The Journal of Thoracic and Cardiovascular Surgery
Volume 136, Issue 1 , Pages 220-221 , July 2008

Fatal thrombotic event after infusion of recombinant activated factor VII after cardiac surgery

  • N. Pichon, MD

      Affiliations

    • Medical-Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France
    • Centre de Recherche Clinique, Dupuytren Teaching Hospital, Limoges, France
    • Corresponding Author InformationAddress for reprints: Nicolas Pichon, MD, Intensive Care Unit, CHU Dupuytren, 2 avenue Martin Luther King, 87042 Limognes, France.
    • ,
  • F. Bellec, MD

      Affiliations

    • Medical-Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France
    • ,
  • S. Sekkal, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Dupuytren Teaching Hospital, Limoges, France
    • ,
  • J.P. Marsaud, MD

      Affiliations

    • Department of Anesthesiology, Dupuytren Teaching Hospital, Limoges, France
    • University of Limoges, Limoges, France
    • ,
  • M. Laskar, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, Dupuytren Teaching Hospital, Limoges, France
    • University of Limoges, Limoges, France
    • ,
  • B. François, MD

      Affiliations

    • Medical-Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France
    • Centre de Recherche Clinique, Dupuytren Teaching Hospital, Limoges, France
    • ,
  • P. Vignon, MD, PhD

      Affiliations

    • Medical-Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France
    • Centre de Recherche Clinique, Dupuytren Teaching Hospital, Limoges, France
    • University of Limoges, Limoges, France

Received 24 August 2007 ,Revised 12 September 2007 ,Accepted 19 October 2007.

References 

  1. Warren O, Mandal K, Hadjianastassiou V, Knowlton L, Panesar S, John K, et al. Recombinant activated factor VII in cardiac surgery: a systematic review. Ann Thorac Surg. 2007;83:707–714
  2. DiDomenico RJ, Massad MG, Kpodonu J, Navarro RA, Geha AS. Use of recombinant activated factor VII for bleeding following operations requiring cardiopulmonary bypass. Chest. 2005;127:1828–1835
  3. O'Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006;295:293–298
  4. Karkouti K, Beattie WS, Wijeysundera DN, Yau TM, McCluskey SA, Ghannam M, et al. Recombinant factor VIIa for intractable blood loss after cardiac surgery: a propensity score–matched case–control analysis. Transfusion. 2005;45:26–34
  5. VonHeymann C, Redlich U, Jain U, Kastrup M, Schroeder T, Sander M, et al. Recombinant activated factor VIIa for refractory bleeding after cardiac surgery: a retrospective analysis of safety and efficacy. Crit Care Med. 2005;33:2241–2246

PII: S0022-5223(08)00311-5

doi: 10.1016/j.jtcvs.2007.10.084

The Journal of Thoracic and Cardiovascular Surgery
Volume 136, Issue 1 , Pages 220-221 , July 2008

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