The Journal of Thoracic and Cardiovascular Surgery
Volume 136, Issue 5 , Pages 1131-1135 , November 2008

The legacy of coronary sinus interventions: Endogenous cardioprotection and regeneration beyond stem cell research

  • Werner Mohl, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    • Corresponding Author InformationAddress for reprints: Werner Mohl, MD, PhD, Department of Cardiothoracic Surgery, University of Vienna, Waehringerguertel 18-20, 1090 Vienna, Austria.
    • ,
  • Stefan Mina, BME

      Affiliations

    • Department of Biomedical Engineering, Austrian Research Centers, Wiener Neustadt, Austria
    • ,
  • Dejan Milasinovic

      Affiliations

    • Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    • ,
  • Hirofumi Kasahara, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    • ,
  • Sheng Wei, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria

Received 3 March 2008 ,Revised 18 April 2008 ,Accepted 15 May 2008.

References 

  1. Miura T, Hiramatsu T, Forbess JM, Mayer JE. Effects of elevated coronary sinus pressure on coronary blood flow and left ventricular function: implications after the Fontan operation. Circulation. 1995;92:298–303
  2. Beck CS, Stanton E, Batiuchok W, Leiter E. Revascularization of heart by graft of systemic artery into coronary sinus. JAMA. 1946;137:436–445
  3. Mohl W. The momentum of coronary sinus interventions clinically. Circulation. 1988;77:6–12
  4. Paz , et al. Coronary sinus reducer stent. J Thorac Cardiovasc Surg. 2008;136:1390
  5. Weigel G, Kajgana I, Bergmeister H, Riedl G, Glogar HD, Gyöngyösi M, et al. Beck and back: a paradigm change in coronary sinus interventions—pulsatile stretch on intact coronary venous endothelium. J Thorac Cardiovasc Surg. 2007;133:1581–1587
  6. Kar S, Drury JK, Hajduczki I, Eigler N, Wakida Y, Litvack F, et al. (1991) Synchronized coronary venous retroperfusion for support and salvage of ischemic myocardium during elective and failed angioplasty. J Am Coll Cardiol. 1991;18:271–282
  7. Mohl W, Simon P, Neumann F, Schreiner W, Punzengruber C. Clinical evaluation of pressure-controlled intermittent coronary sinus occlusion: randomized trial during coronary artery surgery. Ann Thorac Surg. 1988;46:192–201
  8. Syeda B, Schukro C, Heinze G, Modaressi K, Glogar D, Maurer G, et al. The salvage potential of coronary sinus interventions: meta-analysis and pathophysiologic consequences. J Thorac Cardiovasc Surg. 2004;127:1703–1712
  9. Mohl W, Kajgana I, Bergmeister H, Rattay F. Intermittent pressure elevation of the coronary venous system as a method to protect ischemic myocardium. 10.1510/icvts.2004.095364. Interact Cardiovasc Thorac Surg. 2005;4:66–69
  10. Mohl W, Komamura K, Kasahara H, Heinze G, Glogar D, Hirayama A, et al. Myocardial protection via the coronary sinus: long term effects of intermittent coronary sinus occlusion as adjunct to reperfusion in acute myocardial infarction. Circ J. 2008;72:526–533
  11. Mohl W. Embryonic recall: myocardial regeneration beyond stem cell transplantation. Wien Klin Wochenschr. 2007;119:333–336
  12. Zheng W, Seftor EA, Meininger CJ, Hendrix MJ, Tomanek RJ. Mechanisms of coronary angiogenesis in response to stretch: role of VEGF and TGF-beta. Am J Physiol Heart Circ Physiol. 2001;280:H909–H917
  13. Groenendijk BCW, Hierck BP, Vrolijk J, Baiker M, Pourquie MJBM, Gittenberger-de Groot AV, et al. Changes in shear stress–related gene expression after experimentally altered venous return in the chicken embryo. Circ Res. 2005;96:1291–1298
  14. Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Jung S, et al. VEGF- induced adult neovascularization: recruitment, retention and role of accessory cells. Cell. 2006;124:175–189
  15. Lazar HL, Yang XM, Rivers S, Treanor P, Bernard S, Shemin RJ. Retroperfusion and balloon support to improve coronary revascularization. J Cardiovasc Surg. 1992;33:538–544

PII: S0022-5223(08)01081-7

doi: 10.1016/j.jtcvs.2008.05.034

The Journal of Thoracic and Cardiovascular Surgery
Volume 136, Issue 5 , Pages 1131-1135 , November 2008

Article Tools

* Image Usage & Resolution