The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 3 , Pages 781-783 , March 2009

The particle gel immunoassay as a rapid test to rule out heparin-induced thrombocytopenia?

  • Katharina Schallmoser, MD

      Affiliations

    • University Clinic of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
    • ,
  • Camilla Drexler, MD

      Affiliations

    • University Clinic of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
    • ,
  • Eva Rohde, MD

      Affiliations

    • University Clinic of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
    • ,
  • Dirk Strunk, MD

      Affiliations

    • Department of Hematology and Stem Cell Transplantation, University Clinic of Internal Medicine, Medical University of Graz, Graz, Austria
    • ,
  • Andrea Groselj-Strele, MSc

      Affiliations

    • Office for Biostatistics, Center for Medical Research, Medical University of Graz, Graz, Austria
    • ,
  • Gerhard Lanzer, MD

      Affiliations

    • University Clinic of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
    • ,
  • Hartmut Kroll, MD

      Affiliations

    • Institute for Transfusion Medicine Dessau, Red Cross Blood Transfusion Service NSTOB, Dessau, Germany
    • ,
  • Simon Panzer, MD

      Affiliations

    • Clinical Department of Blood Group Serology, Medical University of Vienna, Vienna, Austria
    • Corresponding Author InformationAddress for reprints: Simon Panzer, MD, Clinical Department of Blood Group Serology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

Received 27 November 2007 ,Accepted 18 March 2008.

References 

  1. Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost. 2006;4:759–765
  2. Selleng K, Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia in intensive care patients. Crit Care Med. 2007;35:1165–1176
  3. Zwicker JI, Uhl L, Huang WY, Shaz BH, Bauer KA. Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2004;2:2133–2137
  4. Pouplard C, Gueret P, Fouassier M, Ternisien C, Trossaert M, Régina S, et al. Prospective evaluation of the ‘4Ts’ score and particle gel immunoassay specific to heparin/PF4 for the diagnosis of heparin-induced thrombocytopenia. J Thromb Haemost. 2007;5:1373–1379
  5. Eichler P, Budde U, Haas S, Kroll H, Loreth RM, Meyer O, et al. First workshop for detection of heparin-induced antibodies: validation of the heparin-induced platelet-activation test (HIPA) in comparison with a PF4/heparin ELISA. Thromb Haemost. 1999;81:625–629

PII: S0022-5223(08)00659-4

doi: 10.1016/j.jtcvs.2008.03.044

The Journal of Thoracic and Cardiovascular Surgery
Volume 137, Issue 3 , Pages 781-783 , March 2009

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