The Journal of Thoracic and Cardiovascular Surgery
Volume 136, Issue 4 , Pages 843-849 , October 2008

Autologous fibrin sealant reduces the incidence of prolonged air leak and duration of chest tube drainage after lung volume reduction surgery: A prospective randomized blinded study

  • C. Moser, MD

      Affiliations

    • Division of Thoracic Surgery, University Hospital Zürich, Zurich, Switzerland
    • ,
  • I. Opitz, MD

      Affiliations

    • Division of Thoracic Surgery, University Hospital Zürich, Zurich, Switzerland
    • ,
  • W. Zhai, MD

      Affiliations

    • Division of Thoracic Surgery, University Hospital Zürich, Zurich, Switzerland
    • ,
  • V. Rousson, MD

      Affiliations

    • Department of Biostatistics, University Hospital Zürich, Zurich, Switzerland
    • ,
  • E.W. Russi, MD

      Affiliations

    • Division of Pneumology, University Hospital Zürich, Zurich, Switzerland
    • ,
  • W. Weder, MD

      Affiliations

    • Division of Thoracic Surgery, University Hospital Zürich, Zurich, Switzerland
    • ,
  • D. Lardinois, MD

      Affiliations

    • Division of Thoracic Surgery, University Hospital Zürich, Zurich, Switzerland
    • Corresponding Author InformationAddress for reprints: D. Lardinois, MD, Division of Thoracic Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.

Received 3 August 2007 ,Revised 19 December 2007 ,Accepted 12 February 2008.

References 

  1. Wain JC, Kaiser LR, Johnstone DW, Yang SC, Wright CD, Friedberg JS, et al. Trial of a novel synthetic sealant in preventing air leaks after lobectomy. Ann Thorac Surg. 2001;71:1623–1629
  2. Porte HL, Jany T, Akkad R, Conti M, Gillet PA, Guidat A, et al. Randomized controlled trial of a synthetic sealant for preventing alveolar air leaks after lobectomy. Ann Thorac Surg. 2001;71:1618–1622
  3. Lang G, Stamatis G, Lampl L, Hagman L, Mihai MG, Müller MR, et al. Efficacy and safety of topical application of human fibrinogen/thrombin-coated collagen patch (TachoComb) for treatment of air leakage after standard lobectomy. Eur J Cardiothorac Surg. 2004;25:160–166
  4. Gagarine A, Urschel JD, Miller JD, Bennett WF, Young JE. Effect of fibrin glue on air leak and length of hospital stay after pulmonary lobectomy. J Cardiovasc Surg (Torino). 2003;44:771–773
  5. Fabian T, Federico JA, Ponn RB. Fibrin glue in pulmonary resection: a prospective randomized blinded study. Ann Thorac Surg. 2003;75:1587–1592
  6. DeCamp MM, Blackstone EH, Naunheim KS, Krasna MJ, Wood DE, Meli YM, et al. Patient and surgical factors influencing air leak after lung volume reduction surgery: lessons learned from the National Emphysema Treatment Trial. Ann Thorac Surg. 2006;82:197–207
  7. Fishman A, Martinez F, Naunheim K, Piantadosi S, Wise R, Ries A, et al. National Emphysema Treatment Trial Research Group. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med. 2003;348:2059–2073
  8. Naunheim KS, Wood DE, Mohsenifar Z, Sternberg AL, Criner GJ, DeCamp MM, et al. Long-term follow-up of patients receiving lung-volume-reduction surgery versus medical therapy for severe emphysema by the National Emphysema Treatment Trial Research Group. Ann Thorac Surg. 2006;82:431–443
  9. Bloch KE, Georgescu CL, Russi EW, Weder W. Gain and subsequent loss of lung function after lung volume reduction surgery in case of severe emphysema with different morphologic patterns. J Thorac Cardiovasc Surg. 2002;123:845–854
  10. Geddes D, Davies M, Koyama H, Hansell D, Pastorino U, Pepper J, et al. Effect of lung-volume-reduction surgery in patients with severe emphysema. N Engl J Med. 2000;343:239–245
  11. Cooper JD, Patterson GA, Sundaresan RS, Trulock EP, Yusen RD, Pohl MS, et al. Results of 150 consecutive bilateral lung volume reduction procedures in patients with severe emphysema. J Thorac Cardiovasc Surg. 1996;112:1319–1330
  12. Tutic M, Bloch KE, Lardinois D, Brack T, Russi EW, Weder W. Long-term results after lung volume reduction surgery in patients with α1-antitrypsin deficiency. J Thorac Cardiovasc Surg. 2004;128:408–413
  13. McKenna RJ. Complications after lung volume reduction surgery. Chest Surg Clin N Am. 2003;13:701–709
  14. Fleisher AG, Evans KG, Nelems B, Finley RJ. Effect of routine fibrin glue use on the duration of air leaks after lobectomy. Ann Thorac Surg. 1990;49:133–134
  15. Wong K, Goldstraw P. Effect of fibrin glue in the reduction of post-thoracotomy alveolar air leak. Ann Thorac Surg. 1997;64:979–981
  16. Macchiarini P, Wain J, Almy S, Dartevelle P. Experimental and clinical evaluation of a new synthetic, absorbable sealant to reduce air leaks in thoracic operations. J Thorac Cardiovasc Surg. 1999;117:751–758
  17. Allen MS, Wood DE, Hawkinson RW, Harpole DH, McKenna RJ, Walsh GL, et al. 3M Surgical Sealant Study Group. Prospective randomized study evaluating a biodegradable polymeric sealant for sealing intraoperative air leaks that occur during pulmonary resection. Ann Thorac Surg. 2004;77:1792–1801
  18. Belboul A, Dernevik L, Aljassim O, Skrbic B, Rådberg G, Roberts D. The effect of autologous fibrin sealant (Vivostat) on morbidity after pulmonary lobectomy: a prospective randomised, blinded study. Eur J Cardiothoracic Surg. 2004;26:1187–1191
  19. Henrik K, Kjaergard HK, Horace R, Trumbull MD. Vivostat system autologous fibrin sealant: preliminary study in elective coronary bypass grafting. Ann Thorac Surg. 1998;66:482–486
  20. Hanks JB, Kjaergard HK, Hollingsbee DA. A comparison of the haemostatic effect of Vivostat patient-derived fibrin sealant with oxidised cellulose (Surgicel) in multiple surgical procedures. Eur Surg Res. 2003;35:439–444
  21. Kjaergard HK, Pedersen JH, Krasnik M, Weis-Fogh US, Fleron H, Griffin HE. Prevention of air leakage by spraying Vivostat fibrin sealant after lung resection in pigs. Chest. 2000;117:1124–1127
  22. Anegg U, Lindenmann J, Matzi V, Smolle J, Maier A, Smolle-Jüttner F. Efficiency of fleece-bound sealing (TachoSil) on air leaks in lung surgery: a prospective randomized trial. Eur J Cardiothorac Surg. 2007;31:198–202
  23. Hazelrigg SR, Boley TM, Naunheim KS, Magee MJ, Lawyer C, Henkle JQ, et al. Effect of bovine pericardial strips on air leak after stapled pulmonary resections. Ann Thorac Surg. 1997;63:1573–1575
  24. Stammberger U, Klepetko W, Stamatis G, Hamacher J, Schmid RA, Wisser W, et al. Buttressing the staple line in lung volume reduction surgery: a randomized three-center study. Ann Thorac Surg. 2000;70:1820–1825
  25. Cerfolio RJ, Bass CS, Pask AH, Katholi CR. Predictors and treatment of persistent air leaks. Ann Thorac Surg. 2002;73:1727–1730
  26. Varela G, Jiménez MF, Novoa N, Aranda JL. Estimating hospital cost attributable to prolonged air leak in pulmonary lobectomy. Eur J Cardiothorac Surg. 2005;27:329–333
  27. Imfeld S, Bloch KE, Weder W, Russi EW. The BODE index after lung volume reduction surgery correlates with survival. Chest. 2006;129:873–878

PII: S0022-5223(08)01031-3

doi: 10.1016/j.jtcvs.2008.02.079

The Journal of Thoracic and Cardiovascular Surgery
Volume 136, Issue 4 , Pages 843-849 , October 2008

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