Bovine pericardial versus porcine stented replacement aortic valves: Early results of a randomized comparison of the Perimount and the Mosaic valves

Objective

A stented bovine pericardial valve might be less obstructive than a stented porcine valve. This study compared early hemodynamic function in a prospective series of 99 patients randomized to receive either a Mosaic or Perimount replacement aortic valve.

Methods

Echocardiography was performed early after surgery and at 1 year after surgery. Patients also filled in psychologic questionnaires and underwent a 6-minute walk.

Results

The groups were matched demographically. The Perimount valve was significantly less obstructive in terms of mean pressure difference (11 ± 5 vs 17 ± 7 mm Hg; P < .0001), with a trend in favor of a larger effective orifice area (1.47 ± 0.45 vs 1.28 ± 0.46 cm²; P = .05) postoperatively. There were no differences in left ventricular mass regression, aortic regurgitation, 6-minute walk, psychologic questionnaires, or mortality and clinical events.

Conclusion

The stented bovine pericardial valve was less obstructive than the stented porcine valve. Both valves were associated with similar and significant improvements in quality of life, exercise ability, and regression of left ventricular mass.

Abbreviations and Acronyms: LV, left ventricular, NS, no significant difference, NYHA, New York Heart Association, SD, standard deviation, SF-36, Short Form-36 health questionnaire

CTSNet classification: 35