997;8:1665–1675
  21. Saks VA, Tiivel T, Kay L, Novel-Chate V, Daneshrad Z, Rossi A, et al. On the regulation of cellular energetics in health and disease. Mol Cell Biochem. 1996;160-161:195–208
  22. Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, et al. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. J Biol Chem. 2000;275:33669–33678
  23. Kupershmidt S, Yang IC, Sutherland M, Wells KS, Yang T, Yang P, et al. Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system. Cardiovasc Res. 2002;56:93–103
  24. Nagueh SF, Shah G, Wu Y, Torre-Amione G, King NM, Lahmers S, et al. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation. 2004;110:155–162
  25. Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, et al. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res. 2004;95:708–716
  26. Filipeanu CM, Zhou F, Claycomb WC, Wu G. Regulation of the cell surface expression and function of angiotensin II type 1 receptor by Rab1-mediated endoplasmic reticulum-to-Golgi transport in cardiac myocytes. J Biol Chem. 2004;279:41077–41084
  27. Vertessy BG, Orosz F, Kovacs J, Ovadi J. Alternative binding of two sequential glycolytic enzymes to microtubules. Molecular studies in the phosphofructokinase/aldolase/microtubule system. J Biol Chem. 1997;272:25542–25546
  28. Parra J, Pette D. Effects of low-frequency stimulation on soluble and structure-bound activities of hexokinase and phosphofructokinase in rat fast-twitch muscle. Biochim Biophys Acta. 1995;1251:154–160
  29. Srere PA, Knull HR. Location-location-location. Trends Biochem Sci. 1998;23:319–320
  30. Donker DW, Maessen JG, Verheyen F, Ramaekers FC, Spatjens RL, Kuijpers H, et al. Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium. Am J Physiol Heart Circ Physiol. 2007;292:H2324–H2332

 Drs E. Bovill, S. Jacobs, and T. Shaw are supported by grants from the British Heart Foundation.

PII: S0022-5223(08)01508-0

doi: 10.1016/j.jtcvs.2008.09.006

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 4 , Pages 853-861 , April 2009

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